It’s a clash of two of the last three quarterbacks to be chosen first overall in the NFL Draft, as Kyler Murray (2019) and the 2-0 Arizona Cardinals travel to Jacksonville to face Trevor Lawrence (2021) and the 0-2 Jaguars.

The Cardinals are 7.5-point road favorites at betting sites in this game. Arizona also opened 2-0 last season and lost in Week 3 to the winless Detroit Lions. Let’s take a deep dive into Cardinals vs Jaguars odds.

RELATED: NFL Week 3 Odds & Betting Lines For All 16 Games

Cardinals vs Jaguars Key Matchups

Trevor Lawrence vs Cardinals pass rush: Lawrence isn’t in Clemson any longer. In his effort to learn the NFL game, he’s getting schooled. The Arizona defensive front terrorizes QBs. Quarterbacks selected first overall are a combined 13-33-2 as rookies over the past six seasons.

Kyler Murray vs Jaguars defense: Murray is letting his arm do the work so far this season. He’s passed for 684 yards, second among NFL QBs. Jacksonville has allowed 12 players to go for 100+ yards in receiving over the last 14 games.

Marvin Jones vs Arizona secondary: Jaguars WR Marvin Jones is quietly one of the most efficient pass catchers in the NFL. He’s caught TD passes in both of Jacksonville’s games. Jones is the only NFL WR with at least nine TD receptions in each of the past two seasons.

5 Key Cardinals vs Jaguars Stats

7: TD Passes for Murray this season. That’s second among NFL QBs and tied for the most among Cardinals QBs through the first two games of the season since 1970.

5: INTs by Lawrence this season. That’s tied for first in the NFL.

17: Losses in a row by the Jaguars. One more setback and they’ll hold the second-longest losing streak in NFL history.

62: Yards of Matt Prater’s second-quarter field goal last week. It was his NFL record 60th FG of 50+ yards.

3 TD catches: By DeAndre Hopkins. He’s the first Cardinals WR with that many TD receptions through the first two games since Larry Fitzgerald in 2016.

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Cardinals vs. Jaguars Player Props To Back

Jaguars WR Marvin Jones, Anytime TD Scorer

Odds: +155 at FanDuel

Jones has scored a TD in both of Jacksonville’s games this season.

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Cardinals RB Chase Edmonds, Over 3.5 Receptions

Odds: -115 at DraftKings

Edmonds has gone over this total in both games so far this season.

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Jaguars QB Trevor Lawrence, Over 0.5 INT

Odds: -227 at BetMGM

The top pick in the 2021 draft has thrown four picks through two games.

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Cardinals vs Jaguars Weather Forecast

Sunday’s weather report for Nissan Stadium is calling for clear skies, 2 mph wind and a game-time temperature of 77 degrees. The Cardinals were 2-2 straight-up last season in games played at 1 p.m. ET at an East Coast venue.

Cardinals vs Jaguars Moneyline

Going to betting apps and wagering on a team straight-up to lose that’s done so in 17 straight games sure seems like a lock. No matter how you slice it, the Jaguars are a bad bunch of football players.

They are 0-11 SU over their last eight home games. Jacksonville is 0-11 SU in the last 11 meetings with NFC teams. The Jaguars have lost their last 15 in a row as a moneyline underdog and their last three in succession as a moneyline favorite. Still, unless you’re planning to package it in a parlay, there’s no reason when NFL betting to be playing Arizona as a -360 chalk. If you are new to wagering at Arizona sports betting sites, consider your home team in parlays.

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Cardinals vs Jaguars Point Spread

This line has moved significantly in the NFL odds after opening at Arizona -6. On the surface, laying more than a touchdown on an NFL road team seems like a big ask when making NFL picks. Except we’re talking about the Jaguars here.

They’ve lost six games in a row by at least 10 points. In 11 games during their 17-game losing skid the Jags have gone down to a double-digit defeat. The average margin of defeat in Jacksonville’s 17 losses is 13 points. Jacksonville is one of five NFL teams this season that is 0-2 against the spread. Take Arizona and lay the points at DraftKings.

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Cardinals vs Jaguars Totals

Jacksonville has been outscored 60-34 this season. Arizona has put 72 points up on the scoreboard through two games. The Cards gave up 33 last week to Minnesota. That being said, six of the last nine Cardinals games and five of Arizona’s last six games played in September have gone under. The under has also been a winning play in seven straight Arizona road games.

Then again, four of the past five Arizona-Jacksonville games went over, as have eight of the last eight Jaguars games when an NFC club provided the opposition. The total of 51.5 points set by sportsbooks on this game isn’t outrageous. The Over is the play at TwinSpires.