The once-promising start of the Carolina Panthers and new quarterback Sam Darnold has gone further south than … well … Carolina. The New York Giants sunk to the depths of the NFL right off the bat and have remained there.

The Giants are an NFC East-worst 1-5 and have lost two in a row. Carolina is treading water at 3-3 following a 3-0 start. Still, it’s the Panthers who will take the field Sunday at MetLife Stadium as the 3-point road favorite. How does that impact our NFL picks?

Take a look at Panthers vs Giants odds, injury report, betting lines and more.

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Panthers vs Giants Key Matchups

Chuba Hubbard vs Giants Run Defense: Carolina is 0-3 since losing All-Pro running back Christian McCaffrey to a hamstring injury. The Panthers have gone away from the run minus McCaffrey, but head coach Matt Rhule vows to rectify that this week. That should mean plenty of work for rookie Hubbard. He went for 61 yards and a TD on 16 carries last week.

Who Wins The Turnover Battle? Or should that be who doesn’t win the turnover battle? The Panthers have turned the ball over eight times during their three-game losing. The Giants committed six turnovers in the past two weeks.

Darnold vs New York: Darnold has already beaten the New York Jets, his old team, in Week 1. Now he gets the chance to complete the New York double back at the stadium he once called home. Darnold is 8-13 at MetLife Stadium but 1-0 there against the Giants.

In list form, 3 key matchups that bettors should know and keep an eye on when wagering on the game

5 Key Panthers vs Giants Stats

31: Average times the Panthers rushed the ball in their three victories. They ran it an average of 26.5 times in their three losses.

28: Points given up by the Giants in the second quarter of last week’s 38-11 loss to the Los Angeles Rams. That’s the most scored against them in one quarter since the Philadelphia also put up 28 on Dec. 19, 2010.

12: Sacks of Darnold over the past three games. He was sacked three times in Carolina’s three victories.

10: Passes caught last week by Giants WR Sterling Shepherd. That was his best game since 2018.

6: Interceptions thrown by Darnold in the past three games. He was picked off once during the first three games.

Panthers vs Giants Weather Forecast

The football might not be beautiful to watch between the Giants and Panthers, but no one will be able to complain about the conditions. The weather forecast is calling for a very pleasant late-October Sunday. Expect clear skies and sunshine, 11 mph wind conditions and a temperature of 53 degrees.

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Panthers vs Giants Player Props

Panthers WR DJ Moore, Over 87.25 receiving yards

Odds: -115 at BetMGM ➜

In two road games this season, Moore went over 100 yards both times.

Panthers QB Sam Darnold, Over 236 passing yards

Odds: -105 at Caesars Sportsbook ➜

Darnold beat this total in each of his first four games this season.

Panthers WR Robbie Anderson, Over 45.5 receiving yards

Odds: -110 at Caesars Sportsbook ➜

Back in the stadium he called home with the Jets, Anderson is due for a breakout game.

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Panthers vs Giants Moneyline

Carolina has won three straight games from the Giants. The Panthers have also taken two of the last three games played between the two teams at MetLife Stadium. Overall, Carolina is 4-2 straight up on the road when facing the Giants.

The Panthers have held the Giants under 10 points in two of those victories at New York. They haven’t lost anywhere to the Giants since 2012. New York is 1-5 over the past six home games. Carolina is 2-2 over the past four road games. Carolina is the pick at sportsbooks in this game. Look for the Panthers to rebound from their recent struggles. Play them at -160 at BetMGM. ➜

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Panthers vs Giants Point Spread

The Panthers are the epitome of the streaky team, as evidenced by their performance in the NFL spreads market so far this season. Carolina opened the season 3-0 straight up and 3-0 against the spread. In their last three games, the Panthers are 0-3 SU and 0-3 ATS.

Carolina is 1-0 ATS as an away favorite and 1-1 overall ATS in away games. The Giants, meanwhile, are just all kinds of bad when it comes to NFL betting this season. They are 2-4 ATS, 0-2 ATS as a home underdog and 0-3 ATS overall at home.

They’re the perfect remedy to fix what ails the Panthers. Take Carolina and lay the three points at DraftKings. ➜

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Panthers vs Giants Totals

Not only have the Giants lost two in a row, they’ve surrendered 82 points in the process. They’ve given up at least 27 points in four games and more than 30 in three games. The Giants are 3-2-1 on the total this season at betting sites. Carolina leans more toward the under at 2-4 on the total.

New York isn’t a strong home Over play, though. The Giants are 0-2-1 at MetLife Stadium on the total. On the road, Carolina’s over record this season is 1-1. The Panthers are the No. 16 scoring offense in the NFL (23.8 points per game). The Giants are No. 27 in scoring offense (19.0 ppg). Go with the Under on the total of 43 points being offered by betting apps.