Carson Wentz and the Indianapolis Colts picked up win No. 1 last Sunday at Miami, but this road stop will be a little tougher as they head east to face Lamar Jackson and the Baltimore Ravens on Monday Night Football.

The NFL Week 5 prime-time matchup features run-first offenses and defenses that can shut opponents down – but don’t always bring their best game. Betting sites and betting apps have installed Baltimore as a seven-point favorite, with an Over/Under of 47 points in the latest Colts vs. Ravens odds.

But is this among the NFL spreads to attack or avoid?

Check out the latest Ravens vs. Colts odds, betting lines, injury report and more.

Colts vs. Ravens Key Matchups

Lamar Jackson vs. Colts LBs: Jackson’s 279 rushing yards ranks most among QBs and eighth overall. The Colts allowed 56 yards rushing by Ryan Tannehill two weeks ago, but no more than nine to any other QB, including Russell Wilson.

Colts RBs In Pass Game vs. Ravens D: Baltimore’s defense has surrendered 219 pass yards through the air to RBs, 26 receptions on 29 targets. Indy backs Nyheim Hines (14 receptions) and Jonathan Taylor (11 receptions) rank third and fifth on the team in catches and targets.

Latavius Murray vs. Colts Run D: Murray has been handed the RB1 spot for the Ravens but is averaging just 3.4 yards per carry. Indy ranks 15th in rush yards allowed per game and yards per rush (4.2).

RELATED: NFL Week 5 Odds & Betting Lines For All Games

5 Key Colts vs. Ravens Stats

5: Rushing TDs allowed by the Ravens; only the Lions have allowed more through four weeks. The Colts are 1-0 when Jonathan Taylor scores, and 0-3 when he doesn’t.

4.7: Combined field goals made per game for these teams, both in the top five.

11: Touchdowns through the air allowed by the Colts defense, tied with the Buccaneers and Falcons for the most in the NFL. Lamar Jackson has only four TDs through the air.

.167: The win percentage of Colts games played without T.Y. Hilton since the team drafted him in 2012. Indy is just 2-10, though that includes a Week 4 win over the Dolphins.

170: Yards passing per game allowed by the Ravens the last two weeks, both wins. Carson Wentz has averaged 192 yards vs. Baltimore in two games but more than that in all four Colts games this season.

Colts vs. Ravens Weather Forecast

M&T Bank Stadium in Baltimore should see cloudy but rain-free skies on Monday night. Highs during the day are a pleasant 79 degrees, with temperatures likely to hover around 70 degrees for the evening kickoff.

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Colts vs Ravens Player Props

Sammy Watkins, Over 40.5 Receiving Yards

Odds: -115 at DraftKings

Watkins has had exactly four receptions in all four Ravens games. He’s had at least 44 yards in each game as well. He can continue playing that role and cruise past this number. His 16 yards per reception this season would ensure he gets there with three catches.

Lamar Jackson, Over 293.5 Total Yards

Odds: -115 BetMGM

Jackson’s rushing numbers have gone down each week this season. But his passing yards have risen each week. He’s attained 321 yards in every game and a consistent 344-346 in each of the last three. This number seems quite low.

Latavius Murray, Under 51.5 Rushing Yards

Odds: -120 at DraftKings

Murray had 18 carries for 59 yards in last week’s win over the Broncos, but the 3.3 per rush average wasn’t good, nor is his 3.4 season average. Devonta Freeman’s carries have gone down the last two games, but his 6.8 average might get him more action, and Lamar Jackson’s legs could get in the way of more Murray rushes.

Justin Tucker, Over 7.5 Points

Odds : -115 BetMGM

Tucker is averaging nearly 10 points per game. He has 10 field goals and nine extra points and we know his range is extraordinary. Let’s hope the Colts can get 1-2 stops inside the 40 and let Tucker do his thing.

Colts vs. Ravens Moneyline

The Ravens are at -330 on the moneyline, meaning it would take a $330 wager to win $100 in profit. Conversely, the underdog Colts are +260 (a $100 win means $260 in profit). It’s a moneyline spot that sportsbooks are enticing fans of both sides to consider.

The Ravens are favored for a reason, but that is a high price to pay against the better of the two defenses. Baltimore’s D has been better of late, but Indy’s offense showcased its potential in a 27-17 win over the Dolphins in Week 5. There are too many variables to wager -330, and we’re not backing the Colts to win on the road here.

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Colts vs. Ravens Point Spread

The Ravens are at -7 on the point spread, moving from the original line of -6.5. That prompted major money on Baltimore early on. Is either side now worthy to toss some of your bankroll on a Week 5 NFL betting Monday night lineup?

If you’re picking a side, the Ravens is the one to go with. They’ve held their last two opponents to 24 total points, and beat the Chiefs the week prior. The Colts are a work in progress, and most matchups favor the Ravens anyway. Carson Wentz could be in for a very long night. Baltimore -7 is the best bet if adding MNF to your NFL picks lineup. You can get the Ravens -7 (-110) at DraftKings.

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Colts vs. Ravens Totals

The Over/Under for Monday Night Football sits at 47, down a solid 2.5 points from the line posted following Week 4 action. Combined, the Ravens and Colts average 47 ppg and allow 47.2 ppg.

That’s just one reason why the Under is enticing here. Each team is predicated by a strong defense and establishment of a rushing attack on offense. When the two teams have met, that’s exactly what has occurred. The Under has hit in 12 of the last 13 meetings between these teams. Signs suggest another slugfest that ends Under the total here. You can get Under 47 (-110) at FanDuel.

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