Tom Brady vs. Ben Roethlisberger is over. Here comes Mac Jones vs. Mitchell Trubisky. The NFL Week 2 odds peg the Pats as narrow favorites (-1).

Many times over the last 20 years, the New England Patriots and Pittsburgh Steelers have battled for supremacy in the AFC. Now, each team is looking to regain that status with new personnel as they match up in a Week 2 showdown, which should be an interesting one from an NFL betting perspective. 

Jones exceeded expectations in his 2021 rookie season, guiding the Patriots to a playoff berth. Jones himself was chosen as a Pro Bowl QB and finished second in NFL Rookie of the Year voting. Trubisky, the former Bears starter, is just beginning his first season in the Steel City but he’s 29-21 as a starter; Trubisky gets maligned for not doing more in Chicago, but his 58% win rate is nearly identical to Jones’ 58.8%. 

We also get some NFL Week 2 odds matchups we don't see very often, as there are just five divisional games in Week 2 of the NFL schedule. Joe Burrow’s Cincinnati Bengals traveling to face the Dallas Cowboys, and Cardinals vs. Raiders and Titans vs. Bills highlight the NFL Week 2 odds lineup. 

RELATED: NFL Week 1 Odds, Moneylines And Point Spreads For Every Game

NFL Week 2 Odds & Point Spreads

Let's take a look at the NFL Week 2 odds, where you can compare spreads, moneylines and Over/Unders for every game. Don't forget to compare all the odds at your favorite sportsbooks before wagering on the NFL Week 2 action.

Date	Spread	Moneyline	Over/Under
Thu, Sept 15	Chargers (+3.5) at Chiefs	Chargers +160, Chiefs -190	54.5
Sun, Sept 18	Commanders (+1.5) at Lions	Commanders +114, Lions -134	49.5
Sun, Sept 18	Jets (+6.5) at Browns	Jets +210, Browns -255	40.5
Sun, Sept 18	Bucs (-2.5) at Saints	Bucs -158, Saints +134	44.5
Sun, Sept 18	Panthers (+2.5) at Giants	Panthers +118, Giants -138	42.5
Sun, Sept 18	Patriots (-1) at Steelers	Patriots -108, Steelers -108	40.5
Sun, Sept 18	Colts (-4.5) at Jags	Colts -205, Jags +172	46.5
Sun, Sept 18	Dolphins (+3.5) at Ravens	Dolphins +154, Ravens -184	44.5
Sun, Sept 18	Falcons (+10.5) at Rams	Falcons +420, Rams -560	47.5
Sun, Sept 18	Seahawks (+8.5) at 49ers	Seahawks +315, 49ers -400	42.5
Sun, Sept 18	Bengals (-6.5) at Cowboys	Bengals -300, Cowboys +245	43.5
Sun, Sept 18	Texans (+10.5) at Broncos	Texans +385, Broncos -500	43.5
Sun, Sept 18	Cardinals (+5.5) at Raiders	Cardinals +198, Raiders -240	51.5
Sun, Sept 18	Bears (+9.5) at Packers	Bears +360, Packers -460	42.5
Mon, Sept 19	Titans (+9.5) at Bills	Titans +330, Bills -420	49.5
Mon, Sept 19	Vikings (+1.5) at Eagles	Vikings +102, Eagles -120	52.5

Odds via FanDuel and accurate as of publication.

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Thursday, Sept. 15

Los Angeles Chargers at Kansas City Chiefs, 8:20 p.m. ET

If there’s one team that has figured out how to hang with Patrick Mahomes and the Chiefs, it’s the Chargers. L.A. has won two of the last four meetings, and its two defeats were in overtime. Justin Herbert has averaged 282.5 yards and 2.5 TDs in the four meetings. His offensive line looks much improved heading into the 2022 season and they came out unscathed from a test in Week 1 against the Raiders.

Mahomes isn’t to be outdone, however, and the Chiefs looked great in dismantling Arizona in Week 1. In the three meetings the past two seasons between the Chargers and Chiefs, Mahomes is averaging 324 yards and three TDs. Each of the past three Chargers-Chiefs games have totaled at least 54 points. With Kansas sports betting live as of Sept. 1, Chiefs fans in the state can wager on this clash of AFC West rivals. It could be a fun shootout, and the latest NFL Week 2 odds have this as the highest total on the slate (54.5).

Sunday, Sept. 18

Miami Dolphins at Baltimore Ravens, 1 p.m. ET

The Dolphins downed the Ravens 22-10 last season thanks to a defense that held Baltimore to 304 total yards. Now an offense in Miami that ranked 22nd in scoring and 25th in yards must improve. There are lots of new pieces in place, including Tyreek Hill and Chase Edmonds.

Baltimore’s defense must improve as well. After ranking top 10 in points allowed for five consecutive seasons, it was 19th in 2021. The last time Hill faced this Baltimore defense, however, he had only three receptions for 14 yards. The Ravens have strengthened in defense and this should be a test after they held the lowly Jets to 9 points in Week 1.

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New York Jets at Cleveland Browns, 1 p.m. ET

The Browns’ vaunted 1-2 run-game punch might spell trouble for a Jets defense that was worst in the NFL in both yards and points allowed, and 29th vs. the run. Cleveland took care of business against overmatched opposition in 2021, going 6-3 when favored on betting apps. That number plummets to just 2-7 against the spread, however. 

While the rush attack was top-tier, the pass game ranked 27th. Adding Cowboys star Amari Cooper should pay off quickly but the QB situation is a concern. Jacoby Brissett did enough in Week 1 to edge out a win over the Panthers but Cooper was a non-factor. The Jets' QB situation is also murky, after Zach Wilson underwent knee surgery for an injury picked up in Week 1 of the preseason. Joe Flacco struggled under center in Week 1 for the Jets.

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Washington Commanders at Detroit Lions, 1 p.m. ET

Washington has a lot of issues to figure out in the opening four weeks of the season, but acquiring Carson Wentz to lead the offense shows it doesn't consider this a rebuilding year. Last season the offense was near the bottom of most key stats despite Pro Bowl-caliber skill players (see: Terry McLaurin) while the defense was a disaster, but just one year removed from a top-five campaign. It must bounce back. There were positive signs in a Week 1 win over Jacksonville.

Jared Goff has a good opportunity to begin making believers in Detroit, facing a Commanders defense that allowed 266 ypg passing last season, fourth-most. The team is also hoping to see a bounce-back season from D’Andre Swift, whose average yards per game and per reception dropped in 2021. He certainly impressed in Week 1 against the Eagles, but once again the Lions fell just short, losing 38-35.

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Indianapolis Colts at Jacksonville Jaguars, 1 p.m. ET

Matt Ryan doesn’t get the same love as some veteran QBs around the NFL, but he’s been just as effective. Now he gets a bona-fide star RB behind him (Jonathan Taylor). But Week 1 was a humbling experience for the heavily-favored Colts, who were held to a 20-20 tie by the Texans. They need a response here. 

The Jaguars have been a doormat for most of the past decade, but they handled the Colts 26-11 when these teams faced off on Jan. 9, a shocking defeat that knocked Indy from playoff contention. Jacksonville has won eight of the last 13 matchups with Indianapolis. Something to consider when planning your wagers on betting sites for this one.

Tampa Bay Buccaneers at New Orleans Saints, 1 p.m. ET

Tom Brady has not fared well vs. the Saints over the years, and neither has Tampa Bay in general. New Orleans has won seven of eight, including a 9-0 shutout last December. That’s an anomaly for the Bucs, who have ranked No. 2 in scoring in each season with Brady at the helm. He will be without retired TE Rob Gronkowski and WR Chris Godwin, who returned in Week 1 from an ACL tear but then picked up a hamstring problem.

The first year without Drew Brees didn’t go so hot for the New Orleans offense. After ranking top 5 in scoring for five straight years, the offense was 19th, while it was 28th in yards gained (it was never below 12th under Brees). New Orleans is hoping Michael Thomas will find his 2021 form (two TDs in Week 1 vs. the Falcons was a good start) and give Jameis Winston a top-level target. Jameis also has first-round draft pick Chris Olave (like Thomas, a former Ohio State receiver) to pepper with targets, too.

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Carolina Panthers at New York Giants, 1 p.m. ET

Baker Mayfield has a new home in Carolina and he's the QB1. The hope is the good health of electric RB Christian McCaffrey sticks and Mayfield provides competent QB play. He did OK in Week 1 vs. the Browns but the Panthers were beaten by a last-gasp field goal. The Giants ranked 25th vs. the run in 2021. 

Daniel Jones went 4-7 as a starter last year with only 10 TDs; this is a make-or-break season for the New York QB, but the Panthers had the NFL’s third-best secondary last season. Saquon Barkley is back as he proved with a monster Week 1 performance in Tennessee, but he’s managed just 15 games in two seasons. New York pounded Carolina 25-3 last season, a game Barkley didn’t play. A repeat performance would go down well for Giants fans sure to be wagering on New York betting apps this season.

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New England Patriots at Pittsburgh Steelers, 1 p.m. ET

The Patriots dominated the Steelers during the Brady vs. Roethlisberger years, but each team starts fresh. Mac Jones had a great first impression by making the Pro Bowl as a rookie. New England’s offense showed life. Only once in the last decade has New England scored under 27 vs. Pittsburgh. They'll need more than the limp effort they put forth in Week 1 vs. the Dolphins.

Mitchell Trubisky was 29-21 as a starter going into 2021 with a decent 64-38 TD-INT ratio, though many see the future of this offense led by RB Najee Harris. Between the trenches, few teams were this bad. The Steelers ranked 29th in running the ball and dead-last against the run. But they stunned the Bengals in Week 1, as Chris Boswell hit the game-winner in OT. A foot injury suffered by Harris is a concern.

RELATED: NFL Week 1 Best Bets, Predictions And Picks For Every Game

Atlanta Falcons at Los Angeles Rams, 4:05 p.m. ET

Marcus Mariota is under center but this is a tough matchup. For a team that ranked 27th or worse on both sides of the ball, facing the defending Super Bowl champions is a difficult ask. Mariota had a 7/2 TD/INT ratio in his last major action (in 2019). Kyle Pitts and Drake London are promising young pass catchers for Mariota, who lost his Week 1 opener in a heartbreaker (26-27 to the Saints).

After a disappointing opening to their Super Bowl title defense in Week 1 vs. the Bills, this is a return to normalcy against a rebuilding opponent. If there’s some solace for Atlanta, it’s that the Rams won their last three playoff games each by only three points. But that’s not much vs. a Rams team that won the toughest division in football, and the title. The NFL Week 2 odds peg this as the biggest mismatch of the week (Atlanta, +10.5).

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Seattle Seahawks at San Francisco 49ers, 4:05 p.m. ET

Russell Wilson or no, the Seahawks have had the number of their NFC West rivals, winning the last four. The last three games have been decided by a TD or less. Seattle’s defense, a mess in 2021, was boosted at the draft with at least three starters selected. They will be facing Trey Lance here in NFL Week 2, but may be without second-round draft pick Kenneth Walker, who has a hernia injury.

Even with Lance at QB, the Niners are hoping for another return trip to the postseason. But it did not go so well in Week 1, a surprise defeat to the lowly Chicago Bears. When it comes to the four pillars – passing and rushing, offensively and defensively – San Francisco ranked in the top seven in three of them. In fact, the defense has been top five in yards allowed three years running. They just need solid play from Lance. Otherwise it could be Jimmy G time pretty soon.

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Cincinnati Bengals at Dallas Cowboys, 4:25 p.m. ET

Cincy ranked 27th in pass defense last year but made it the priority to improve the secondary and O-Line in the offseason. The results were mixed in a shock Week 1 loss to divisional rivals Pittsburgh. Ohio sports betting will launch on Jan. 1, 2023, unfortunately not in time for Bengals fans looking to wager on this Week 2 matchup but it should be a go for the end of the regular season in the Buckeye State.

The Cowboys are in crisis after a 19-3 Week 1 defeat to Tampa Bay that saw QB Dak Prescott exit the game with a fractured thumb. He faces up to eight weeks out. The NFL Week 2 line has swung from Bengals +2.5 to Bengals -6.5 as a result.  

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Houston Texans at Denver Broncos, 4:25 p.m. ET

Davis Mills is likely to keep the keys to the Texans offense for a while. He wasn’t spectacular last year but did guide the team to four wins despite ranking dead-last in yards gained. And Houston earned a creditable 20-20 tie against Indianapolis in Week 1. But facing a motivated Denver team on the road is going to mean large NFL spreads on this one at sportsbooks.

Russell Wilson rightly gets the headlines as Denver’s biggest addition, but star DE Randy Gregory from Dallas is a strong No. 2. He should help a defense that ranked 15th vs. the run and 18th in sacks. The Broncos should be too powerful here and the NFL Week 2 odds for that game reflect that.

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Arizona Cardinals at Las Vegas Raiders, 4:25 p.m. ET

Arizona learned how to win the close ones last year, and the ones on the road. Kyler Murray and the Cards went 8-2 away from home, tied with the Rams for the best mark in the NFL. That's good news because Arizona was thoroughly out-played in its home opener, losing 44-21 to the Chiefs in Week 1.

It will take every bit of that talent to slow a Vegas aerial offense that added Davante Adams to play alongside the likes of Hunter Renfrow and Darren Waller. Vegas was 5-4 last season in its new Allegiant Stadium, though three of those victories came in OT. This is another game with shootout potential and the total (51.5) reflects that. The Raiders need a win after going down to the Chargers in Week 1.

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Chicago Bears at Green Bay Packers, 8:20 p.m. ET

The Bears took a step backward after replacing Mitchell Trubisky with rookie Justin Fields at QB, but the hope is Year Two goes a little better. It certainly started well with a win over San Francisco in Week 1. Chicago attacked its key weaknesses in the draft, adding two starters in the secondary and as many as five two-deep offensive linemen. 

For being one of the most-heated rivalries in sports, it hasn’t been much of a rivalry lately. The Packers have won 23 of the last 27 meetings between the two, including six in a row. The last four have been by an average of 15 points. Aaron Rodgers has 61 TDs and just 10 INTs vs. Chicago in his career. It’s ridiculous.

Monday, Sept. 19

Tennessee Titans at Buffalo Bills, 7:15 p.m. ET

The Buffalo Bills enter the 2022 season as the favorites to win Super Bowl 57 on NFL futures markets thanks to an offense that averaged nearly 30 ppg and returns everyone, and an improving defense that added elite playmaker Von Miller. Buffalo ranked No. 1 vs. the pass in 2021. It also just crushed the defending champions 31-10 on the road.

The Bills had few weaknesses last season but were simply average vs. the run. Derrick Henry was on track to break rushing records before injury derailed his quest. This should be a high-scoring game. Last season, the Titans won a 34-31 home shootout. The Titans will need to rely on Henry with AJ Brown now playing for the Eagles.

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Minnesota Vikings at Philadelphia Eagles, 8:30 p.m. ET

Minnesota missed the playoffs for a second consecutive season in 2021, costing head coach Mike Zimmer his job. The Vikings have three postseason appearances in the past eight years, but they’ve never finished worse than 7-9. A defense that’s ranked bottom-five in yards allowed the last two years is the big culprit. It has started well, holding Aaron Rodgers and the Packers to just 7 points in the Vikings' Week 1 win (23-7).

Philly is giving it a go with dual-threat QB Jalen Hurts, who accounted for 26 TDs and led Philly to the playoffs last year. The Eagles haven’t ranked higher than 12th in scoring or scoring defense since 2017, so there is room for improvement. AJ Brown is clearly Hurts' main man already, leading the team in targets and catches in Philly's Week 1 win in Detroit.

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Opening NFL Week 2 Lines vs Current Lines

Here's a look at the opening NFL Week 2 spreads for each game and how the lines have moved ahead of Week 2. This page will be updated frequently.

Current NFL lines up-to-date as of Sept. 12, 2022 and via DraftKings Sportsbook