Since these two teams met in Week 3, both squads have improved dramatically. Both the Titans and the Colts have won three of their last four games and each side is starting to look like a legitimate playoff contender. The Titans are certainly in a better position entering this matchup as they sit at 5-2 with the Week 3 win over the Colts.

However, the Colts have to be feeling good about themselves after an impressive win against the 49ers. If it weren’t for a late-game collapse against the Ravens, they would have won four straight with Carson Wentz playing outstanding football. Needless to say, both teams want this win. But the Colts desperately need it more to keep pace with the Titans in the division.

To get you ready for this AFC South matchup, here is everything you need to know from an NFL betting perspective going into Week 8.

Check out the latest Colts vs. Titans odds ahead of their matchup in Week 8.

Titans vs. Colts Key Matchups

Colts WR Michael Pittman vs. Titans CB Janoris Jenkins: Pittman has developed into a No. 1 receiver for the Colts. But do the Titans have the defensive backs to slow him down this week? Probably not, but Jenkins will likely be the one following him on Sunday.

Colts LG Quenton Nelson vs. Titans DT Jeffrey Simmons: Nelson returned from the injured reserve list in Week 7, but was called for holding twice. He will have his hands full once again with Simmons on Sunday.

Titans WR A.J. Brown vs. Colts CB Kenny Moore II: Brown has 15 receptions over the last two weeks and will have a significant size advantage over Moore on Sunday. Can the Colts limit him once again in this matchup?

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Titans vs. Colts Key Stats

34:08: The Titans lead the NFL in time of possession at 34:08 minutes per game.

21: The Colts have the No. 11 scoring defense in the NFL, allowing just over 21 points per game.

273.5: The Titans allow 273.5 passing yards per game, which is among the worst in the NFL.

5-1: The Titans are 5-1 ATS in their last six games.

14: The Colts have won 14 of their last 18 games against the Titans at home.

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Titans vs. Colts Player Props

Derrick Henry under 103.5 rushing yards

Odds: -115 at DraftKings

The Colts have done a good job of bottling up Henry in the past. Look for the Titans to try to establish the run, but to utilize the passing game on the road to move the ball.

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A.J. Brown over 68.5 yards

Odds: -115 at DraftKings

Brown has seen 15 targets over the last two games and is finally starting to look healthy. He has a significant size advantage over the defensive backs for the Colts and should be in for a big day on Sunday.

Mo Alie-Cox to score a touchdown

Odds: +250 at DraftKings

Alie-Cox is one of the biggest tight ends in the NFL and has a knack for finding the end zone. Don’t be surprised if he sees multiple end zone targets in this contest.

Titans vs. Colts Moneyline

The Titans won the first matchup between these two teams (25-16), but you can almost throw out that result as Carson Wentz was dealing with two badly sprained ankles. Since that game, he has thrown eight touchdowns to zero interceptions and has a passer rating of 119.5.

He’s played outstanding and it’s helped that Michael Pittman has developed into a star on offense. Both of these teams can run the ball really well and it will likely come down to which quarterback plays better.

With this game feeling like a bit of a coin flip, take the Colts at +100 on PointsBet to win this game. They are usually good at home and these odds are too juicy to pass up.

Titans vs. Colts Point Spread

In divisional games like this, you will usually see the home team favored by three points. That is especially true if both teams are of similar standing and caliber. However, that is not the case this week as the Titans are actually one-point favorites on the road.

It does make sense after the Titans just defeated the Bills and Chiefs in back-to-back games. They also have already beaten the Colts once this season and have one of the league’s most difficult offenses to stop. However, the Colts can be just as balanced as well, with Jonathan Taylor totaling 551 yards in the team’s previous four games.

Take the Colts +1 (-110) on DraftKings as a home underdog and expect them to get the win. However, be sure to track this line throughout the week as it could move on various betting apps and sportsbooks.

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Titans vs. Colts Totals

The goal for both of these teams is to use the running game to keep the defense off the field. Both Ryan Tannehill and Carson Wentz are at their best when they can utilize play-action and aren’t forced to throw the ball more than 35 times a game. The pace of this game is likely to be very slow and we could easily see another 25-16 type of game on Sunday.

Points are going to come at a premium and it would be a bit of a shock if either offense scored 30 or more points. For that reason, take the Under 51 points on FanDuel (-110) and expect a close, low-scoring game in Indianapolis.

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