Last season, the New Orleans Saints accomplished something no team in NFL history previously achieved against Tom Brady. They beat him twice during the same regular season.

If they want to make it three in a row, it will be former Bucs QB Jameis Winston who must beat Brady. The latter threw for his NFL-record 600th TD past week.

The 6-1 Buccaneers are the 5-point road favorites over the 4-2 Saints in the NFL picks.

Check out the latest Buccaneers vs. Saints odds ahead of the matchup in Week 8.

Buccaneers vs. Saints Key Matchups

Tampa Bay Defense vs. Alvin Kamara: NFL betting sites wouldn’t have factored this one into their player props. Saints RB Kamara went over eight receptions and 100 receiving yards in the first half of Monday’s game. No NFL back had done that since 2004. No player in the league can beat an opponent in more ways than Kamara.

Brady vs. Saints Pass Defense: Buccaneers QB Brady has thrown for 4+ TDs in 37 career games, tied for the most in the NFL since 1950 with ex-Saints QB Drew Brees. New Orleans is second in the NFL with nine interceptions.

Brady vs Winston: It’s Brady against the guy he replaced as QB1 for the Buccaneers. Will Winston gain extra motivation from the chance to outplay the legend? Brady is 1-0 vs Winston. His Patriots beat Winston’s Bucs 19-14 in Week 5 of the 2017 season.

RELATED: NFL Week 8 Odds & Betting Lines For All Games

5 Key Buccaneers vs. Saints Key Stats

20: Carries by Kamara in Monday’s win over Seattle, his fourth 20+ carry game this season. He had one through his first 60 NFL games.

3: Number of Brady’s NFL-leading 21 TD passes that he’s thrown on the road this season.

5-3: Saints’ record as a home underdog since 2014, second-best in the NFL (62.5%).

9-2: Buccaneers’ record as an away favorite with Brady at QB.

10: TDs by RB Leonard Fournette in 20 games with Tampa Bay. He scored eight in his last two seasons for Jacksonville.

RELATED: NFL Week 8 Picks & Best Bets For Every Game

Buccaneers vs. Saints Player Props

Tom Brady under 2.5 passing TDs

Odds: -130 at Caesars Sportsbook

Only three of Brady’s NFL-leading 21 TD passes have come on the road.

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Alvin Kamara under 65.5 rushing yards

Odds: -110 at Caesars Sportsbook

In two games against the Bucs last season, Kamara ran for 16 and 40 yards.

Chris Godwin over 74.5 receiving yards

Odds: -115 at BetMGM

Godwin went for a season-high 111 yards last week.

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Buccaneers vs. Saints Key Moneyline

Tampa Bay is 6-1 this season. Add in the 2020 playoffs and they are 10-1 over the last 11 games. Go back into the 2020 regular season and the streak extends to 14-1. On the road, the Buccaneers are 11-2 in their past 13 games.

The Saints were upset 27-21 by the New York Giants in their only game so far this season played at the Caesars Superdome. Their Week 1 home victory over the Green Bay Packers was played at a neutral site in Jacksonville due to Hurricane Ida.

The Bucs look to be a solid play at betting apps with a moneyline of -240 at DraftKings. .

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Buccaneers vs. Saints Key Point Spread

Since Brady became Tampa Bay’s QB last season, no NFL team has covered the spread more often as the away team than the Buccaneers. They are 11-3 ATS on the road in NFL spreads and 9-2 ATS at sportsbooks as the road chalk.

On the other hand, the Bucs are 1-5 ATS in their last six visits to the Big Easy. New Orleans is 7-3 ATS in the last 10 games against an opponent from the NFC South. The Saints are also 5-3 ATS as a home underdog since 2014. That 62.5% success rate is No. 2 in the NFL over that span. Take the +5 at BetMGM (-110) and go with the Saints.

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Buccaneers vs. Saints Key Totals

Overall, neither of these teams are proving to be very good Over plays in total NFL betting this season. Tampa Bay is 4-3, while New Orleans is 2-4. Since Brady became their QB, the Buccaneers are just 11-9 on the Over/Under.

Interestingly, Tampa Bay went Uver in 12 of 16 games in 2019, the final season with Winston as the Bucs’ QB. The total has gone Under in six of the Saints’ last eight games and in seven of their last nine contests against NFC opposition.

Tampa Bay has gone Over in 11 of the past 13 games against NFC South teams. The Bucs are scoring 40.5 points per game at home and just 23.6 ppg on the road. Go with the Under 49.5 at FanDuel.

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