Cardinals vs Rams Picks & Betting Predictions NFL Week 4

The best game of NFL Week 4 will feature two undefeated NFC West teams facing off in Week 4. The 3-0 Arizona Cardinals will visit the 3-0 Los Angeles Rams for first place in the division. Both teams have Super Bowl aspirations in 2021 and the winner of this game will have a huge advantage over the rest of the division after the first month of the season.

To get you ready for this NFC West matchup, here is everything you need to know from an NFL betting perspective.

Check out the latest Rams vs Cardinals odds, betting lines, injury report and more.

RELATED: NFL Week 4 Odds & Analysis For Every Game

Cardinals vs. Rams Key Matchups

Cardinals WR DeAndre Hopkins vs. Rams CB Jalen Ramsey: These two players have combined for five All-Pro seasons. The winner of this matchup will likely decide the final outcome of the game.

Rams LT Andrew Whitworth vs. Cardinals DE Chandler Jones: Jones had 5 sacks in Week 1, but none since. Will he get shut out again in Week 4?

Rams WR Cooper Kupp vs. Cardinals CB Byron Murphy: Kupp leads the NFL in receiving yards after three weeks, but Murphy is quickly turning into one of the league’s best slot cornerbacks.

5 Cardinals vs. Rams Stats

8: Consecutive losses by the Cardinals to the Rams.

10: Rams victories in their last 12 home games.

1: The Cardinals have the No. 1 ranked offense in the NFL, averaging over 34 points per game.

3: The Rams have the No. 3 ranked offense in the NFL, averaging nearly 32 points per game.

2-1: Both teams record against the spread through three weeks.

Bet $1, Double Your Winnings Your Next 10 Bets Promo Code: BOOKIESDYW

Tap for Promo Activated! Visit site

Used 70 Times Today

Must be 21+ to participate. T&Cs apply.

Cardinals vs. Rams Player Props To Back

Cardinals RB James Connor To Score Anytime TD

Odds: +190 at DraftKings

When the Cardinals get near the goal line, Connor is the preferred back in Arizona. With this game expected to be such a high-scoring contest, Connor should get multiple goal-line carries.

Rams WR Cooper Kupp, Over 82.5 Receiving Yards

Odds: -110 at DraftKings

No receiver in the NFL has been more productive than Kupp this season. He is being peppered with targets and is fantastic after the catch. Look for that production to continue in this NFC West shootout.

Bet $5, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 20 Times Today

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK.

Cardinals QB Kyler Murray’s Longest Rush Over 11.5 yards

Odds: -115 at DraftKings

Murray is going to be forced to move around a ton in this game due to Aaron Donald and the rest of the pass rush for the Rams. He’s going to need his legs to create, and he should have multiple rushes of at least 15 yards in this game.

RELATED: NFL Week 4 Picks & Best Bets For Every Game

Cardinals vs. Rams Moneyline

Despite both teams starting off the season at 3-0, the Rams appear to be the more well-rounded squad. Their win against the Buccaneers in Week 3 proved that they can hang and beat even the best teams in the league.

While Arizona has been impressive to start the season – certainly great news for local fans with Arizona sports betting live – their wins just haven’t been quite as impressive. In fact, they probably should have lost to the Vikings (at home) if it wasn’t for a short missed field goal at the end of the game.

Because this is a divisional game, expect it to be close. But take the Rams at home on the moneyline at BetMGM. However, be sure to shop for the best odds on your favorite betting apps and sportsbooks as they can differ in a big way.

$1,500 Paid Back in Bonus Bets If You Don't Win Promo Code: BOOKIES

Tap for Promo Activated! Visit site

Used 65 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate. Gambling problem? Call 1-800-GAMBLER (CO, DC, IL, IN, KY, LA, MD, MS, NC, NJ, OH, PA, TN, VA, WV, WY) Call 877-8-HOPENY or text HOPENY (467369) (NY). Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.

Cardinals vs. Rams Point Spread

The Cardinals have not had a lot of success against the Rams over the past four seasons. Arizona’s defense just hasn’t been able to slow down Sean McVa’s offense. Not only have the Cardinals lost eight-straight games to the Rams, but they have yet to cover in any of those matchups.

With Matthew Stafford playing at an MVP level and the defense clicking, this is a game Los Angeles should win by more than a touchdown. Take the Rams -4 on DraftKings , but be sure to look for the best NFL spreads as game time draws near as some sites may have better odds closer to kickoff.

Bet $5, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 18 Times Today

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK.

Cardinals vs. Rams Totals

With both of these offenses averaging over 31 points per game this season, it’s fair to expect a ton of points. That is why the total is set at 55 points, which is the highest of the week. So, if you believe this is going to be a close game, can each side get to at least 28 points? You would think so.

However, it’s important to remember despite both of these offenses being elite, divisional games tend to be lower-scoring and the pace is slower. Expect a ton of points to be scored but take the under at FanDuel to hit in Los Angeles as both defenses turn up the intensity.

Bet $5, Get $250 in Bonus Bets if Your Bet Wins!

Tap for Promo Activated! Visit site

Used 23 Times Today

Must be 21+ to participate. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, KY, MI, NJ, OH, PA, IL, TN, VA, VT), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), visit www.mdgamblinghelp.org (MD), 1-800-522-4700 (WY), or visit www.1800gambler.net (WV). GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY).