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Adam Thompson for Bookies.com

By Adam Thompson | | 22 mins

NFL Week 2 Odds, Moneylines & Point Spreads For Every Game

NFL Week 2 Odds, Moneylines & Point Spreads For Every Game

Tom Brady vs. Ben Roethlisberger is over. Here comes Mac Jones vs. Mitchell Trubisky. 

Many times over the last 20 years, the New England Patriots and Pittsburgh Steelers have battled for supremacy in the AFC. Now, each team is looking to regain that status with new personnel as they match up in a Week 2 showdown, which should be an interesting one from an NFL betting perspective. 

Jones exceeded expectations in his 2021 rookie season, guiding the Patriots to a playoff berth. Jones himself was chosen as a Pro Bowl QB and finished second in NFL Rookie of the Year voting. Trubisky, the former Bears starter, is just beginning his first season in the Steel City but he’s 29-21 as a starter; Trubisky gets maligned for not doing more in Chicago, but his 58% win rate is nearly identical to Jones’ 58.8%. 

We also get some matchups we don't see very often, as there are just five divisional games in Week 2 of the NFL schedule. Joe Burrow’s Cincinnati Bengals traveling to face Dak Prescott and the Dallas Cowboys, and Cardinals vs. Raiders and Titans vs. Bills highlight the NFL Week 2 lineup. 


RELATED: NFL Week 1 Odds, Moneylines And Point Spreads For Every Game


Thursday, Sept. 15

Los Angeles Chargers at Kansas City Chiefs, 8:20 p.m. ET

If there’s one team that has figured out how to hang with Patrick Mahomes and the Chiefs, it’s the Chargers. L.A. has won two of the last four meetings, and its two defeats were in overtime. Justin Herbert has averaged 282.5 yards and 2.5 TDs in the four meetings. 

Mahomes isn’t to be outdone, however. In the three meetings the past two seasons, he’s averaging 324 yards and three TDs. Each of the past three Chargers-Chiefs games have totaled at least 54 points. With Kansas sports betting likely live in time for this matchup, Chiefs fans in the state will be able to wager on this clash of AFC West rivals. It could be a fun shootout.

Sunday, Sept. 18

Miami Dolphins at Baltimore Ravens, 1 p.m. ET

The Dolphins downed the Ravens 22-10 last season thanks to a defense that held Baltimore to 304 total yards. Now an offense in Miami that ranked 22nd in scoring and 25th in yards must improve. 

Baltimore’s defense must improve as well. After ranking top 10 in points allowed for five consecutive seasons, it was 19th in 2021. The last time Tyreek Hill faced this Baltimore defense, however, he had only three receptions for 14 yards. The Ravens have strengthened in defense and this should be a test.

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New York Jets at Cleveland Browns, 1 p.m. ET

The Browns’ vaunted 1-2 run-game punch might spell trouble for a Jets defense that was worst in the NFL in both yards and points allowed, and 29th vs. the run. The Jets should know more about its prospects after Week 1 – they could have as many as four rookie starters. 

Cleveland took care of business against overmatched opposition in 2021, going 6-3 when favored on betting apps. That number plummets to just 2-7 against the spread, however. While the rush attack was top-tier, the pass game ranked 27th. Adding Cowboys star Amari Cooper should pay off quickly but the QB situation is a concern. There is still uncertainty over Deshaun Watson's availability and after Baker Mayfield's trade to Carolina, career backup Jacoby Brissett is poised to be the Browns Week 1 starter.

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Washington Commanders at Detroit Lions, 1 p.m. ET

Washington has a lot of issues to figure out in the opening four weeks of the season, but acquiring Carson Wentz to lead the offense shows it doesn't consider this a rebuilding year. Last season the offense was near the bottom of most key stats despite Pro Bowl-caliber skill players (Terry McLaurin and Antonio Gibson) while the defense was a disaster, but just one year removed from a top-five campaign. It must bounce back.

Jared Goff has a good opportunity to begin making believers in Detroit, facing a Commanders defense that allowed 266 ypg passing last season, fourth-most. The team is also hoping to see a bounce-back season from D’Andre Swift, whose average yards per game and per reception dropped in 2021. The Lions have a good group of weapons.

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Indianapolis Colts at Jacksonville Jaguars, 1 p.m. ET

Matt Ryan doesn’t get the same love as some veteran QBs around the NFL, but he’s been just as effective. Now he gets a bona fide star RB behind him (Jonathan Taylor) and here gets an opportunity for a solid start. After facing the downtrodden Texans in Week 1, Indy gets a Jaguars squad that has four wins in the last two years. 

The Jaguars have been a doormat for most of the past decade, but they handled the Colts 26-11 when these teams faced off on Jan. 9, a shocking defeat that knocked Indy from playoff contention. Jacksonville has won eight of the last 13 matchups with Indianapolis. Something to consider when planning your wagers on betting sites for this one.

Tampa Bay Buccaneers at New Orleans Saints, 1 p.m. ET

Tom Brady has not fared well vs. the Saints over the years, and neither has Tampa Bay in general. New Orleans has won seven of eight, including a 9-0 shutout last December. That’s an anomaly for the Bucs, who have ranked No. 2 in scoring in each season with Brady at the helm. He will be without retired TE Rob Gronkowski and most likely WR Chris Godwin, who is recovering from a torn ACL.

The first year without Drew Brees didn’t go so hot for the New Orleans offense. After ranking top 5 in scoring for five straight years, the offense was 19th, while it was 28th in yards gained (it was never below 12th under Brees). New Orleans is hoping Michael Thomas will find his 2021 form and give Jameis Winston a top-level target. Jameis also has first-round draft pick Chris Olave (like Thomas, a former Ohio State receiver) to pepper with targets, too.

Carolina Panthers at New York Giants, 1 p.m. ET

Baker Mayfield has a new home in Carolina. Assuming he beats out Sam Darnold and rookie Matt Corral, he'll be starting at QB for the Panthers in Week 2. The hope is the good health of electric RB Christian McCaffrey sticks and Mayfield provides competent QB play. The Giants ranked 25th vs. the run in 2021. 

Daniel Jones went 4-7 as a starter last year with only 10 TDs; this is a make-or-break season for the New York QB, but the Panthers had the NFL’s third-best secondary last season. Saquon Barkley is back for now, but he’s managed just 15 games in two seasons. New York pounded Carolina 25-3 last season, a game Barkley didn’t play. A repeat performance would go down well for Giants fans sure to be wagering on New York betting apps this season.

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New England Patriots at Pittsburgh Steelers, 1 p.m. ET

The Patriots dominated the Steelers during the Brady vs. Roethlisberger years, but each team starts fresh. Mac Jones had a great first impression by making the Pro Bowl as a rookie. New England’s offense showed life. Only once in the last decade has New England scored under 27 vs. Pittsburgh. 

Mitchell Trubisky was 29-21 as a starter going into 2021 with a decent 64-38 TD-INT ratio, though many see the future of this offense led by RB Najee Harris. Between the trenches, few teams were this bad. The Steelers ranked 29th in running the ball and dead-last against the run. 

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RELATED: NFL Week 1 Best Bets, Predictions And Picks For Every Game


Atlanta Falcons at Los Angeles Rams, 4:05 p.m. ET

Marcus Mariota is under center but this is a touch matchup. For a team that ranked 27th or worse on both sides of the ball, facing the defending Super Bowl champions is a difficult ask. Mariota had a 7/2 TD/INT ratio in his last major action (in 2019). 

After an exciting opening Thursday night vs. the Bills to begin the defense of their Super Bowl title, this is a return to normalcy against a rebuilding opponent. If there’s some solace for Atlanta, it’s that the Rams won their last three playoff games each by only three points. But that’s not much vs. a Rams team that won the toughest division in football, and the title. 

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Seattle Seahawks at San Francisco 49ers, 4:05 p.m. ET

Russell Wilson or no, the Seahawks have had the number of their NFC West rivals, winning the last four. The last three games have been decided by a TD or less. Seattle’s defense, a mess in 2021, was boosted at the draft with at least three starters selected. They will likely be facing Trey Lance here.

Regardless of the QB, the Niners are hoping for another return trip to the postseason. When it comes to the four pillars – passing and rushing, offensively and defensively – San Francisco ranked in the top seven in three of them. In fact, the defense has been top five in yards allowed three years running. If Lance can produce solid play, the Niners will be strong again.

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Cincinnati Bengals at Dallas Cowboys, 4:25 p.m. ET

Cincy ranked 27th in pass defense last year but made it the priority to improve the secondary in the offseason. It results in upwards of five new players who should see action. The offense, meanwhile, should be fine and playing on the road doesn’t faze them – they won at Tennessee and Kansas City to get to the Super Bowl last year. Ohio sports betting will launch on Jan. 1, 2023, unfortunately not in time for Bengals fans looking to wager on this Week 2 matchup but it should be a go for the end of the regular season in the Buckeye State.

The only way to hang with the Cowboys at AT&T Stadium is to outscore them. They averaged 34.4 ppg in Big D last year, tops in the league, and led the NFL in scoring everywhere at 30.4 ppg. They did trade away Amari Cooper to the Browns but they still have plenty of weapons for Dak Prescott. The last time the Bengals won in Dallas was 1988. 

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Houston Texans at Denver Broncos, 4:25 p.m. ET

Davis Mills is likely to get the keys to the Texans offense. He wasn’t spectacular but did guide the team to four wins despite ranking dead-last in yards gained. Houston also ranked second-worst in yards allowed, so facing a motivated Denver team on the road is going to mean large NFL spreads on this one at sportsbooks.

Russell Wilson rightly gets the headlines as Denver’s biggest addition, but star DE Randy Gregory from Dallas is a strong No. 2. He should help a defense that ranked 15th vs. the run and 18th in sacks. 

Arizona Cardinals at Las Vegas Raiders, 4:25 p.m. ET

Arizona learned how to win the close ones last year, and the ones on the road. Kyler Murray and the Cards went 8-2 away from home, tied with the Rams for the best mark in the NFL. With a pass offense that ranked No. 8 and a pass defense that was No. 6, Arizona appears built for the modern NFL – and for slowing down Vegas’ pass-first attack. 

It will take every bit of that talent to slow a Vegas aerial offense that added Davante Adams to play alongside the likes of Hunter Renfrow and Darren Waller. Vegas was 5-4 last season in its new Allegiant Stadium, though three of those victories came in OT. 

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Chicago Bears at Green Bay Packers, 8:20 p.m. ET

The Bears took a step backward after replacing Mitchell Trubisky with rookie Justin Fields at QB, but the hope is Year Two goes a little better. Chicago attacked its key weaknesses in the draft, adding two starters in the secondary and as many as five two-deep offensive linemen. 

For being one of the most-heated rivalries in sports, it hasn’t been much of a rivalry lately. The Packers have won 23 of the last 27 meetings between the two, including six in a row. The last four have been by an average of 15 points. Aaron Rodgers has 61 TDs and just 10 INTs vs. Chicago in his career. It’s ridiculous. 

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Monday, Sept. 19

Tennessee Titans at Buffalo Bills, 7:15 p.m. ET

The Buffalo Bills enter the 2022 season as the favorites to win Super Bowl 57 on NFL futures markets thanks to an offense that averaged nearly 30 ppg and returns everyone, and an improving defense that added elite playmaker Von Miller. Buffalo ranked No. 1 vs. the pass in 2021. 

The Bills had few weaknesses last season but were simply average vs. the run. Derrick Henry was on track to break rushing records before injury derailed his quest. This should be a high-scoring game. Last season, the Titans won a 34-31 home shootout. The Titans will need to rely on Henry with AJ Brown now playing for the Eagles.

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Minnesota Vikings at Philadelphia Eagles, 8:30 p.m. ET

Minnesota missed the playoffs for a second consecutive season in 2021, costing head coach Mike Zimmer his job. The Vikings have three postseason appearances in the past eight years, but they’ve never finished worse than 7-9. A defense that’s ranked bottom-five in yards allowed the last two years is the big culprit.

Philly is giving it a go with dual-threat QB Jalen Hurts, who accounted for 26 TDs and led Philly to the playoffs last year. The Eagles haven’t ranked higher than 12th in scoring or scoring defense since 2017, so there is room for improvement. AJ Brown should boost a receiving corps looking for a second-year leap from last year's draft pick DeVonta Smith.

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Opening NFL Lines vs Current Lines

Here's a look at the opening NFL spreads for each game and how the lines have moved ahead of Week 2:

Week 2 MatchupOpening LineCurrent Line
Chargers vs ChiefsChiefs -3 Chiefs -3
Colts vs JaguarsColts -6.5 Colts -4.5
Jets vs BrownsUnavailableUnavailable
Dolphins vs RavensRavens -4 Ravens -4
Buccaneers vs SaintsBucs -4 Bucs -4
Patriots vs SteelersPatriots -1 Patriots -1
Panthers vs GiantsGiants -2.5 Giants -1
Commanders vs LionsCommanders -3 Commanders -1.5
Seahawks vs 49ers49ers -8 49ers -8
Falcons vs RamsRams -13.5 Rams -13
Texans vs BroncosBroncos -10 Broncos -10.5
Cardinals vs RaidersRaiders -4.5 Raiders -2.5
Bengals vs CowboysPK Cowboys -1.5
Bears vs PackersPackers -7.5 Packers -9.5
Titans vs BillsBills -7 Bills -7
Vikings vs EaglesEagles -2.5 Eagles -2.5

Current NFL lines up-to-date as of July 10, 2022 and via DraftKings Sportsbook

About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been estabilshed as one of the nation's premier NFL and MLB handicappers, and his horse racing and PGA picks have produced major winners over the last 12 months.