Adam Thompson for Bookies.com

By Adam Thompson | | 15 mins

NFL Week 2 Odds, Lines and Analysis for All 16 NFL Games

NFL Week 2 Odds, Lines and Analysis for All 16 NFL Games
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The first week of the 2021 NFL season is the first taste of high-level football for the season. Week 2 offers true litmus tests – which direction is this season trending?

There are several potentially critical matchups in the second weekend of the season, highlighted by the Sunday Night Football matchup between Patrick Mahomes and the Kansas City Chiefs against Lamar Jackson and the Baltimore Ravens. The Chiefs or Ravens have earned the No. 1 seed in the AFC Playoffs for three consecutive years. The result of that game could trigger movement in NFL futures markets at top betting sites.

That is just one of several intriguing matchups that ultimately could have implications four months down the road. Let’s take a deep dive into NFL Week 2 odds.

Week 2 NFL Games

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Best Odds
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Week 2 Games
Bet %
- -
1000
1200
- -
- -
60%
@Soldier Field - Chicago
40%
70%
@Lucas Oil Stadium - Indianapolis
30%
73%
@Tiaa Bank Field - Jacksonville
27%
73%
@Hard Rock Stadium - Miami
27%
- -
@Heinz Field - Pittsburgh
- -
64%
@Lincoln Financial Field - Philadelphia
36%
61%
@Bank of America Stadium - Charlotte, NC
39%
- -
@Metlife Stadium - East Rutherford
- -
40%
@Firstenergy Stadium - Cleveland, OH
60%
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Thursday, Sept. 16

New York Giants at Washington Football Team (-4.5), 8:20 p.m. ET

The return of Saquon Barkley was not the immediate elixir for the Giants in Week 1. He rushed for 26 yards on 10 carries – Daniel Jones rushed for more yards – in New York's 27-13 home loss. New York’s defense ranked 10th in yards allowed in 2020 and held Denver in check for most of the game. It should have a good matchup against a Washington team reeling without its starting QB.

Week 1 did not go as planned for Washington (0-1), which lost QB Ryan Fitzpatrick in the opening minutes in a 20-16 loss to the Chargers. Washington's top-ranked defense of a year ago was gashed by Justin Herbert for 337 yards and consistently failed on third-down plays. Taylor Heinicke went 11-of-15 passing in Fitzpatrick's absence, but for just 122 yards. Fitzpatrick's status for Week 2 is in question.

Take a look at Giants vs Washington odds, injury report, betting lines and more.

Sunday, Sept. 19

Cincinnati Bengals at Chicago Bears (-2.5), 1 p.m. ET

The Bengals (1-0) persevered and knocked off the Vikings as a home underdog in overtime. It wasn't the run or the pass, but both, that propelled Cincy's offense. QB Joe Burrow had just seven incompletions and no INTs (20-of-27 for 261 yards, two TDs) and Joe Mixon piled up 127 yards on the ground. Ja'Marr Chase had a heck of a debut, catching five passes for 101 yards and a TD. Could the future be now in Cincinnati?

The scuttlebutt about Justin Fields taking over at QB over Andy Dalton weren’t quieted after the season opener, a 34-14 loss to the L.A. Rams. Dalton was 27-of-38, but for only 207 yards and zero TDs (and an INT in the end zone). Field made two passes, completed them both, and ran for a score in spot duty. The defense allowed 34 points but a respectable 382 overall yards, and RB David Montgomery gained 108 yards on just 16 carries. A run-first attack didn’t work against a Bengals team that limited Dalvin Cook to 61 yards in Week 1.

Take a look at Bengals vs Bears odds, injury report, betting lines and more.

Los Angeles Rams (-4) at Indianapolis Colts, 1 p.m. ET

The Rams were hopeful that trading for Matthew Stafford in the offseason would up their QB game. Week 1 showed it did. Stafford went 20-of-26 for 321 yards, three TDs and zero INTs in the Rams’ Sunday Night Football 34-14 rout of the Bears. He really connected with Cooper Kupp (seven receptions, 108 yards) and tossed scoring throws to three different receivers. The Rams defense, which led the NFL in fewest yards allowed, bent but didn’t break, a style that worked against the conservative Andy Dalton.

The Carson Wentz Era got off to mixed results. Wentz himself was serviceable against the Seahawks – 25-of-38 for 251 yards, two TDs and no INTs – but the Indy defense had no answer for Russell Wilson and the array of weapons at his disposal in a 28-16 home loss. The Colts won the time of possession by more than 11 minutes, but they'll need to shore up their penchant for allowing the big play.

Take a look at Rams vs Colts odds, injury report, betting lines and more.

Denver Broncos (-6) at Jacksonville Jaguars, 1 p.m. ET

Denver’s defense was expected to be much-improved this season, just based on health. It looked the part in Week 1, holding Saquon Barkley to 27 yards and the Giants to 314 yards in a 27-13 road victory. Teddy Bridgewater was solid under center, going 28-of-36 for 264 yards and two TDs. The loss of playmaking WR Jerry Jeudy (ankle) is cause for some concern, but the Broncos showcased several go-to options in the opener.

Trevor Lawrence's first pro game had more misses than hits. His Jaguars trailed 27-7 to the low-potential Texans at halftime and couldn't bounce back from that. Lawrence himself tossed three TDs but also three TDs, with 332 yards. The team rushed just 16 times compared to 51 pass attempts.

Take a look at Broncos vs Jaguars odds, injury report, betting lines and more.

Las Vegas Raiders (-6) at Pittsburgh Steelers, 1 p.m. ET

Las Vegas blew a chance to win in OT despite first-and-goal from the half-yard line, but forced a Lamar Jackson fumble to beat the Ravens 33-27 in front of a wild Allegiant Stadium crowd. Derek Carr has weapons and he used them, going 34-of-56 for 435 yards – the only QB to eclipse 400 in Week 1 other than Dak Prescott. The Steelers offer another stiff challenge for the Raiders offense, though Vegas has won five of the last seven meetings of the historic AFC powerhouses.

The Steelers found a way in a come-from-behind upset win at Buffalo. They were outgained 371-251 but scored on a blocked punt and kept Josh Allen mostly in check. The lack of production from the offense should be a concern, including rookie Najee Harris' 2.8 yards per rush average.

Take a look at Raiders vs Steelers odds, injury report, betting lines and more.

San Francisco 49ers (-3) at Philadelphia Eagles, 1 p.m. ET

The Niners looked like world beaters for three quarters in building a 41-17 fourth-quarter lead. But they nearly blew it, holding on in the final seconds for a 41-33 win at Detroit. Jimmy Garoppolo had 17 completions for a big 314 yards, and Trey Lance went 1-for-1 for a score in his pro debut. The defense, however, allowed 430 yards.

Jalen Hurts' first Week 1 start couldn't have gone much better. The Eagles QB gashed Atlanta's porous pass defense, 27-of-35 for 264 yards and three TDs while rushing for 57 more yards in a 32-6 road win. The Philly defense was just as dominant, holding Matt Ryan and the potentially potent Falcons O to just 260 yards of offense.

Take a look at 49ers vs Eagles odds, injury report, betting lines and more.

Houston Texans at Cleveland Browns (-11.5), 1 p.m. ET

Many expert tabbed the Texans the worst team in football, especially when they put Deshaun Watson on the shelf. But they came out firing, built a 20-point halftime lead on the Jaguars and won 37-21 behind the arm of Tyrod Taylor. He passed for 291 yards and two TDs, and workhorse Mark Ingram rushed 26 times for 85 yards and a score. The Houston defense, meanwhile, forced three INTs from Trevor Lawrence, spoiling his pro debut.

The Browns made an opening statement against the Chiefs in Week 1 but couldn't hold on to the advantage, outscored 23-7 in the second half of a 33-29 loss. Baker Mayfield has played Cleveland into games and out of them, and that was the case here, going 21-of-28 passing for 321 yards but no TDs and a game-clinching INT. Having Nick Chubb and Kareem Hunt facing last year’s 32nd-ranked run defense has to build confidence.

Take a look at Texans vs Browns odds, injury report, betting lines and more.

New Orleans Saints (-3.5) at Carolina Panthers, 1 p.m. ET

A new, Drew Brees-less era continues in New Orleans. Step 1 couldn't have gone better, as Jameis Winston tossed five TDs and the defense dominated Aaron Rodgers in a 38-3 rout of the Packers. The Saints must contend with a healthy Christian McCaffrey, but New Orleans has won eight of the last nine meetings with its NFC South rival.

Meanwhile, Sam Darnold got the best of his old team, passing for 279 and two TDs – one passing, one rushing – in a 19-14 victory over the Jets. Carolina led 16-0 at halftime. The Panthers defense harassed QB Zach Wilson all day and held the run game to 45 yards rushing. The Panthers, who went 5-11 last year but ranked in the middle of most statistical categories, will get a real test of their potential here.

Take a look at Saints vs Panthers odds, injury report, betting lines and more.

Buffalo Bills (-4) at Miami Dolphins, 1 p.m. ET

Buffalo was a trendy pick to win the Super Bowl and was the darling of NFL pregame shows Sunday. But despite dominating Pittsburgh statistically, the Bills fizzled in a 23-16 home loss. They're not likely to overreact, however, with MVP runner-up Josh Allen under center and a defense that held the Steelers to only 251 total yards.

Miami last season went 10-6 despite and offense and defense that each ranked in the lower-half of the NFL. Week 1 followed the same script. The Dolphins were outgained 393-259, but a Patriots turnover inside the Miami 10 in the closing minutes led to a 17-16 Dolphins win at New England. They just find ways.

Take a look at Bills vs Dolphins odds, injury report, betting lines and more.

New England Patriots (-5.5) at New York Jets, 1 p.m. ET

The Patriots dominated the Dolphins and Mac Jones had a solid debut at QB, but a critical turnover and too many FGs instead of TDs led to a painful 17-16 home loss, despite outgaining Miami by nearly 150 yards. New England has bested its AFC East rival a ridiculous 18 out of 20 times, and both Jets wins in that span came in overtime.

As for the Jets, No. 2 overall pick Zach Wilson ran for his life most of the game, and drops were an issue as well in a 19-14 loss at Carolina in Week 1. Adding injury to insult, top offensive lineman Mekhi Becton was carted off with an apparent knee injury. That won't help an offense that managed only 252 yards.

Take a look at Patriots vs Jets odds, injury report, betting lines and more.

Atlanta Falcons at Tampa Bay Buccaneers (-12.5), 4:05 p.m. ET

Atlanta was thoroughly outplayed in an embarrassing 32-6 home loss to the lowly Eagles. Matt Ryan passed for just 164 yards and the pass defense, which ranked last in 2020, picked up where it left off against Jalen Hurts (264 yards, three TDs). A lot must change for a rebound in Week 2 against the reigning Super Bowl champions.

Another offseason for the 42-year-old Tom Brady didn't affect his opening game. Brady was 32-for-50 for 379 yards, four TDs and two INTs in Tampa's 31-29 win over Dallas to kick off the 2021 season. The defense was ripped by Dak Prescott but held Ezekiel Elliott to just 33 yards on the ground – does that give the Falcons a reason for guarded optimism? The odds on this game have shifted more than five points since they were first released ahead of the season.

Take a look at Falcons vs Buccaneers odds, injury report, betting lines and more.

Minnesota Vikings at Arizona Cardinals (-2.5), 4:05 p.m. ET

The Vikings entered the season as a bit of an enigma at sportsbooks, and Week 1's performance won't help matters. Twelve penalties and a critical Dalvin Cook fumble in OT doomed them in a 27-24 OT loss to the Bengals. Kirk Cousins was a masterful 36-of-49 for 351 yards and two TDs, but the team tripped itself up more often than not. The defense wasn't great, either.

It was supposed to be an offensive shootout between the Cardinals and Titans, but Arizona's defense ensured that wasn't the case. It held Derrick Henry, Ryan Tannehill and the Titans for just 251 yards of offense and DE Chandler Jones registered a whopping five sacks in shutting down Tennessee for a 38-13 win. Kyler Murray tossed a career-high four TDs, two each to DeAndre Hopkins and Christian Kirk. For fans of Arizona sports betting, it will be the first opportunity to both bet on and then root for their team in person.

Take a look at Vikings vs Cardinals odds, injury report, betting lines and more.

Tennessee Titans at Seattle Seahawks (-6), 4:25 p.m. ET

The Titans offense, with 2,000-yard rusher Derrick Henry and All-Pro WR Julio Jones, was expected to be one of the premier units in the NFL. But it managed just 251 yards and the defense was throttled in a surprising 38-13 home loss to the Cardinals. Tennessee's defense didn't help the preseason concerns, as Kyler Murray tossed a career-high four TDs against them. The Titans' defense need to figure out things in a hurry, because it doesn't get much easier in Week 2.

Russell Wilson was unstoppable at Indianapolis, with four TDs and just five incompletions in a 28-16 road win, finding Tyler Lockett twice and DK Metcalf and Gerald Everett each once in the end zone. They've now won 12 of their last 13 games with 10 a.m. Pacific Time kickoffs.

Take a look at Titans vs Seahawks odds, injury report, betting lines and more.

Dallas Cowboys at Los Angeles Chargers (-3.5), 4:25 p.m. ET

It’s great to have QB Dak Prescott back on the field. He passed for 403 yards and three TDs in Week 1, but inopportune errors doomed the Cowboys in a 31-29 last-second win by the Buccaneers. Ezekiel Elliott was a non-factor (33 yards on 11 attempts), and the defense, while it did intercept Tom Brady twice, also allowed four TDs and 379 yards through the air.

The Chargers were a top-10 team in total offense and defense, and QB Justin Herbert had one of the top rookie seasons in NFL history. Injuries and coaching doomed the 2020 season but both issues were addressed in the offseason. They opened 2021 with a 20-16 win, thanks in large part to a defense that held Washington to only 261 yards. Herbert was great, too, going 31-of-47 for 337 yards. There will be a difference between facing Prescott and not Taylor Heinicke, Washington's QB after Ryan Fitzpatrick exited early (hip).

Take a look at Cowboys vs Chargers odds, injury report, betting lines and more.

Kansas City Chiefs (-3.5) at Baltimore Ravens, 8:20 p.m. ET

The Chiefs outscored the Browns 23-7 in the second half of their four-point, Week 1 home win. This one doesn't get any easier. It isn’t a stretch to say homefield advantage could be in the mix in this Week 2 showdown, and Super Bowl odds will undoubtedly by impacted by the result.

Lamar Jackson did his thing Week 1 at Las Vegas, but the vaunted Ravens defense had no answers for the Raiders passing game in a 33-27 overtime defeat. Jackson was fine despite myriad questions at RB, rushing for a game-high 86 yards while also throwing for 235. The other side of the ball exposed big issues, however, as Derek Carr torched them for 435 yards. They better get those issues fixed quickly – Patrick Mahomes and the Chiefs are coming to town.

Take a look at Chiefs vs Ravens odds, injury report, betting lines and more.

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Monday, Sept. 13

Detroit Lions at Green Bay Packers (-10.5), 8:15 p.m. ET

The Lions' last-ranked defense of 2020 didn't show much bounce back in Week 1, allowing 442 yards in a 41-33 loss to the 49ers. Jared Goff was handed the entire offense and nearly held a historic comeback after his Lions trailed 41-17 in the fourth quarter. He finished 38-of-57 for 338 yards, three TDs and one INT, showing offensive promise if the defense can make a stop.

Rodgers looked lost, passing for just 133 yards, zero TDs and two INTs. Aaron Jones rushed just five times for nine yards, too, and the defense was gashed through the air and on the ground. Green Bay's 228 total yards was the fewest of any team in Week 1. We'll find out if that was an outlier of an effort or a precursor of things to come.

Take a look at Lions vs Packers odds, injury report, betting lines and more.

Opening Spreads vs Current Spreads

How have the Week 2 NFL spreads changed on betting apps since they were released? Here are the opening and current NFL lines via DraftKings Sportsbook.

Game matchupOpening SpreadCurrent Spread
New York Giants at Washington Football Team Washington -3.5Washington -4.5
Las Vegas Raiders at Pittsburgh Steelers Steelers -5.5Steelers -6
San Francisco 49ers at Philadelphia Eagles 49ers -549ers -3
Houston Texans at Cleveland Browns Browns -12.5Browns -12
Denver Broncos at Jacksonville Jaguars Broncos -2.5Broncos -6.5
New Orleans Saints at Carolina Panthers Saints -2.5Saints -3.5
Los Angeles Rams at Indianapolis Colts Rams -1.5Rams -4
Buffalo Bills at Miami Dolphins Bills -2.5Bills -4
New England Patriots at New York Jets Patriots -4Patriots -5.5
Cincinnati Bengals at Chicago Bears Bears -5Bears -2.5
Atlanta Falcons at Tampa Bay Buccaneers Bucs -7.5Bucs -12.5
Minnesota Vikings at Arizona Cardinals Cardinals -1.5Cardinals -2.5
Tennessee Titans at Seattle Seahawks Seahawks -4.5Seahawks -6
Dallas Cowboys at Los Angeles Chargers Chargers -1.5Chargers -3.5
Kansas City Chiefs at Baltimore Ravens Chiefs -2Chiefs -3.5
Detroit Lions at Green Bay Packers Packers -7.5Packers -10.5
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About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. Previously the sports editor of the Green Bay Press-Gazette.