Giants vs Patriots Odds, Best Bets & SGP For MNF NFL Week 13

By Bookies.com Staff Dec 1st, 2025 8:26 AM EST

Drake Maye (10) (AP Photo/Vera Nieuwenhuis)

Two iconic franchises meet under the lights for Monday Night Football, as the New England Patriots travel to MetLife Stadium to face the New York Giants in a nationally televised matchup with long-term implications.

The Patriots (4–8) aim to rebound from a rocky season and showcase promising young talent on both sides of the ball. All eyes will be on quarterback Bailey Zappe, expected to start behind center, alongside emerging playmakers like Demario Douglas and Rhamondre Stevenson.

Meanwhile, the Giants (5–7) come in riding momentum after a gritty divisional win. With Tommy DeVito continuing to defy expectations and Saquon Barkley anchoring the ground game, Big Blue looks to keep pace in the NFC Wild Card race.

Bookies.com reveals the top NFL Odds for this Monday night showdown.

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Giants vs Patriots Betting Predictions

New England Patriots -4.5

Backing the Patriots -4.5 spotlights home-field advantage, where New England often tightens up defensively when leading late in games. Previous meetings saw New York covering large numbers, but adjustments by the Patriots staff prioritize minimizing second-half risk here in Foxborough this week—a trend reflected across similar matchups during December slates each season.

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Giants vs Patriots Same Game Parlay

1. Drake Maye Over 244.5

Drake Maye Over 244.5 passing yards stands out, given his steady performances above this threshold lately, regardless of opponent quality or weather factors at Gillette Stadium—key elements that typically suppress production elsewhere are less relevant here since he throws efficiently within structured play designs while sustaining drives throughout all four quarters.

2. TreVeyon Henderson Over 59.5:

TreVeyon Henderson Over rushing yards is supported by repeated instances where he surpasses posted lines behind solid blocking schemes—his ability to pick up chunk gains keeps him involved deep into close affairs; opposing linebackers have struggled corralling edge runs all fall, so the setup suits an active workload.

3. DeMario Douglas Over 16.5:

DeMario Douglas projects well over his receiving total based on increased target share paired with short-area route efficiency—the coaching staff has designed quick-release options benefiting Douglas particularly versus aggressive coverage units like New York's secondary; experience shows these tendencies translate into meaningful yardage even without massive catch volumes.