NFC contenders face off on Sunday Night Football for Week 3 of the NFL season, when Aaron Rodgers and the Green Bay Packers head west to face Jimmy Garoppolo and the San Francisco 49ers.

The Packers rebounded from their Week 1 trouncing by the Saints to cruise past the Lions 35-17 last Sunday, while the Niners are 2-0 with nail-biting wins over the Lions and Eagles. Betting sites and most betting apps have San Francisco at -3.5 in the latest Packers vs. 49ers NFL spreads range for this primetime showdown.

Take a look at Packers vs 49ers odds, injury report, betting lines and more.

RELATED: NFL Week 3 Odds & Analysis For All 16 Games

Packers vs. 49ers Key Matchups

Aaron Jones vs. 49ers Pass D: Jones caught six passes for 48 yards and three TDs. San Francisco’s defense has allowed the second-most receptions to RBs through two weeks.

49ers O-line vs. Packers D-line: The Niners have allowed one QB sack through two games. The Packers have only one sack this season.

49ers vs. Expectations: The 49ers win games, but against the spread is a different story. San Francisco is a brutal 8-17-2 ATS under coach Kyle Shanahan.

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5 Key Packers vs. 49ers Stats

9.1: The yards per pass attempt of Jimmy Garoppolo, seventh-highest in the NFL and the highest of Garoppolo’s eight-year career.

18: Touchdowns in eight games by QB Aaron Rodgers against his hometown 49ers, compared to only two INTs.

20: Targets in the 49ers pass game for Deebo Samuel, 11 more than anyone else on the team. His 282 yards (on 15 receptions) is nearly triple anyone else.

21: Total yards fewer for the Packers than the Lions, despite winning the game 35-17. Turnovers proved to be a big difference.

30: Since 2015, the winning team in every game played between the 49ers and Packers has scored at least 30 points.

RELATED: NFL Week 3 Picks & Best Bets To Make

Packers vs. 49ers Player Props To Consider

George Kittle, Over 60.5 Receiving Yards

Odds: -105 at FOX Bet

The Packers have had zero success stopping tight ends. Saints TEs caught six passes for a modest 39 yards but also two TDs. The Lions’ TJ Hockenson had eight receptions for 66 yards and also scored. Kittle has played second fiddle to Deebo Samuel, but with Jaire Alexander guarding Samuel, Kittle should get more action.

George Kittle, Score TD

Odds: +130 at FanDuel

See above. Green Bay has allowed three TDs to tight ends through two games. The Niners should look to get Kittle going and this is a great opponent to do so.

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Aaron Rodgers, Longest Pass Over 36.5 Yards

Odds: -115 at DraftKings

Rodgers likes the long ball. He led the NFL in long pass yards last year and the second-most attempts downfield. The Niners allowed passes longer than that vs. both the Lions and Eagles.

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Aaron Jones, 50 Yards Rushing & 25 Yards Receiving

Odds: +200 at FOX Bet

Jones had 67 yards rushing and 48 yards receiving – plus four TDs – in Week 2 at Detroit. The Niners’ defense offers more resistance, but Jones is going to get carries and was No. 2 in targets. Odds offer value.

AJ Dillon, Over 18.5 Rushing Yards

Odds: -120 at DraftKings

Dillon averages exactly 18.5 yards per game through two weeks, but the Packers want to get him the ball more. He averages 4.1 yards per carry, better than the 3.5 of Aaron Jones. Niners opponents are averaging 5.0 yards per attempt.

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Packers vs. 49ers Weather Forecast

Sunday night should be clear and calm in the Bay Area. Temperatures during the day are only expected to reach the low 60s, with gametime temps in the upper 50s. Skies should be rain-free at Levi’s Stadium.

Packers vs. 49ers Moneyline

When it comes to NFL betting on the moneyline, the Packers have had the upper hand in the regular season lately, with the Niners gaining the important postseason edge.

For Sunday Night, the 49ers are -200 on the moneyline, the Packers are +170. Getting Aaron Rodgers and an offense that was clicking vs. the Lions is enticing. But both teams scored 30-plus on Detroit this season. The other games saw each offense struggle, and each defense has been inconsistent. Going against the Pack at a cost of -200 is too pricey. If there’s a side to take, it’s with Green Bay at +170 with DraftKings . But that isn’t the most-appetizing course for SNF.

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Packers vs. 49ers Point Spread

The 49ers are favored by 3.5 points, the hook daring bettors to back the Pack plus points. So is the trend that San Francisco has covered the spread in just two of its last 10 home games. Its last three home openers have been decided by 3-4 points, so that doesn’t help picking a side. It was 0-3 ATS when favored by 3.5 or more points.

If there’s an edge to be found, it may be the Niners’ lack of a ground game. They could be without their top four RBs. Much is to be determined on the status of several backs, however. SF has run the ball regardless of personnel, and Green Bay has struggled to slow the run. Still, the hook keeps us off the Niners, and Week 1 keeps us off the Pack.

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Packers vs. 49ers Totals

NFL sportsbooks have posted an Over/Under of 49 points for Week 3 Sunday Night Football, up a point from the opening line. The last four matchups have averaged 54 ppg and three of the last four games between these teams have totaled at least 51. But when it comes to picking a side to add to your Week 3 NFL picks, this might be a stayaway.

Consistency hasn’t been strong for either side. In two games so far, the 49ers have totaled 41 and 17 points, the Packers 3 and 35. The defenses have similar trends. The Over has hit in nine of the last 12 meetings, but it’s best to stay away from this middle-of-the-road total.

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