The Tampa Bay Buccaneers looked more like themselves last week. The Indianapolis Colts looked more like world beaters. While the reigning Super Bowl champion Buccaneers were putting a 30-10 whipping on the woeful New York Giants, Indy went into Buffalo and absolutely smacked around the Bills to the tune of 41-15.

At 7-3, Tampa Bay leads the NFC South. At 6-5, Indy is 5-1 in the last six games after opening the season 1-4. Still, it’s the visiting Buccaneers that sportsbooks like in the NFL picks as 3-point road favorites.

Take a look at Colts vs. Buccaneers odds, injury report, betting lines and more.

Buccaneers vs Colts Key Matchups

Colts Banged-up Secondary vs Buccaneers depth of receivers: Indy started a pair of backup safeties and got away with it against Buffalo. Can they cover all of the receiving options available to Bucs QB Tom Brady? Mike Evans, Chris Godwin and Rob Gronkowski went over 65 yards receiving in the win against the Giants.

Jonathan Taylor vs Tampa Bay’s NFL-best run defense: Indy’s Taylor dismantled Buffalo’s No. 3 run defense last week. The NFL rushing leader finished the day with five TDs. In his last six games, Taylor has run for 795 yards. That would be good enough for fourth in the NFL. Tampa Bay, though, is the top run-stopping defense in the league. The Bucs are holding teams to 78.4 yards per game on the ground.

Battle of the Opportunistic Defenses: The Colts have made an NFL-leading 25 takeaways. With 18 takeaways, the Bucs aren’t far behind. Brady’s coughed up five of his eight interceptions and two of his three fumbles on the road.

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5 Key Buccaneers vs Colts Stats

2-3: Tampa Bay’s road record this season as they head to Lucas Oil Field in Indianapolis. The Bucs are 5-0 at home.

6-0: The Colts’ record when they rush for at least 125 yards. They’re 0-5 when they don’t.

5: Number of times in 10 games this season that Buccaneers QB Brady has passed for 300 yards in a game.

157.7: Average rushing yards gained by Colts RB Jonathan Taylor over his past three games.

18-0: Tampa Bay’s record since the start of the 2020 season when leading a game at halftime. No other NFL team is unbeaten in this scenario over that span of time.

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Buccaneers vs Colts Moneyline

Going back to his New England days, Brady is 5-4 all-time against the Colts. This will be the sixth visit by the Buccaneers to Indianapolis. They are 1-4 there so far. Tampa Bay’s lone win in Indy was a 31-28 verdict in 1997. The Colts are 3-2 at home this season, while Tampa Bay is 2-3 on the road.

In NFL betting, Indianapolis is 0-2 straight up this season as a home underdog. The Buccaneers are 2-3 straight up as the road chalk. Oddly, Tampa Bay is also 0-3 SU in Sunday afternoon road games this season. Take the Colts at home at +145 at DraftKings.

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Buccaneers vs Colts Point Spread

Do the math. NFL betting apps are giving us a team (the Colts) that’s won five of six and you’re getting three points if you play them at home in this game. It sure seems like a no brainer.

On top of that, only Green Bay (nine), Dallas (eight) and Arizona (eight) have won more games this season against the spread than the Colts, who are 7-4. Tampa Bay is an ordinary 4-6 ATS. As an away favorite, the Buccaneers are 0-5 ATS. Indy is 1-1 ATS as a home underdog. The Colts are 5-0-1 ATS in their last six games against Tampa Bay. Take the three points and play Indy in NFL spreads wagering.

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Buccaneers vs Colts Totals

Odd scores and the Colts are going hand in hand this season. Along with the 41-15 win over Buffalo, Indy beat the New York Jets 45-30. Neither final score had ever been previously posted in an NFL game. Indianapolis has scored over 40 points in two of the past three games and over 30 points in five of the last six games.

The total for this game is set at 51.5 points by betting sites. The total has gone under in four of the last five and five of the past seven Buccaneers games. Still, this seems like a game where points will be scored in abundance. Play the over. You can get Over 51.5 at FanDuel.

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