Marcus Mosher for Bookies.com

By Marcus Mosher | | 8 mins

Cardinals vs Rams Picks & Betting Predictions NFL Week 4

Cardinals vs Rams Picks & Betting Predictions NFL Week 4
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The best game of NFL Week 4 will feature two undefeated NFC West teams facing off in Week 4. The 3-0 Arizona Cardinals will visit the 3-0 Los Angeles Rams for first place in the division. Both teams have Super Bowl aspirations in 2021 and the winner of this game will have a huge advantage over the rest of the division after the first month of the season.

To get you ready for this NFC West matchup, here is everything you need to know from an NFL betting perspective.

Check out the latest Rams vs Cardinals odds, betting lines, injury report and more.


RELATED: NFL Week 4 Odds & Analysis For Every Game


Cardinals vs. Rams Key Matchups

Cardinals WR DeAndre Hopkins vs. Rams CB Jalen Ramsey: These two players have combined for five All-Pro seasons. The winner of this matchup will likely decide the final outcome of the game.

Rams LT Andrew Whitworth vs. Cardinals DE Chandler Jones: Jones had 5 sacks in Week 1, but none since. Will he get shut out again in Week 4?

Rams WR Cooper Kupp vs. Cardinals CB Byron Murphy: Kupp leads the NFL in receiving yards after three weeks, but Murphy is quickly turning into one of the league’s best slot cornerbacks.

5 Cardinals vs. Rams Stats

8: Consecutive losses by the Cardinals to the Rams.

10: Rams victories in their last 12 home games.

1: The Cardinals have the No. 1 ranked offense in the NFL, averaging over 34 points per game.

3: The Rams have the No. 3 ranked offense in the NFL, averaging nearly 32 points per game.

2-1: Both teams record against the spread through three weeks.

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Cardinals vs. Rams Player Props To Back

Cardinals RB James Connor To Score Anytime TD

Odds: +190 at DraftKings

When the Cardinals get near the goal line, Connor is the preferred back in Arizona. With this game expected to be such a high-scoring contest, Connor should get multiple goal-line carries.

Rams WR Cooper Kupp, Over 82.5 Receiving Yards

Odds: -110 at DraftKings

No receiver in the NFL has been more productive than Kupp this season. He is being peppered with targets and is fantastic after the catch. Look for that production to continue in this NFC West shootout.

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Cardinals QB Kyler Murray’s Longest Rush Over 11.5 yards

Odds: -115 at DraftKings

Murray is going to be forced to move around a ton in this game due to Aaron Donald and the rest of the pass rush for the Rams. He’s going to need his legs to create, and he should have multiple rushes of at least 15 yards in this game.


RELATED: NFL Week 4 Picks & Best Bets For Every Game


Cardinals vs. Rams Moneyline

Despite both teams starting off the season at 3-0, the Rams appear to be the more well-rounded squad. Their win against the Buccaneers in Week 3 proved that they can hang and beat even the best teams in the league.

While Arizona has been impressive to start the season – certainly great news for local fans with Arizona sports betting live – their wins just haven’t been quite as impressive. In fact, they probably should have lost to the Vikings (at home) if it wasn’t for a short missed field goal at the end of the game.

Because this is a divisional game, expect it to be close. But take the Rams at home on the moneyline at BetMGM. However, be sure to shop for the best odds on your favorite betting apps and sportsbooks as they can differ in a big way.

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Cardinals vs. Rams Point Spread

The Cardinals have not had a lot of success against the Rams over the past four seasons. Arizona’s defense just hasn’t been able to slow down Sean McVa’s offense. Not only have the Cardinals lost eight-straight games to the Rams, but they have yet to cover in any of those matchups.

With Matthew Stafford playing at an MVP level and the defense clicking, this is a game Los Angeles should win by more than a touchdown. Take the Rams -4 on DraftKings , but be sure to look for the best NFL spreads as game time draws near as some sites may have better odds closer to kickoff.

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Cardinals vs. Rams Totals

With both of these offenses averaging over 31 points per game this season, it’s fair to expect a ton of points. That is why the total is set at 55 points, which is the highest of the week. So, if you believe this is going to be a close game, can each side get to at least 28 points? You would think so.

However, it’s important to remember despite both of these offenses being elite, divisional games tend to be lower-scoring and the pace is slower. Expect a ton of points to be scored but take the under at FanDuel to hit in Los Angeles as both defenses turn up the intensity.

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About the Author

Marcus Mosher for Bookies.com
Marcus Mosher
Marcus Mosher covers the NFL for Bookies.com. The managing editor of The Raiders Wire is also a contributor to The Athletic DFW, Pro Football Weekly and FanSided.