Both the Buffalo Bills and New York Jets are coming off embarrassing setbacks during Week 9 of the NFL season. That’s about par for the course in the case of the Jets. It was completely unexpected when the discussion turned to Buffalo’s 9-6 loss to the previously 1-6 Jacksonville Jaguars.

Oddsmakers are anticipating that reality will return to NFL betting during this Week 10 AFC East matchup. The division-leading Bills are set as 13-point favorites in the NFL picks.

Take a look at Bills vs. Jets odds, injury report, betting lines and more. And don't forget, for fans of sports betting in New York, the state continues to make progress towards eventual legalization, with the launch of online sportsbooks expected before Super Bowl LVI in Feb. 2022. Bookmark BetMGM bonus code New York to see offers when they are available.

Bills vs Jets Key Matchups

Buffalo’s lack of running game vs Jets’ lack of run defense: The Bills can’t run the ball. Take QB Josh Allen’s 39.9 yards per game out of the equation and Buffalo running backs are averaging 79.9 ypg on the ground. The Jets can’t stop the run (23rd, 133.25 ypg). Which liability will prove to be more of a crutch in this game?

Jets pass rush vs weakened Bills O line: Buffalo’s offensive line is crippled by injury. The Jaguars had seven sacks through seven games. They got to Allen four times and also registered 8 QB hits. The Jets have 18 sacks (T18) and 76 QB pressures (22nd).

Bills offense vs Jets defense: If there was a group to bounce back against following their worst offensive output of the season, Buffalo found it in the Jets. Their defense rates 32nd in the NFL in yards (408.1) and points (31.4) allowed per game, and in takeaways (five).

RELATED: NFL Week 10 Odds & Betting Lines For All Games

5 Key Bills vs Jets Stats

17: Number of games played since the previous time that Bills QB Allen had failed to produce a TD during a game.

30+: The Jets have scored over 30 points in two successive games. They’d failed to reach the 30-point barrier in their prior 27 games.

5: Number of passing TDs surrendered by the Bills this season, the NFL’s No. 1 pass defense. The Jets don’t know if rookie Zach Wilson or backup Mike White will be starting at QB.

486: Yards gained by the Jets in last week’s 45-30 loss to the Colts, the most in a setback since Week 17 of the 2000 season.

1-9: Buffalo’s record when Allen throws 2+ interceptions.

Bills vs Jets Weather Forecast

After spending last week stumbling around in the Florida sunshine, maybe some Northeast November weather is exactly what the Bills need to scrub away the stench. Except they aren’t really going to get it. Sunday’s forecast for MetLife Stadium is calling for clouds, 6 mph wind and a game-time temperature of 50 degrees.

Bills vs Jets Player Props

Bills QB Josh Allen over 6.5 rushing attempts

Odds: -120 at Caesars Sportsbook

In four full games against the Jets, Allen has never carried the ball fewer than nine times.

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Jets WR Jamison Crowder over 43.5 receiving yards

Odds: -115 at BetMGM

Crowder caught eight passes for 84 yards in Mike White’s previous full start at QB.

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Bills WR Stefon Diggs under 73.5 receiving yards

Odds: -115 at BetMGM

Diggs is averaging just 55.7 yards per game in his career against the Jets.

RELATED: NFL Week 10 Picks & Best Bets For Every Game

Bills vs Jets Moneyline

The Bills have won two straight and three of four from the Jets. Buffalo has won three in a row over the Jets on the road. Both of Buffalo’s losses have come on the road in the team’s past three games. The Bills are just 2-2 straight up away from home this season.

Last season, Buffalo rebounded from its worst stretch of the season – back-to-back losses to the Titans and Chiefs – with a victory at the Jets. Buffalo is also 4-0 in games following their four most recent regular season losses. Buffalo is the play here – but at the moneyline of -675 being offered at NFL betting apps, it isn’t worth the risk.

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Bills vs Jets Point Spread

After opening the season 4-1 against the spread, Buffalo is 0-2-1 in the NFL spreads over the past three games. Recent Jets-Bills games have been closely fought. The average margin of victory over the past five games is six points.

Over the past 12 games played during the month of November, Buffalo is 9-2-1 ATS. The Jets are 2-7 ATS over their last nine games. However, they are also 4-1 ATS in their past five home games. It’s wise to anticipate a bounce-back performance from the Bills. But NFL betting sites are giving them 13 points. That’s a lot of ground to cover. Take the Jets and the points at home. You can get the Jets +13 at DraftKings.

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Bills vs Jets Totals

In three of their last four meetings, the Jets have held the Bills to 18 points or less. They’ve kept Buffalo below 20 points in three of the last five games at MetLife Stadium. Buffalo is the No. 4 scoring offense in the NFL, averaging 29.4 points per game. The Jets are the No. 32 scoring defense in the league (31.4).

The total has gone over in each of the Jets’ last five games. The over has also proven to be the correct play in nine of Buffalo’s last 13 road games. The total is set at 47.5 by sportsbooks. Play the over. You can get Over 47.5 (-110) at FanDuel.

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