The seasons of the Arizona Cardinals and Detroit Lions can be summarized in their respective won-lost columns. At 10-3, no NFL team has won more games this season than Arizona. At 1-11-1, no NFL team has lost more games than the Lions.

Coming off a rare loss, the Cardinals arrive at Detroit’s Ford Field as 13.5-point road favorites in NFL betting. Apparently, top sportsbooks aren’t showing much confidence that the Lions can extend their home-field winning streak to two games.

Take a look at Cardinals vs Lions odds, injury report, betting lines and more.

Cardinals vs Lions Key Matchups

Cardinals Offense vs Lions Defense: The NFL’s No. 9 offense, Arizona can get it done on the ground (12th overall) or through the air (10th overall). Detroit’s defense just doesn’t get it done. The Lions rank 28th in the league.

COVID-19 Cripples Lions: The Lions have nine players in COVID-19 protocol. This list includes six defensive backs. They’ve been forced to activate seven players from their practice squad. That’s half of the squad.

Jared Goff vs Arizona: There hasn’t been a lot for Lions fans to get excited about with regards to their new QB but this game just might be it. Goff was 7-1 against the Cardinals in five seasons as QB of the Los Angeles Rams. Goff hasn’t lost to Arizona since 2016, his rookie season in the NFL.

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5 Key Cardinals vs Lions Stats

15: Touchdowns by Cardinals running back James Conner. He’s the second Cardinals RB to score that many TDs in a season in the past 50 years.

27: Years since the Lions won a division title. That’s the longest drought in the NFC.

2015: The last year in which the Cardinals beat Detroit. Arizona head coach Kliff Kingsbury is 0-1-1 against the Lions.

16.4: Points per game by the Lions this season. That’s the lowest total of any NFC team.

2: Giveaways by the Cardinals in road games this season. That’s the fewest of any NFL team.

Cardinals vs Lions Player Props

James Conner anytime TD

Odds: -220 at FanDuel

Conner has found the end zone 15 times this season.

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Jared Goff over 212.5 passing yards

Odds: -114 at FanDuel

Goff has gone over this total two weeks in a row.

Kyler Murray anytime TD and Arizona to win

Odds: +145 at PointsBet

Murray has three of his five rushing TDs this season against NFC North teams.

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Cardinals vs Lions Moneyline

The Lions are 3-1 straight up in their last four games against the Cardinals. However, Arizona has won two of the last three games played at Detroit. As Arizona sports betting fans know, the Cardinals are actually a significantly better road team than a home team this season. The Cardinals are just 3-3 at home but a perfect 7-0 on the road.

December hasn’t proven kind to the Cards, though. They are 5-10 SU in their last 15 games played in the last month of the year. Overall, the Lions are 1-15-1 SU in their last 17 games. At home, Detroit is 1-9 SU through the past 10 games. At -760, though, it’s a waste of time and money to place a wager on the Cardinals at the best NFL betting sites.

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Cardinals vs Lions Point Spread

When it comes to NFL spreads, these are two of the best teams in the league to play at top betting apps. The Cardinals are 9-4 against the spread. Surprisingly, the Lions are 8-5 ATS.

The Lions are 4-1 ATS in their past five games. They’re also 4-1 ATS in their last five games against NFC opponents, as well as in their last five times facing an NFC West club. The Lions are 2-2 ATS this season as a double-digit underdog. Arizona is 1-0 ATS as a double-digit favorite. Take the Cardinals and lay the 13.5 points. You can get Arizona -13.5 (-110) at BetMGM.

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Cardinals vs Lions Totals

Four of Arizona’s last five games have gone over. Detroit’s last two games have both gone over. The total has also gone over in each of Arizona’s last six visits to Detroit. Overall, the over is 12-5 in the past 17 games between the Lions and Cardinals. However, the under has carried the day in eight of Detroit’s last 11 games.

Seven Arizona games have gone over this season. Only Minnesota (eight) and Indianapolis (eight) have gone over more among the NFL’s 32 teams. At 47.5 points, the total isn’t especially large in the NFL picks market. The over is the play.

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