Cardinals vs Giants Same Game Parlay Picks for MLB (Sep 22nd, 2025)

By Bookies.com Staff Sep 22nd, 2025 11:30 AM EDT

St. Louis Cardinals first baseman Alec Burleson (41). Tim Vizer-Imagn Images

Recent matchups at Oracle Park have tilted toward subdued scoring for the Giants, especially when hosting St. Louis. September 22nd’s National League meeting pairs San Francisco against a Cardinals club that has kept them under five runs in four of their last five encounters. On the visitors’ side, Brendan Donovan remains productive away from home with frequent multi-hit outings while Alec Burleson thrives in total bases during trips. This data-driven setup shapes our Best MLB same game parlay today.

Cardinals vs Giants Same Game Parlay Picks (Sep 22nd, 2025)

This combination leans on continued offensive effectiveness from St. Louis bats and limited output by San Francisco’s lineup. The player bases picks benefit from hot stretches by both Burleson and Donovan on the Cardinals’ roster lately, particularly on the road. Coupling these with an under bet for Giants team total aligns well given historical scoring trends between these teams.

Pick 1: Team Total – San Francisco Giants Under 4.5 – -154

San Francisco's offense often struggles when matched up against this particular opponent at Oracle Park as evidenced by their low run totals in past meetings with St. Louis—held to three or fewer runs in four of their last five attempts here—which points toward value taking them under again tonight especially considering neither lineup nor circumstance suggests a sudden breakout offensively is likely.

Pick 2: Player Bases – Alec Burleson Over 1.5 – +129

Alec Burleson's bat rarely cools off during extended trips away from Busch Stadium; he’s cleared two or more total bases across five out of his previous six games played outside St. Louis which makes him an appealing candidate to surpass this number once more at pitcher-friendly Oracle Park where his approach translates well regardless of venue nuances.

Pick 3: Player Bases – Brendan Donovan Over 1.5 – +113

Brendan Donovan keeps producing quality plate appearances as a visiting hitter; over his latest string of away dates he's managed multiple hits regularly—including recording two-plus knocks four times within only five such games—so backing him to reach this threshold fits both statistical patterns and current form heading into another favorable spot versus San Francisco pitching.

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