A Monday Night Football matchup that could alter the course of the NFC Playoffs is set for Week 14, as Kyler Murray and the Arizona Cardinals host Matthew Stafford and the Los Angeles Rams.

The Cardinals (10-2) own the best record in the NFC, while the Rams (8-4) aren’t far behind as both chase the same division title and at least one home game in the postseason. The Cardinals rolled the Rams 37-20 in L.A. earlier this season.

Betting sites and betting apps have Arizona as a slim three-point home favorite, with an Over/Under of 51.5 points in the latest Rams vs. Cardinals odds.

This is one of the NFL spreads that has moved since opening. The opening line had Arizona -2.5, and the total has dropped from 52.5.

Take a look at Cardinals vs. Rams odds, injury report, betting lines and more.

Rams vs. Cardinals Key Matchups

Matthew Stafford vs. Himself: The Rams are a perfect 5-0 when Stafford doesn’t throw an INT. In all victories, Stafford has tossed 23 TDs and three INTs. In losses, it’s a 7/6 split.

Tyler Higbee vs. Cardinals LBs: The Rams are 4-1 when their standout TE gains 40-plus receiving yards. Arizona allows 36 ypg to TEs, the sixth-fewest.

Cooper Kupp vs. Cardinals DBs: Kupp has at least 92 receiving yards in all but one game this season. That one game: Oct. 3 vs. the Cardinals, when he was held to a season-low five receptions for 64 yards.

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5 Key Rams vs. Cardinals Stats

.000: The Rams are 0-4 when they lose the turnover battle and 8-0 when they don’t. Arizona ranks fourth in the NFL in fewest turnovers and fifth in most turnovers caused.

5: Touchdowns allowed to running backs by the Arizona defense. Only the Patriots (4) have allowed fewer. Rams RBs have 11 TDs this season.

7: Touchdowns allowed to wide receivers by the Los Angeles defense. Only the Bills (3) and Chargers (6) have allowed fewer. Arizona WRs have 16 TDs in 12 games.

14: QB hits registered by Aaron Donald in L.A. wins this season, compared to three in team defeats. He didn’t register a hit or even a tackle in the Rams’ loss to the Cardinals in Week 4.

51.3: The receiving yards average for DeAndre Hopkins in three games vs. the Rams as a member of the Cardinals. Hopkins is only averaging 57.6 ypg this season, this after tallying 88 ypg last year.

Rams vs. Cardinals Weather Forecast

Monday night in Phoenix will be pleasant, with temperatures in the 50s after a high of 73 during the day. No rain is expected in the forecast – not a shocker – and none of it matters anyway with the domed conditions of State Farm Stadium.

Rams vs. Cardinals Player Props

Cooper Kupp, Over 90.5 Receiving Yards

Odds: -110 at FanDuel

Only once all season has Kupp finished with under 92 receiving yards. It was against these Cardinals and Arizona has a top-five pass defense, but we’ll back the trend that Kupp’s gained at least 95 yards in seven straight games. He’s recession-proof.

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Kyler Murray, Under 296.5 Total Yards

Odds: -115 at DraftKings

This seems like a doable number for the dual-threat Murray. But he’s hit this total just once in the last six games. That includes a solid effort in a 37-20 win vs. the Rams, but one that still came up short. He’s averaging only 203 ypg passing vs. L.A. in his career.

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Zach Ertz, Under 41.5 Receiving Yards

Odds: -115 at Caesars Sportsbook

Ertz has been statistically inconsistent in his six games with Arizona. Two weeks ago he had eight catches for 88 yards and two TDs, last week he had one catch for 10 yards. A fully healthy WR corps means fewer balls to go around.

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Rams vs. Cardinals Moneyline

The Cardinals are -150 favorites on the moneyline, meaning it would take a $150 wager to win $100 in profit. Conversely, underdog Los Angeles is +130 (a $100 bet means $130 in profit). A strong majority of moneyline picks at sportsbooks have sided with Arizona so far.

That’s because there is value in taking the best team in the NFL, at least from a record standpoint. The Cardinals are 8-1 when Kyler Murray plays, the lone defeat a last-second loss to the equally strong Packers. The Rams, for all their firepower and star power, have lost four straight against teams with winning records. There is some value in taking the home team here. You can get the Cardinals -150 at BetMGM.

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Rams vs. Cardinals Point Spread

The Cardinals are at -3, up from -2.5. The spread is set in that oddsmakers are giving them home-field advantage points but not much else. On paper, these teams are similar, but in any noticeable difference, the edge goes to Arizona. That especially includes stopping the pass, something the Cardinals are very good at (fourth-fewest pass yards allowed) and the Rams are very middle-of-the-pack (17th).

When Arizona wins, it’s been by a sizable margin. All but two of Arizona’s eight wins have been by double figures, and that includes a 37-20 victory at L.A. in Week 4. But we know what the Rams are capable of, and they got back on track with a 30-point win last week.

We think Arizona is going to win, but it’s going to be a close game. Those looking for Monday night NFL betting action should consider the moneyline over laying points. If you prefer the spread, find it at -2.5.

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Rams vs. Cardinals Totals

The Over/Under for Monday Night Football sits at 51.5; only the Bills-Buccaneers showdown has a higher total (52). It depends on whether you trust the offenses or the defenses to dictate the game. Combined these teams are averaging 56.6 ppg, though that number is only 47 the last three weeks. Conversely, the defenses are allowing just 41.2 ppg. That includes three Matthew Stafford pick-6s, too.

These teams totaled 57 points in their first meeting, but the defenses have hunkered down in the stretch run. The Over is 1-5 for Cardinals or Rams games when the total is over 50.5. The Under is worth adding to your NFL picks lineup for Week 14.

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