ALCS Odds: Red Sox vs Astros Picks, Predictions & Betting Preview

The stage is set for the American League Championship Series, as the Houston Astros return to take on the Boston Red Sox. The Red Sox took a longer route, going through the one-game wild-card round first before knocking off the reigning AL champion Rays in four games. For the Astros, a simple 3-1 series win over the White Sox allowed them to punch a ticket to this round.

The favored Astros receive home-field advantage. Check out the MLB odds, as well as our MLB picks for this series, below.

Odds via FanDuel are current as of publication. betting sites may indicate odds changes closer to Game 1 on Friday.

Bet $5, Get $200 in Bonus Bets if Your Bet Wins!

Tap for Promo Activated! Visit site

Used 56 Times Today

Must be 21+ to participate. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, KY, MI, NJ, OH, PA, IL, TN, VA, VT), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), visit www.mdgamblinghelp.org (MD), 1-800-522-4700 (WY), or visit www.1800gambler.net (WV). GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY).

Why You Should Pick The Astros

It’s difficult to be a villain if you aren’t relevant. And let us tell you, the Astros sure are relevant. This marks their fifth consecutive trip to the ALCS, a staggering number that shouldn’t be overlooked (for context, the Twins have been to the ALCS once since 1992!).

The sign-stealing scandal is largely in the rearview, but this is a team many baseball fans love to hate. And that might just be because they’re so good. Carlos Correa, Jose Altuve, Alex Bregman, Yuli Gurriel and Lance McCullers Jr. have been on the team’s entire ride of success.

This postseason, Houston ranks second in team OPS (.803), second in runs (31) and first in stolen bases (five). McCullers has been a top-of-rotation bulldog (one run allowed in 10 2/3 innings), and Zack Greinke out of the bullpen is simply unfair.

Making a case for the Astros is easy. And sportsbooks already sort of made it for us, by giving Houston the shortest American League MLB futures odds when the division series began last week.

We’ve seen this team, with many of the same players, succeed on this stage for several years. And with a few key guys headed for free agency (Correa, Greinke, etc.), another AL pennant could serve as a last hurrah.

$1,500 Paid Back in Bonus Bets If You Don't Win Promo Code: BOOKIES

Tap for Promo Activated! Visit site

Used 16 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate. Gambling problem? Call 1-800-GAMBLER (CO, DC, IL, IN, KY, LA, MD, MS, NC, NJ, OH, PA, TN, VA, WV, WY) Call 877-8-HOPENY or text HOPENY (467369) (NY). Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.

Why You Should Pick The Red Sox

Alex Verdugo called the Red Sox “the best team in the AL East.” Like it or not, he’s technically correct.

This year’s AL East featured four 90-plus-win teams, the first division to accomplish that since 1994 (i.e., when MLB implemented three-division leagues). The Red Sox won their season series against the Blue Jays, toppled the Yankees in the wild-card round and now they’ve snuffed out the Rays in the division series. Boston is battle-tested, and from arguably the greatest division ever they’re the last ones standing.

Oh, and they’re tearing the cover off the ball. In five playoff games, Boston has a staggering team OPS of .919, to go along with MLB-highs in hits (63), runs (32) and home runs (11). Betting apps gave them the longest odds at an AL pennant when the division series started.

If you were bullish on Boston early, cheers to you. But if not, you’re not too late.

Bet $1, Double Your Winnings Your Next 10 Bets Promo Code: BOOKIESDYW

Tap for Promo Activated! Visit site

Used 58 Times Today

Must be 21+ to participate. T&Cs apply.

Our ALCS pick

When looking at the two hottest offenses in the postseason, it makes sense to look at the pitching staffs in search of an MLB betting differentiator. The Astros have a stronger, deeper rotation, while the Red Sox have more depth in the bullpen. With that said, we think Houston has enough relief options to carry them through — and their team-wide experience will help a bunch, too.

At +200 on DraftKings, the Astros now have the shortest World Series odds available. We like their chances to make it there.

The Pick: Astros in 6 at DraftKings

Bet $5, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 56 Times Today

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK.