It’s time for another beautiful Saturday of college football betting,  as the national title picture begins to take shape and key conference matchups finally get underway.  

That includes a Game of the Week in the SEC, with No. 11 Tennessee favored by -10.5 at home against No. 20 Florida. We’ve also got Big Ten under the lights with Wisconsin a whopping +19.5 underdog in Columbus against No. 3 Ohio State.

We’ve got it all covered with picks and best bets, as well as a pair of three-leg Week 4 college football parlays on betting sites to sweeten the pot as the college gridiron action heats up.

RELATED: College Football Week 4 Odds, Best Bet and Picks

Best College Football Week 4 Parlay Bets To Back

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Leg 1: Michigan State +2.5 over Minnesota

The Spartans were humbled big time in last week’s blowout loss at Washington, but we’re surprised to see they’re already home underdogs. That kicks off our first week 4 CFB parlay featuring a trio of Big Ten dogs. Michigan State has eight straight home wins under Mel Tucker, and the Spartans haven’t lost to an unranked opponent at home since the very first game of his tenure in 2020. 

Minnesota hasn’t won in East Lansing since 2006, and we think the Spartans front seven matches up well here to stop a potent Gophers rushing attack. No. 1 receiver Jayden Reed is still questionable after missing the Washington game due to injury, and we definitely like the Spartans to win outright if he’s back in the lineup. Either way, we expect a cover behind a strong home crowd. 

Leg 2: Rutgers +8 over Iowa

The total for this game is set at 34, which is all you need to know. Rutgers and Iowa have two of the best defenses in the country and two of the worst offenses, with the potential for an all-time punt-fest on tap in New Jersey. With a total that low, and an offense as bad as the Hawkeyes, we can’t justify giving more than a touchdown. 

Rutgers might actually be decent this year and an early lead for the Knights – even by a field goal or two – could look insurmountable for an incompetent Iowa offense. 

Leg 3: Wisconsin +19.5 over Ohio State

The college football spreads continue to creep up for Wisconsin here, with the Badgers moving from +18 to +19.5 as of Friday afternoon. This game always looks like a massive mismatch on paper due to the contrasting styles. It’s impossible for the Badgers to take a typical grind-it-out approach because Ohio State’s offense can put up 14 points in a blink. It takes Wisconsin out of its gameplan and makes things miserable on the starting quarterback, dropping back in obvious passing situations for a unit that isn’t built to win that way. 

But these matchups often play out much closer than expected – the Buckeyes have won eight in a row over Wisconsin, but five of those victories were by seven points or less. And we’re still a little hesitant to go all-in on these Buckeyes given what we saw in an ugly Week 1 home win over Notre Dame. 

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Our Second College Football Week 4 Best Parlay

Leg 1: South Florida +14.5 over Louisville

The Bulls head to Louisville after giving No. 18 Florida a serious scare in last week’s 31-28 loss. They catch a 1-2 Louisville team coming off a close loss to Florida State, with the Cardinals blowing a fourth-quarter lead. That sets the tone for our second week 4 parlay, in which we’re fading three coaches on the hot seat – starting with Louisville’s Scott Satterfield. 

We think this game is closer than the line indicates, one in which the pressure is on big time for Satterfield and a struggling Louisville program. We'll take the points on betting apps for this one.

RELATED: 2022 Heisman Trophy Betting Odds Tracker

Leg 2: UCF -20.5 over Georgia Tech

This could be the last week for Georgia Tech coach Geoff Collins, who is definitely out of time on this Yellow Jackets rebuild attempt. Georgia Tech was completely uncompetitive in last week’s loss to Ole Miss and will be in over its head again this week. The Yellow Jackets’ secondary is a big problem and UCF can air it out. There’s no way Georgia Tech can keep pace in this one, and it could get very ugly in the second half. 

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Leg 3: North Carolina -2 over Notre Dame

The Irish came dangerously close to an 0-3 start last week, sneaking past an upset-minded Cal team. It doesn’t get any easier with the Irish taking on an undefeated Tar Heels team coming off a bye in North Carolina. The Tar Heels have already been in a pair of dog fights with scrappy nonconference opponents, outlasting Appalachian State and Georgia State in the early going. 

Now they have a chance to really build some momentum with the biggest win to date, and the Irish are under tremendous pressure to turn things around in a hurry under first-year coach Marcus Freeman. We’re not sure they have the pieces to do it.