A trip to the Super Bowl hangs in the balance as NFC West rivals face off for the third time this season in one of the bigger games in each franchise’s history.

Matthew Stafford and the Los Angeles Rams host Jimmy Garoppolo and the San Francisco 49ers on Sunday at 6:30 p.m. ET, the winner returning to SoFi Stadium two weeks later for Super Bowl 56.

The 49ers beat the Rams in overtime in the final game of the regular season just to get into the NFL Playoffs, but two upsets later they’re back. They handled the Rams 31-10 in San Fran back in Week 11. Betting sites and most betting apps have Los Angeles at -3.5 in the latest 49ers vs. Rams NFL spreads range.

Take a look at Rams vs 49ers odds, injury report, betting lines and more.

49ers Vs Rams Key Matchups

Tyler Higbee vs. 49ers LBs: The Niners rank No. 2 in the NFL in yards allowed to tight ends and gave up just six TDs to the position. Higbee, however, has three of those scores and a season-high six receptions for 55 yards in Week 18.

Matthew Stafford vs. 49ers DBs: The Rams QB tossed two INTs in each regular-season loss to the Niners. His yards in those games (238 and 243) ranked as his third- and fourth-fewest of the season.

Deebo Samuel vs. Rams Defense: The first meeting between the teams was the first Deebo was featured out of the backfield. He totaled 133 and 140 yards in the games vs. L.A. and the 49ers are 9-1 since the transition.

5 Key 49ers Vs Rams Stats

16: Passing TDs to receivers, allowed by the Rams this season. Only the Bills allowed fewer.

19.7: The points per game allowed at home by the Rams, the 11th-lowest mark in the NFL. Ironically, the Niners on the road allow 19.7 ppg, too, sixth-lowest.

85.7: The win percentage of the 49ers at Los Angeles since the Rams relocated from St. Louis. They’re 6-1 including three straight.

120: The yards per game against the 49ers for Rams WR Cooper Kupp. He had 11 receptions for 122 yards in the first meeting and seven for 118 in the second.

141.7: The QB rating of Jimmy Garoppolo vs. the Rams in Week 10. That was the top rating for the QB all season and the 49ers won that game 31-10.

RELATED: NFC & AFC Conference Championship Picks & Predictions

49ers Vs. Rams Weather Forecast

It’ll be as good as it gets in L.A. on Sunday evening. Highs that day should touch the lower-70s, with sunny skies and no chance of rain. The lows that evening could dip to around 50 degrees, but still very manageable. Of course, if there were any weather elements, it wouldn’t matter under the roof of SoFi Stadium.

49ers vs. Rams Player Props

Jimmy Garoppolo, Over 230.5 Pass Yards

Odds: -115 at BetMGM

Garoppolo hasn’t gone over 200 yards in the 49ers’ two big playoff wins. But if he’s asked to do more, he can, and he might here vs. a No. 6-ranked L.A. run defense. The previous five 49ers games, he eclipsed 295 in four of them. He’s capable.

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Cooper Kupp, Over 101.5 Receiving Yards

Odds: -115 at DraftKings

Kupp has gone well over this total in both games vs. SF this season and only the Cardinals have held him under 92 yards. Expect the Rams to be throwing and expect Matthew Stafford to look the way of the NFL’s top receiver all evening.

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Most Receiving Yards, Cooper Kupp

Odds: -150 at FanDuel

Kupp leads pretty much every game in receiving, and here faces a Niners team that will run as often as they’re allowed. Odell Beckham Jr. has ranged anywhere from 81 to 7 yards for the Rams. Kupp is consistently exceptional.

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49ers Vs. Rams Moneyline

When it comes to NFL betting on the moneyline, Los Angeles is favored -170 on the moneyline, while San Francisco is set at +150. The underdog Niners won both regular-season meetings.

On paper, one could argue the veteran Rams have the advantage, with the NFL’s top receiver, several of the premier 1-on-1 defenders, and a QB who produces. That said, the Niners took care of business in both meetings, overall have been far more consistent and, statistically speaking, have matchup advantages.

If you think it comes down to the QBs, the Rams make sense. Otherwise, one can’t argue with the other avenues. The 49ers offer some value on the moneyline but we’re not going with either side.

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49ers Vs. Rams Point Spread

The Rams are favored by 3.5 points despite getting swept in two regular season meetings. The Niners have won nine of eleven with both losses by a TD or less, covering in their last four games. They’re also on a 5-0 ATS run as an underdog, including both games vs. the Rams.

The two pressing questions are, do you trust Jimmy Garoppolo, and does it matter? The Niners are 8-3 when Jimmy G tosses 0-1 TDs and 3-3 when it’s two (he didn’t throw three in any game). In the playoffs, he has zero TDs and two INTs, yet here they are. There’s more proof in the Niners’ pudding, and we love getting a hook. Back San Francisco at +3.5.

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49ers vs. Rams Totals

NFL sportsbooks have posted an Over/Under of 46.5 points for this Sunday afternoon showdown. It’s a full touchdown less than the AFC Championship and in the middle of the previous two games between these teams, which totaled 51 and 41 points.

Familiarity typically brings a strong defensive plan, and the Niners’ defense has been great anyway, holding the Packers to ten and Cowboys to seventeen the last two weeks. Five of the last six games have totaled 44 or less. Conversely, five of the last seven Rams games have been over 50, with the other two finishing in the 30s.

The Under has trended in Rams home games and in all Niners games, and it’s the way to go here in Game 3 between rivals who know each other well. Lock in the Under as part of your NFL picks package for the NFC Championship.

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