• Bookies
  • NFL
  • NFL Picks
  • Buffalo Bills vs LA Rams Picks, Point Spreads & Predictions For 2022 NFL Kickoff Game

Buffalo Bills vs LA Rams Picks, Point Spreads & Predictions For 2022 NFL Kickoff Game

Adam Thompson for Bookies.com

Adam Thompson  | 7 mins

Buffalo Bills vs LA Rams Picks, Point Spreads & Predictions For 2022 NFL Kickoff Game

Up to $1,250 on Caesars

Bet Now ➜

The 2022 NFL betting season is starting with a bang, as Matthew Stafford and the Los Angeles Rams begin the defense of their Super Bowl championship by hosting this year’s favorite, the Buffalo Bills. 

Josh Allen and the Bills led the league in scoring last year and are considered by many to be the top team in 2022, including at every online sportsbook where they’re at the top of NFL futures markets. The Rams may believe otherwise, and aim to prove it after their championship banner is unveiled. 

Bookies.com NFL handicapper Adam Thompson - who has hit on a whopping 62-64% of his NFL picks three years running - is back with his best NFL predictions for Rams vs. Bills at SoFi Stadium. 

Bills vs. Rams Point Spread Prediction

The Bills are laying 2.5 points on the road on betting sites against the defending Super Bowl champions. That says a lot about the expectations of Buffalo, which is the favorite in most Super Bowl odds markets. But perhaps the Rams are being a little undervalued here. They are, after all, No. 5 on Super Bowl futures tables, behind only the Bills, Buccaneers, Chiefs and Packers. 

This line was affected by reports of Matthew Stafford nursing a sore elbow, but there’s no indication it will impact his Week 1 availability or play. In fact, he says he's feeling 100%. The Rams have covered in every Week 1 game under coach Sean McVay and you know they’ll be amped for this one. L.A. fans should be too. 

Best Bet: Take the points with the host Rams for your Rams vs. Bills point spreads pick. They'll be fired up. 

RELATED: NFL Week 1 Odds, Moneylines and Point Spreads

 Bills vs. Rams Totals Prediction

The total on betting apps jumped from 52 points to 53 for the NFL Kickoff Game, then fell back down to 52. It's still one of the highest numbers of the opening week of the 2022 NFL season. Each team is known for its offense, especially the passing attack. Allen has Stefon Diggs, Stafford has Cooper Kupp. Combined, the Bills and Rams accounted for 53.5 ppg last season, ranking third and eighth in scoring, respectively. 

But they also accounted for only 38.9 ppg allowed. Buffalo ranked No. 1 in fewest points allowed in 2021, the Rams were middle-of-the-pack but allowed just 18.8 ppg in the playoffs. 

Neither defense should take a big step back. The Bills added Von Miller from the Rams, and used their first-rounder on CB Kaiir Elam, who should start right away. The Rams talked Aaron Donald back for another year and replaced Miller with Bobby Wagner. The defenses are scary good.

Best Bet: The top play is a Kickoff Game Under for Rams vs Bills picks.


Up to $1,250 on Caesars

Bet Now ➜

Bills vs. Rams Moneyline Prediction

Since 2003, a span of 19 years, the road team has won the NFL Kickoff Game just three times. History doesn’t mean much in general, and most of the home teams in the past were the favorites. 

This is a true marquee game between Super Bowl contenders. The Bills are the favorites and have something to prove. This primetime game is a celebration of the Rams’ accomplishments, and a loss puts a wet blanket on the entire night. Is either worth fading? 

Best Bet: There is more value on the host Rams at plus odds but neither side on the moneyline is overly appealing for your Rams vs. Bills picks. 


Bet $5, Win $150 in Bonus Bets If Your Bet Wins

Bet Now ➜

Bills vs. Rams Best Player Props

Josh Allen & Matthew Stafford – 2 Passing TDs Each

Odds: +157 at PointsBet

Both of these teams have questions to answer in the backfield, but each has elite QBs with elite targets in the pass attack. Each also has elite defensive backfields. In fact, the Bills and Rams ranked 1 and 2, respectively, in fewest pass TDs allowed in 2021. 

But Stafford and Allen were as consistent, in a good way, as they came last year. In the 21 Rams games including the playoffs through the Super Bowl, Stafford had at least two TDs 17 times. Allen had a similar trajectory, hitting the two-TD threshold 15 times in 19 contests. Parlay these two props together at PointsBet to grab +157 odds. 

Matthew Stafford, Over 268.5 Pass Yards

Odds: -103 at Caesars Sportsbook ➜

The Bills allowed the fewest pass yards of any team in 2021, though the armor started to rust later in the year, especially on the road. Its five highest pass yards allowed games were all away from home, including three of at least 296 yards, all three of which came in the second half of the season. 

Stafford finished over this total 10 times. He still has Cooper Kupp, the NFL’s top target, and now adds Allen Robinson II, who has to be salivating for this opportunity after eight seasons with the Jaguars and Bears (he had 150-plus targets in four of those years). Lock in the best odds for this prop at Caesars. 


Up to $1,250 on Caesars

Bet Now ➜

Darrell Henderson, Under 2.5 Receptions

Odds: -130 at BetMGM ➜

Henderson averaged 2.4 receptions per game for the Rams last year – and that was as the RB1 in the offense for many of the games he played. Cam Akers is back in the mix and both are expected to be used nearly equal, according to coach Sean McVay. 

It only makes sense that Henderson’s pass targets are likely to go down with Akers' return. And you can add to that Buffalo’s success in limiting backs out of the backfield. No team allowed fewer receptions to RBs than the Bills last year. Secure these odds over at BetMGM before the line moves. 


Get $200 in Bonus Bets when you Bet $10 on March Matchups

Bet Now ➜

About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been estabilshed as one of the nation's premier NFL and MLB handicappers, and his horse racing and PGA picks have produced major winners over the last 12 months.
trusted casinos
Our trusted sports betting partners bring you safe and fun playing experiences
Bookies.com only works with licensed, regulated sportsbooks. Learn more about our commitment to responsible gaming.