It’s a Week 7 make-or-break matchup on Thursday Night Football, as Kyler Murray and the Arizona Cardinals host Andy Dalton and the New Orleans Saints. 

Both the Cardinals and the Saints enter the game at 2-4; a loss will make it quite difficult to climb into a balanced and competitive NFC Playoff chase. A win, at the least, offers a wild card tiebreaker. 

Arizona is favored on NFL betting sites by only 1.5 points in the latest Saints vs. Cardinals odds, with an Over/Under set at 45.5 points on betting apps. The home team has covered the spread in seven of the last eight meetings between these teams. 

Bookies.com NFL handicapper Adam Thompson – who has hit on over 60% of his NFL best bets the last three years running – reveals his plays for the critical NFC matchup. 

Saints vs. Cardinals Point Spread Pick

Arizona has played poorly at home, averaging only 16.7 ppg while allowing 28.0. It’s failed to cover in seven of its last eight home games. And yet, New Orleans is one of only three teams that hasn’t covered a game on the road. So which underachieving side is the better bet? 

Statistically, it’s a wash. That makes one believe the home team is the best side. Arizona hasn’t shown up at home, but New Orleans hasn’t had a road game since Week 3. 

The Saints’ injury issues on offense have become worrisome. We side with the Cardinals laying the small number, but not wholeheartedly. 

$1,000 First Bet on Caesars Promo Code: BOOKIES1000

Tap for Promo Activated! Visit site

Used 10 Times Today

Must be 21+ to participate. T&Cs apply.

Saints vs. Cardinals Over/Under Best Bet

Primetime games have produced very little scoring. The Under is hitting on well over 70% of all night games. It’s also performing quite well when the underachieving Cardinals offense is involved, hitting in four in a row. 

Arizona averages 16.7 ppg at home. The Saints might be without all three starting receivers and James Winston. This is a high total for one team that sputters and another that has limited weapons. Take the Under for yet another Thursday night. 

Related: NFL Week 7 Picks, Best Bets, and Predictions

Saints vs. Cardinals Moneyline Pick

We’re backing Arizona but recognize the issues. The Cardinals lose Marquise Brown but gain DeAndre Hopkins. Statistically, the offense has been average, the defense better – and better than the Saints, who have allowed 28-32 points in their last three games. 

New Orleans has lost four of five. Andy Dalton historically has played noticeably worse on the road, and the injuries continue to be a concern. 

It’s do-or-die for Arizona coach Kliff Kingsbury, and it’s time for Murray to be the player everyone thinks he should be. This is a prime spot for it. Arizona at -120 on the moneyline is the play. 

Best Saints vs. Cardinals Player Props

Andy Dalton, Under 216.5 Pass Yards

Odds: -110 at DraftKings

Michael Thomas is out, Jarvis Landry is out and at least one starting O-lineman is out. Andy Dalton doesn’t have a lot of downfield options here. He’s thrown for 187 and 162 yards the last two games, the former of which was against the horrid Seahawks defense. Arizona, for all its issues, has allowed 180, 218 and 160 pass yards the last three weeks, the last two vs. the Eagles and Seahawks. 

Bet $5, Get $150 Instantly

Tap for Promo Activated! Visit site

Used 72 Times Today

21+ and present in most states. (18+ DC/KY/NH/WY). Void in IA/KS/KY/LA/MD/MI/NJ/NY/TN/VA/VT/ONT. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. Min. $5 deposit. Min. $5 bet. Max. $150 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: dkng.co/bball. Ends 1/5/25 at 11:59 PM ET. Sponsored by DraftKings. GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD).

Kyler Murray, Over 282.5 Total Yards

Odds: -110 at BetMGM

In six games, Murray has finished with games of 232 and 233 yards, but the other four he far eclipsed this number and averaged 310.3 yards. He’s coming off a 100-yard rushing game, finally breaking out with his feet. Can he keep it going here? 

The return of DeAndre Hopkins helps. New Orleans allows about 222 ypg to QBs overall, but after giving up 183.7 pass yards per game the first three weeks, the number in the last three has ballooned to 260.3 ypg. 

Up to $1,500 in Bonus Bets if Your First Bet Loses Promo Code: BOOKIES

Tap for Promo Activated! Visit site

Used 67 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate & present in OH. In partnership with MGM Northfield Park. Gambling problem? Call 1-800-GAMBLER. Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.