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Adam Thompson for Bookies.com

By Adam Thompson | | 8 mins

Los Angeles Rams at San Francisco 49ers Picks & MNF Betting Predictions

Los Angeles Rams at San Francisco 49ers Picks & MNF Betting Predictions

NFC West rivals with something to prove coming off losses face off on Monday Night Football, as Jimmy Garoppolo and the San Francisco 49ers host Matthew Stafford and the Los Angeles Rams. Each squad seeks a rebound after disappointing Week 9 conclusions; the Rams (7-2) lost 28-16 at home to the Derrick Henry-less Titans, while the Niners (3-5) were downed 31-17 at home by a Cardinals squad missing its top two players.

Betting sites and betting apps have Los Angeles as a four-point favorite, with an Over/Under of 49 points in the latest Rams vs. 49ers odds. This is one of the NFL spreads that has moved one point from an opening line of Rams -3.

Take a look at Rams vs. 49ers odds, injury report, betting lines and more.


Rams vs. 49ers Key Matchups

Leonard Floyd vs. Niners O-Line: Floyd has 7.5 sacks and the Rams rank No. 2 in sacks of opposing QBs. The Niners only allow two sacks per game but gave up five in their last game.

Elijah Mitchell vs. Rams Front 7: The 49ers rookie RB is averaging 6.1 yards per carry over the past four games, and 81 yards per game. The Rams defense ranks in the top 10 in both, including No. 1 in fewest yards allowed on the road.

Matthew Stafford vs. 49ers Pass D: Stafford’s 111 QB rating ranks at the top of the NFL among those who have started at least six games. The Niners’ QB rating allowed at home is a robust 116.1.


RELATED: NFL Week 10 Odds & Betting Lines For All Games


5 Key Rams vs. 49ers Stats

1: The NFL ranking among receivers for Cooper Kupp in receptions (74), yards (1,019) and TDs (10).

1.1: The pass TDs allowed per game by the Rams, as well as the average of TDs thrown per game by 49ers QB Jimmy Garoppolo.

3: The Rams have allowed three rushing TDs by QBs this season; only the Texans, Chiefs and 49ers have allowed more. Perhaps that opens the gameplan to allow Trey Lance the ball in the red zone.

38: The magic number for Matthew Stafford attempts and Rams success. L.A. is 1-2 when Stafford throws the ball 39 or more times, and 6-0 when he’s under that number.

75: Receptions allowed to tight ends by the Rams, second only to the Eagles in amount. George Kittle had six receptions for 101 yards and a TD last week, his first game since Week 4.


Rams vs. 49ers Weather Forecast

Monday night in San Francisco offers a consistent night sky, partly cloudy with temperatures likely in the high 50s. It sits right in the middle of a 14-day forecast in which the temperatures stay very consistent.


Rams vs. 49ers Player Props

Jimmy Garoppolo & Matthew Stafford, 250 Yards & 2 TDs Each

Odds: +500 at FOX Bet

This seems like a lot of yards for Garoppolo, but he’s thrown for over 250 in four of seven games and has averaged 263 ypg in four career games vs. the Rams (and 1.5 TDs). Pass D is an issue for L.A. As far as Stafford goes, the San Fran D is tough vs. the pass but Stafford has hit the 250-yard mark every game so far and two TDs in all but two.

George Kittle, Over 4.5 Receptions

Odds: -160 at DraftKings

Kittle returned from a four-week absence to haul in six passes for 101 yards and a TD last week. He’s finished with a season-low four receptions three times, but the Rams’ inability to cover TEs bodes well for Monday.

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Cooper Kupp & Brandon Aiyuk, 50 Receiving Yards Each

Odds: +100 at FOX Bet

No need to worry about Kupp; only once has he finished under 90 yards, and that game he still tallied 64. As for Aiyuk, he’s only hit the 50-yard mark once – but it was last week when he had a season-best six catches for 89 yards and a TD, on the field for 93% of snaps. Let’s see that trend continue vs. the 21st-ranked Rams pass D.


RELATED: NFL Week 10 Picks & Best Bets For Every Game


Rams vs. 49ers Moneyline

The Rams are at -195 on the moneyline, meaning it would take a $195 wager to win $100 in profit. Conversely, the underdog 49ers are +165 (a $100 win means $165 in profit). Most moneyline picks at sportsbooks are siding with Los Angeles despite the odds.

It makes sense. Despite the inconsistency of both sides, the Rams have shown the strong ability to score a lot of points, and the better defense. San Francisco piles up stats but it hasn’t translated to wins. Against teams that are currently 4-5 or better, the 49ers are 0-4. There isn’t any value on either side here.

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Rams vs. 49ers Point Spread

Prior to the loss to Tennessee, the Rams had won four straight, all by at least nine points. All three were against non-contenders, and the Niners at 3-5 could be considered in that group. The Niners are a terrible 2-6 against the spread this season, the lone covers both on the road as favorites.

The Niners have underachieved in the standings. They rank 13th in total offense and eighth in defense despite a losing record. The Rams have played two teams with winning records this season and are 0-2. For those looking for a little Monday night NFL betting action, taking the points with the host 49ers might be the best side, but we’re not siding with either at this point.

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Rams vs. 49ers Totals

The Over/Under for Monday Night Football sits at 49. For all the considering that San Francisco is a defense-first team, its last three games have all hit Over, and five of its last six games have finished with at least 48 points. The average Rams game has scored 51 points.

It may be slight, but each passing game has an edge here. The Under has hit in the last four meetings, but those meetings didn’t have Stafford on one side, plus the Rams’ defense has taken a slide. The Over is worth one of your NFL picks for Week 10 if you’re looking for a total to back on Monday. You can get Over 48.5 (-115) at FanDuel.

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About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com.