Week 11 of the NFL betting season offers a sneak peek at a potential AFC championship game matchup and a possible winner-take-all NFC East showdown. It has a huge act to follow from Week 10. 

The 2-time defending Super Bowl champion Kansas City Chiefs are 10-0. They face their toughest test since opening night with a late Sunday afternoon kickoff at Buffalo. Oddsmakers have the Bills as 2.5-point favorites. Patrick Mahomes just keeps winning. Meanwhile, Josh Allen and the Bills have all-but officially wrapped up the AFC East.

RELATED: Super Bowl 59 Odds

The National Game of The Week on CBS kicks off at 4:25 p.m. 

Underdogs went 8-1 in the first 9 games of Week 10 and finished 11-3 heading into Monday night. 

The week begins with the most compelling Thursday night game of the season thus far when the Commanders visit NFC East-rival Philadelphia. The Linc will be lit for this 8:15 p.m. kickoff. The big question is this: Will Al Michaels take the points? 

Four teams are on the bye: New York Giants, Tampa Bay, Carolina, and Arizona.

2024 NFL Week 11 Picks

Now it’s on to our Week 11 NFL picks to back on your favorite sports betting app. 

RELATED: Register Now For Bookies Plus

2024 NFL Week 11 Best Bets 

Thursday, November 14
Washington Commanders at Philadelphia Eagles, 8:15 p.m. (Amazon Prime)

Buzz: The Battle for Supremacy in the NFC East offers up the most-compelling Thursday night matchup of the season. These teams are a combined 14-3-1 ATS. The Eagles (7-2) hold a one-game lead in the loss column over Washington (7-3). Philly stampeded Dallas Sunday. Commanders fell late to Pittsburgh. They have lost 7 straight after a loss and have a short week and have to go on the road to the Linc. And they're just 1-6 ATS against teams with a winning record. A Philly win means the NFC East will be theirs to lose. The total here seems out of line given the strength of both defenses against the pass and the fact that both teams are in the top third of the league in terms of points allowed. Take the points here, but not if this one edges above 3 points. The Eagles have a 57.1% chance to win, according to ESPN Analytics. 

Best Bet: Eagles -3 (-110) DraftKings

Sunday, November 17
Jacksonville Jaguars at Detroit Lions, 1 p.m. (CBS)

Buzz: The Jaguars may ride into the Motor City with Mac Jones at QB. The Lions pulled off a comeback for the ages Sunday night. They overcame 5 picks thrown by Jared Goff and scored the final 19 points in their 26-23 win at Houston. But guess what. Jacksonville (+7.5) covered Sunday at home against Minnesota. And the Lions (-3.5) did not. The Lions have covered in 9 of 11 games. And they are 43-19 ATS under Dan Campbell. The Jaguars are winless on the road this season and could be overwhelmed quickly. This number expanded from 10 to 13 Sunday night. This is their biggest number of the season. They covered as 12.5-point favorites at Tennessee with ease, 52-14. The Jaguars might not crack double digits. The Lions have a 76% chance to win, according to ESPN Analytics. 

Best Bet: Lions -13 DraftKings

Sunday, November 17
Baltimore Ravens at Pittsburgh Steelers, 1 p.m. (CBS)

Buzz: Another AFC North Classic. The Ravens and Steelers are locked atop of the division. Pittsburgh has overperformed this season, going 7-2 SU and ATS to start the season. But their schedule hasn’t been among the toughest. The Ravens have already played Buffalo and Kansas City (losing to them both). The Ravens lead the NFL in scoring, rushing yards, and are third in passing yards. The Steelers have a top-4 rushing and scoring defense. But showed cracks against rookie Jayden Daniels Sunday. Lamar Jackson will be looking to go long and deep on the run. The Ravens, meanwhile, rank 32^nd against the pass and got shredded by the Bengals in a 35-34 win on Thursday. Lucky here they’re up against Russell Wilson. The Steelers and Ravens are a combined 12-6-1 ATS. Pittsburgh has beaten Baltimore 5 straight times as an underdog. Something’s gotta give. The Ravens have a 60.6% chance to win, according to ESPN Analytics. 

Best Bet: Ravens -3 DraftKings

Sunday, November 17
LA Rams at New England Patriots, 1 p.m. (FOX)

Buzz: The restored and rejuvenated Rams come to Foxboro off a Monday night game against the Dolphins. They won 4 straight before that game. The Patriots (3-7, 4-5-1 ATS) need to keep their opponents under 20 for them to have a shot at winning. They did Sunday, in a dominating 19-3 win over the Bears. The Rams could put up that much in the first half. Or not. This is an early-afternoon East Coast game after a Monday nighters. Drake Maye is reason enough to watch for Patriots’ fans. But they won’t be touching this game with their mother-in-law’s money. The Rams have a 67.4% chance to win, according to ESPN Analytics.

Best Bet: Patriots +5.5 DraftKings

Sunday, November 17
Indianapolis Colts at New York Jets, 1 p.m. (CBS)

Buzz: The Colts have underwhelmed on the field. But they’ve dominated against the spread. Indy covered in 7 of its first 10 games, despite going only 4-6 straight-up. But their discount has evaporated. And their struggles have worsened. Indy has lost 3 straight after falling to Buffalo. But no team in the NFL brings more dysfunction and disappointment to the field than the Jets. New York's defense was exposed in a 31-6 baby-seal clubbing at Arizona Sunday. Aaron Rodgers is 40 going on 60. If you must bet on this train wreck, take the under and look away. But take the over on the number of Jets fans at MetLife shown on TV with bags over their heads at 6.5. The Jets have a 58.2% chance to win, somehow, according to ESPN Analytics.

Best Bet: Under 44 Points DraftKings

Sunday, November 17
Las Vegas Raiders at Miami Dolphins, 1 p.m. (FOX)

Buzz: The Dolphins defense disappointed in back-to-back, last-play-of-the-game losses in Weeks 8 and 9. Miami lost both games despite scoring 27 points in each. Miami will be coming off a Monday night game at SoFi against the Rams before heading home. The Raiders can make any offense look good these days and have lost 5 straight. But they are coming off the bye. So the issue of playing an early-Sunday afternoon, outdoor, East Coast game, in the warm climes of South Florida might be slightly mitigated. The Dolphins have failed to cover in 4 of 5 games as favorites. This is their biggest number of the year on that end. 

Best Bet: Raiders +7 (-110) DraftKings

Sunday, November 17
Minnesota Vikings at Tennessee Titans, 1 p.m. (CBS)

Buzz: The Vikings were the darling of the NFL and NFL bettors through the first 5 games of the season. Then Sam Darnold remembered he once played for the Jets and balance was restored to the universe. Minnesota’s lone cover in the past month has been as 6-point favorite over Indy. The Vikings whiffed badly on the line (-7.5) in their 12-7 win at Jacksonville Sunday. The Titans, meanwhile, are an NFL worst 1-8 on the line. They have the best pass defense in the NFL but only forced three 3-and-outs in a 27-17 loss to the Chargers Sunday. 

Best Bet: Titans +6.5 DraftKings

Sunday, November 17
Cleveland Browns at New Orleans Saints, 1 p.m. (FOX)

Buzz: Browns QB Jameis Winston returns to the Crescent City as the opposing QB. Winston took over for the injured Deshaun Watson. The 2-7 Browns have covered 10 straight times as underdogs against NFC teams. And Jameis will be focused and ready for this “homecoming.” Derek Carr is back in the driver’s seat for the 3-7 Saints. That didn’t help former coach Dennis Allen, who was fired last week. Carr and the Saints stunned the NFC South leading Falcons Sunday in a gutsy 20-17 win for interim coach Darren Rizzi. Can they sustain that emotion for another week? We'll see. 

Best Bet: Browns +2.5 (-110) DraftKings

Sunday, November 17
Seattle Seahawks at San Francisco 49ers, 4:05 p.m. (FOX)

Buzz: The 49ers (5-4) beat the Seahawks 36-24 in Seattle in Week 7. They scored an easy cover as 3.5-point favorites. The Seahawks (4-5) are coming off the bye. Seattle has helped keep the nation’s sportsbooks in the black season, going just 2-7 ATS. They’ve covered just once since Week 3. The 49ers have lost Brandon Aiyuk for the season but got Christian McCaffrey back in time against Tampa Bay. They needed CMC to escape Raymond James with a 23-20 win at the gun.. San Francisco's defense stabilized in Week 10. But those missed kicks. Yikes. McCaffrey’s presence is key here. Brock Purdy impressed none other than Tom Brady on Sunday - but it wasn't for his arm. The Niners have failed cover in their last 8 tries after a win. This number is too much for an intradivisional foe. 

Best Bet: Seattle +6.5 (-110) DraftKings

Sunday, November 17
Atlanta Falcons at Denver Broncos, 4:05 p.m. (FOX)

Buzz: The arrival of Kirk Cousins proved to be the missing ingredient for the Falcons this season. But they got caught in a new-coach trap against New Orleans Sunday. The Falcons will be playing on the road, outdoors, and at altitude. The Broncos’ defense rebounded Sunday. But the Chiefs are still the Chiefs and blocked a potential game-winning FG try leaving Denver emotionally stunted in a 16-14 loss. Denver, however, is 7-3 ATS. And the Falcons have both lost and failed to cover in 5 straight against the AFC. 

Best Bet: Broncos ML (-124) DraftKings

Sunday, November 17
Kansas City at Buffalo, 4:25 p.m. (CBS)

Buzz: The “Game of the Year” highlights the Week 11 schedule. Jim Nantz and Tony Romo will add to this AFC Championship Game preview feel. The Chiefs and Patrick Mahomes just do whatever it takes to win. In their 10-0 start, 8 of those wins came by 1 score or less. Sunday's 16-14 win over Denver wasn't clinched until KC blocked a last-second, 35-yard field goal try. The Chiefs are winning in all three phases: Mahomes, Defense, and Special Teams. They haven't lost since Christmas. If they're going to lose one game in the regular season, this one will be it. The key match-up is Steve Spagnuolo’s defense vs. Josh Allen. Kansas City has covered at Buffalo 4 straight times. Wait a minute . . . Mahomes is 13-1-1 ATS when getting points as a betting underdog, including his Super Bowl 58 win and KC's outright 28-20 Week 7, both over San Francisco. His one loss ATS as an underdog? To the Bills. Not enough. 

Best Bet: Chiefs +2.5 (-110) DraftKings

Sunday, November 17
Cincinnati Bengals at Los Angeles Chargers, 8:20 p.m. (NBC)

Buzz: The Bengals fell short against the Ravens Thursday, losing 35-34 after a missed 2-point conversion. The Bengals tore up Baltimore’s worst-in-the-NFL defense, but it wasn’t enough. Ja’Marr Chase caught 11 balls for 264 yards and 3 TDs from Joe Burrow. Cincy will enjoy the mini-bye to recover emotionally from Thursday’s loss. The Bengals won’t have to worry about Lamar Jackson this time. The Bengals have covered 5 straight times on the road. 

Best Bet: Bengals +1.5 (-110) DraftKings

Monday, November 18
Houston Texans at Dallas Cowboys, 8:15 p.m. (ESPN)

Buzz: Don’t mess with Texas. But this one Texas-sized mess. Especially in Dallas. The Cowboys are struggling with everything. Now, Dak Prescott is gone for the duration. Cooper Rush was so bad against the Eagles, he was benched for Trey Lance. Jerry Jones has turned off Mike McCarthy's hot seat for the rest of the season. Still, Micah Parsons but McCarthy on blast after their 34-6 loss to Philly at home. The Cowboys smell all the way to Fort Worth, but at least they’ll be able to use Dak’s absence as an excuse. Things really can’t get any worse in Big D. The Texans gave up the last 19 points in a 26-23 loss to the Lions at home. They're struggling with some missing pieces. But the Cowboys have become the best get-right opportunity in the NFL. And Houston learned the hard way Sunday - like every other team in the NFL but Detroit - not to rely on kickers for anything. And the Texans defense won't wilt in the 2nd half against Rush or Lance. 

Best Bet: Texans -7 (-110) DraftKings