Week 12 of the NFL betting season begins on Thanksgiving Day. The weekend schedule offers plenty of tasty leftovers for bettors and fans alike. Save us a drumstick, some stuffing and gravy. 

On Sunday, there are seven games in the 1 p.m. ET slot. The most intriguing matchup of the early afternoon features a rematch of last season’s AFC Divisional Round playoff game between the Bengals and Titans. The defending AFC champion Bengals are 6-4 and one game behind Baltimore in the AFC North. They have performed better at 7-3 against the line, including a win and cover over Pittsburgh Sunday. 

The Titans are among four teams in the AFC that are 7-3 outright, a game behind the 8-2 Chiefs. 

In last season’s playoff game, the Titans held the top seed in the AFC and the bye. But the day was disastrous for Mike Vrabel and Ryan Tannehill. The Bengals spent half the game in the Titans backfield and the other half picking off Tannehill. Or so it seemed. The Bengals used that game to convince the rest of the league that they were the real deal. The Titans were left to wonder what happened.

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It took several weeks this season for Vrabel to get his team back into winning mode. The Titans spent much of October and early November quietly running away with the AFC South. Not only are the Titans three games ahead of the Colts and Coach of the Year Jeff Saturday in the loss column, they also hold the tiebreaker due to a season sweep. 

The late-day Sunday schedule has the defending Super Bowl champs (in name only) Rams facing the Chiefs at Arrowhead. 

The Eagles play host to the Packers and whatever mood Aaron Rodgers finds himself in Sunday night. The Monday night game has Pittsburgh facing the Colts. When the schedule was announced, this game was one to watch. Now, it’s just another stale piece of pumpkin pie. 

Now it’s on to our post-Thanksgiving Day Week 12 NFL picks to back on your sports betting app: 

NFL 2022 Week 12 Picks 

Oddsmakers on betting apps have set betting lines on Week 12. Here are our picks and best bets: 

2022 NFL Week 12 Best Bets To Back Today

Denver Broncos at Carolina Panthers, 1 p.m. (FOX)

Good teams win. Great teams cover. Terrible teams lose three overtime games in 10 starts and have six losses by a combined total of 18 points. That’s the tale of the Denver Broncos. QB Russell Wilson is a punch line. The Panthers are just punch drunk. The total on this game slid from 37.5 to 35 points Sunday night. This is a triple-dog-dare if ever we've seen one.  

Best Bet: Over 35 Points (-110) with Caesars Sportsbook

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Houston Texans at Miami Dolphins, 1 p.m. (CBS)

By now, the Texans appear to be fully committed to making a run at the No. 1 overall pick. The Dolphins are far too good to stop them from achieving that goal, especially coming off the bye. How good are the Dolphins? They held possession of first place in the AFC East (due to their win over Buffalo in Week 3) without playing. This is one of three double-digit lines for the week. The gap between quality teams and also-rans will only widen from here. This widened by a point Sunday night. 

Best Bet: Dolphins -11.5 (-110) with Caesars Sportsbook

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Chicago Bears at New York Jets, 1 p.m. (FOX)

Green averaged 2.7 inches per play on offense in the second half in Sunday’s Most Jets Ever Loss at New England. This mess was still tied 3-3 with 26 seconds to play before the Jets opted to punt the ball to Marcus Jones instead of the ball boy on the sidelines. Jones' TD sealed the loss with five seconds to play. The Bears, too, lost on Sunday in terrible fashion at Atlanta. 

Joe Flacco has more TD passes this season than Zach Wilson and hasn’t played in 2 months. A Justin Fields win over Wilson will trigger Gang Green Nation, reminding them of the talent the Jets whiffed on taking when they chose the Boy QB with the No. 2 overall pick in 2021. 

Best Bet: Bears +6 (-110) with DraftKings Sportsbook

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Cincinnati Bengals at Tennessee Titans, 1 p.m. (CBS)

The Bengals and Titans met in the Divisional Round of the playoffs last year. The Titans held the No. 1 seed in the AFC and were coming off a first-round bye. The Bengals scored an upset win on the road thanks to a ferocious defense and relentless running attack. Both teams faltered earlier in the season but have rebounded well in the past month. 

Expect both to be back in the playoffs this season. The defending AFC champion Bengals are 6-4 and one game behind Baltimore in the AFC North. They have performed slightly better at 7-3 against the line, including a win and solid cover over Pittsburgh Sunday. The line has moved in Cincy’s favor here, as well.

Best Bet: Bengals -1 (-110) with DraftKings Sportsbook

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Tampa Bay Buccaneers at Cleveland Browns, 1 p.m. (FOX)

The Browns have one more week before QB Deshaun Watson is eligible. This could be their last game coached by Kevin Stefanski and started by QB Jacoby Brissett. Tampa Bay had the worst record in the NFL against the spread before its win in Germany over Seattle two weeks ago. But the Buccaneers are coming off a bye. They are getting healthy on both sides of the ball. Tom Brady is undefeated since his divorce. And TB 12 is No. 4 in the NFL in passing - after his bye week. 

Best Bet: Buccaneers -3 (-110) with DraftKings Sportsbook

Atlanta Falcons at Washington Commanders, 1 p.m. (FOX)

Both teams are in the playoff chase, with the Falcons just one game behind Tampa Bay in the loss column in the NFC South. The Falcons have rewarded their backers going 7-4 ATS despite a 5-6 record outright. The Commanders are a surprising 6-5 overall but have gone 5-0-1 ATS in their last six games. Oddsmakers might be moving this line even further. Take it early. 

Best Bet: Commanders -3.5 (-110) with DraftKings Sportsbook

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Baltimore Ravens at Jacksonville Jaguars, 1 p.m. (CBS)

The Ravens are among a flock of four teams just a game behind Kansas City in the chase for the No. 1 seed in the AFC. Lamar Jackson is a real threat in the conference to Patrick Mahomes II when it comes to MVP honors, if not in-game theatrics. The Jaguars remain in NFL purgatory until they move to London. 

Best Bet: Ravens -4 (-110) with DraftKings Sportsbook

LA Chargers at Arizona Cardinals, 4:05 p.m. (CBS)

The Chargers and Cardinals remain the NFL’s most frustrating underachievers. The Chargers are Charlie Brown. The Chiefs (and the playoffs) are Lucy and her football. The Cardinals, meanwhile, are an amorphous noise, like every adult in every Charlie Brown cartoon ever. Kliff Kingsbury’s team continues to impress on “Hard Knocks,” but not on the field. Kyler Murray/Colt McCoy and Justin Herbert will be padding the stats in this defense-less affair.

Best Bet: Over 47.5 Points with DraftKings Sportsbook

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Las Vegas Raiders at Seattle Seahawks, 4:05 p.m. (CBS)

Josh McDaniels is the Michael Scott of the NFL. Just when you think Dunder Mifflin is going to close the Scranton branch, the Broncos show up on the schedule and forget to cover Davante Adams in overtime. But next week, Scott's Tots miss out on their college scholarships. 

Best Bet: Seahawks -3.5 (-110) with FanDuel Sportsbook

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LA Rams at Kansas City Chiefs, 4:25 p.m. (FOX)

Two championship franchises but only one winner. Both have gone all-in to win championships in recent years. The Chiefs have cycled through a series of stars and hold the best record in the AFC at 8-2. The Rams have seen their horns fall off in the 10 months since winning Super Bowl 56. They are experiencing one monstrous Super Bowl hangover. 

The Rams are last in the league at 2-7-1 ATS and were down to their third-string QB in Week 11. The Chiefs are a mere 4-6 ATS. This line has ballooned from 11 to 14 points. The Chiefs could win this by 30 if they choose to do so. Kansas sports betting is now legal. Please wager responsibly. 

Best Bet: Chiefs -14 (-110) with Caesars Sportsbook

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New Orleans Saints at San Francisco 49ers, 4:25 p.m. (FOX)

Saints QB Andy Dalton played like it was 2012 on Sunday. The Saints at their best could win this one outright. The 49ers, however, are coming off the bye and should be healthy and ready for a win, but not a cover. 

Best Bet: Saints +8 (-110) with DraftKings

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Green Bay Packers at Philadelphia Eagles, 8:20 p.m. (NBC)

Too bad the NBC Peacock can’t flex its way out of this leftover turkey. One sure bet: Aaron Rodgers will pout. The Eagles are 9-1 outright. They rallied to win 17-16 at Indy on Sunday but fell to 5-5 ATS after failing to cover the 6.5-point line. The Eagles will have a well-lubricated Sunday night/holiday weekend crowd at their back. This one could get away from Green Bay early. 

Best Bet: Eagles -6.5 (-110) with Caesars Sportsbook

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Pittsburgh Steelers at Indianapolis Colts, 8:15 p.m. (ESPN)

Neither team has done particularly well playing on Sunday. Saturday is for the Colts. Monday night will belong to the Steelers. 

Best Bet: Steelers ML (+130) with Caesars Sportsbook