Fresh off a solid 28-16 road win at the Indianapolis Colts, the Seattle Seahawks will play host to the Tennessee Titans in their 2021 NFL home opener. The Titans were whipped 38-13 by another NFC West team, the Arizona Cardinals, in their season opener.

Seattle has won 12 home openers in a row, including a 20-18 victory over the Titans in 2010. The Seahawks will be seeking to open 2-0 for the third successive season. Tennessee has won its past two road openers.

In NFL betting, Seattle opened as a 5-point favorite over Tennessee. Online sportsbooks set the total at 54 points.

RELATED: NFL Week 2 Odds & Betting Lines and be sure to check out more Seahawks vs. Titans odds.

Titans vs. Seahawks Key Matchups

Titans RB Derrick Henry vs Seahawks Run Defense: The Seahawks were the NFL’s No. 5 run defense last season, allowing 95.5 yards per game on the ground. In the opener they held Colts RB Jonathan Taylor to 56 yards on 17 carries. Henry, the NFL rushing leader the past two seasons, was limited to 3.4 yards per carry (17-for-58) in the opener against the Cardinals.

Tennessee OL vs Seattle Pass Rush: The Seahawks have recorded 2+ sacks in 11 straight games. That’s their longest streak since 2004-05. Arizona’s Chandler Jones collected five sacks against the Titans in the opener.

Titans Secondary vs Seahawks WRs: You might want to look into some Seattle WR player props at your favorite sports betting apps. Tyler Lockett and D.K Metcalf could have a field day in this one. Tennessee has allowed 31 red zone TD passes since 2020. That’s the most in the NFL.

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5 Key Titans vs. Seahawks Stats

3-for-29: All-Pro WR Julio Jones was supposed to bring Tennessee a step closer to the Super Bowl. Instead, he simply looked out of step against Arizona. Along with just three catches for 29 yards, he was also assessed a 15-yard penalty early in the game that halted a Titans drive.

65-2: Since 2012, that’s Seattle’s record when leading by at least four points at halftime.

89: Fourth quarter and OT TD passes thrown by Seattle’s Russell Wilson. That’s the most of any QB since Wilson entered the NFL in 2012.

1: Wins by the Titans franchise in Seattle since 1980, a span of eight games.

152.3: Wilson’s Week 1 passer rating. After getting carved up by Cardinals QB Kyler Murray, the equally elusive Wilson could cause fits for the Titans defense.

Titans vs. Seahawks Weather Forecast

Wait, what? It’s going to rain in Seattle? That can’t be right. The forecast is calling for rain, 3-mph wind and a game-time temperature of 54 degrees. Not only must the Titans deal with the 12th Man at the first capacity crowd at Lumen Field since 2019, they also get fed Seattle weather.

RELATED: NFL Week 2 Odds & Betting Lines For All 16 Matchups

Titans vs Seahawks Player Prop Bets

Titans RB Derrick Henry over 84.5 yards rushing ( -115 at DraftKings ): Henry was held to 58 yards by the Cardinals. Only once last season was he held under 60 yards on the ground. The next week, he went off for 212. He never posted consecutive games under 100 yards.

Seahawks RB Chris Carson over 15.5 carries ( -115 at BetMGM ): Carson carried 16 times with Rashaad Penny available last week. Penny is out this week.

Seahawks Jason Myers to kick longest field goal ( -120 at bet365 : Tennessee is already playing musical kickers, cutting Marvin Badgley for Randy Bullock. Seattle’s Myers is one of the most reliable placement specialists in the game.

Seahawks QB Russell Wilson over 2.5 TD passes (+155 at TwinSpires): Wilson threw for four TDs last week against the Colts. Arizona’s Kyler Murray threw for four TDs against the Titans.

Henry over 1.5 receptions ( -120 at DraftKings ): Henry has caught three passes in each of Tennessee’s past two games. The Titans appear to be looking to get him the ball more as a receiver.

Titans vs. Seahawks Moneyline

Straight up, Seattle is 7-2 all-time at home against the Tennessee franchise. That includes games against the Houston Oilers. NFL betting sites are anticipating that streak continuing. The Seahawks are listed as a healthy -255 betting choice in this game.

Tennessee was an impressive 6-2 SU on the road last season. Only three teams won more away games than the Titans last season and two of them – Kansas City and Tampa Bay – played in the Super Bowl. That being said, Seattle should win this game. But a -255 moneyline simply isn’t worth the risk.

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Titans vs Seahawks Point Spread

The NFL spreads are mostly calling the Seahawks as 5-point home favorites. However, the Titans are 6-3-1 against the spread in 10 games following a double-digit loss under current head coach Mike Vrabel.

Outright, they are 8-2 in those games, including a current streak of eight successive victories. That being said, the Titans are 0-4 ATS in their last four games. However, Tennessee is also 5-1 ATS in the last six against the Seahawks.

Seattle is 5-0 ATS in the club’s last five September games but just 1-5 ATS in the last six games against a team with a losing record. Take the Titans and the points. You can get Titans at +5.5 at BetMGM Sportsbook .

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Titans vs. Seahawks Totals

The total is between 53.5 and 54 points on this game. The under is 8-2 in Seattle’s last 10 games. Tennessee tied for the NFL lead last season, going over 12 times. The Titans were 12-4-1 against the total overall in 2020. In six of Tennessee’s last seven road games, the over has proven to be the winning play.

The Titans will want to, pardon the pun, tighten up following last week’s debacle. The total has gone under in six of the past eight Seahawks-Titans games. Take the under 54 points on offer at DraftKings .

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