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Kentucky Derby 2022 Odds, Best Bets & Predictions

Adam Thompson for Bookies.com

Adam Thompson  | 5 mins

Kentucky Derby 2022 Odds, Best Bets & Predictions

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Our Bookies.com handicapper Adam Thompson crushed horse racing in 2021. If you had bet $5 on the picks for the 2021 TVG Pacific Classic, your account would be $232 fatter today. That’s just the latest in a string of horse racing betting successes for Thompson, who won $480 on a $10 wager at the 2021 Preakness Stakes and hit the exacta at the Belmont Stakes, taking $75 on a $10 bet.

Now our top horse racing handicapper turns his sights on the 2022 Kentucky Derby. The 20-horse field goes to post at 6:57 p.m. Last year Thompson picked Mandaloun – the eventual winner after Bob Baffert’s Medina Spirit was disqualified – and hit the Derby-Oaks double. 

Kentucky Derby 2022 Odds

1|Mo DonegalIrad Ortiz Todd Pletcher 10-1
2|Happy Jack Rafael Bejarano Doug O’Neill 30-1
3|Epicenter Joel Rosario Steve Asmussen 7-2
4|Summer Is Tomorrow Mickael Barzalona Bhupat Seemar 30-1
5|Smile Happy Corey Lanerie Ken McPeek 20-1
6|Messier John Velazquez Tim Yakteen 8-1
7|Crown Pride Christophe Lemaire Koichi Shintani 20-1
8|Charge It Luis Saez Todd Pletcher 20-1
9|Tiz the Bomb Brian Hernandez Ken McPeek 30-1
10|Zandon Flavien Prat Chad Brown 3-1
11|Pioneer of Medina Joe Bravo Todd Pletcher 30-1
12|Taiba Mike Smith Tim Yakteen 12-1
13|Simplification Jose Ortiz Antonio Sano 20-1
14|Barber Road Reylu Gutierrez John Ortiz 30-1
15|White Abarrio Tyler Gaffalione Saffie Joseph Jr.10-1
16|Cyberknife Florent Geroux Brad Cox 20-1
17|Classic Causeway Julien Leparoux Brian Lynch 30-1
18|Tawny Point Ricardo Santana Brad Cox 30-1
19|Zozos Manuel Franco Brad Cox 20-1
20|Ethereal Road Luis Contreras D. Wayne Lukas 30-1

These Kentucky Derby morning-line odds were set by Churchill Downs and accurate as of publication. 

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2022 Kentucky Derby Favorites at Churchill Downs

It doesn’t get any bigger than the Run for the Roses. The horse racing odds at most top sportsbooks for the weekend’s Kentucky Derby have three horses near the top of their boards, including the morning-line odds at TwinSpires, among other sports betting apps.

Zandon (#10, 3-1 morning line odds) 

The early favorite, showing explosiveness at the end that has made him a podium finisher in all four career races. Chad Brown’s entry won the Grade 1 Blue Grass Stakes in dominating fashion. 

Epicenter (#3, 7-2)

Has won four of six career races and gives a great chance to win the Derby for trainer Steve Asmussen, who has the most wins in history but zero in this race. He beat Zandon straight-up in February at the G2 Risen Star Stakes and another sleeper, Zozos, at the G2 Louisiana Derby. 

RELATED:  Kentucky Derby 2022: Chasing The Perfect Mint Julep

Messier (#6, 8-1) 

A Bob Baffert horse before he was moved to another trainer due to Baffert’s suspension. This is still a Baffert horse. Messier has taken first or second in six career races but has never run in a field bigger than six horses. What happens when he gets into the traffic of this mammoth 20-horse field? 

2022 Kentucky Derby Predictions

My favorite is Epicenter. This is it for Asmussen and he’s beaten the best in some of the top Derby tuneups. Zandon should be there in the end, with Mo Donegal (#1, 10-1), the Todd Pletcher-trained entrant, a challenger, and our favorite double-digit odds contender. We’re topping all bets with those three. 

Messier, along with White Aparrio (#15, 10-1) and White Happy (#5, 20-1), are worth tossing in key spots. 

2022 Kentucky Derby Best Bets

Here’s how we’re betting the race; you can lay out your bet at TwinSpires racing book and on their sports betting app:

  • $20 To Win: 3
  • $5 Exacta Box: 1,3,10
  • $.50 Trifecta: 1,3,10 with 1,3,5,6,7,8,10,15
  • $.10 Superfecta: 1,3,10 with 1,3,6,10,15 with 1,3,5,6,7,8,10,15 with 1,3,5,6,7,8,10,15

Kentucky Oaks, Friday

  • $5 Exacta Box: 4,7,10
  • $.50 Trifecta: 1,3,10 with 1,3,5,6,7,8,10,15 with 1,3,5,6,7,8,10,15

Oaks-Derby Double

  • 4,7,10 with 1,3,10

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About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been established as one of the nation's premier handicappers, specializing in the NFL where he's hit on more than 60% over the past three years. Adam's NBA, PGA and horse racing picks have also produced major winners over the last 12 months. His customized NFL and NBA odds for players and teams have been picked up by hundreds of websites over the past year.