NFL Week 2 Picks: Taylor Swift Finance In Super Bowl Rematch

By Bill Speros Aug 29th, 2025 10:47 AM EDT

Jalen Hurts and Patrick Mahomes meet in Super Bowl rematch this week. (USA TODAY)

The NFL slotted the Super Bowl 57 and 59 rematch between the Chiefs and Eagles for Week 2. It headlines our Week 2 NFK picks.

Given that any game featuring the previous Super Bowl’s combatants provides ratings gold, the NFL’s decision to offer this game in Week 2 and not during the all-important November ratings period is a tell as to what the great minds on Park Avenue think of the odds for a rematch in Super Bowl 60.

Oddsmakers price a Chiefs-Eagles rematch at +2200. That’s still the No. 3 pick in the “Names The Finalist” market.

The Eagles lost significant talent this past offseason – mainly due to free agency. The Chiefs, meanwhile, saw their defensive front badly exposed by the Eagles’ running game and  Jalen Hurts’ ability to keep plays alive in Philly’s 40-22 SB59 romp. 

Read on for our Week 2 NFL picks to back on the best sports betting app. 

Mahomes Magic Put To Test - Again

Patrick Mahomes can only do so much.

With the official engagement announcement of “your English teacher and your gym teacher,”  this Eagles-Chiefs game should be another ratings diamond mine.

Our NFL Week 2 picks begin with a pair of playoff teams from last season as the Commanders visit the Packers on Thursday night in Amazon Prime’s first regular-season game. All 32 teams play this week. The Philly-at-Kansas City title rematch is the national game on FOX at 4:25. The Vikings play host to the Falcons in a Sunday night snoozer.

Bettors get a Monday night doubleheader and can wager on them at the best sports betting sites. Tampa Bay plays at Houston in the first game of the evening (7 p.m., ESPN), and the Chargers hit Sin City for the nightcap (10 p.m.; ESPN).   

2025-26 NFL Week 2 Best Bets: Odds & Picks

Now it’s on to our Week 2 NFL picks to back on your favorite sports betting app. 

Date	Matchup	Week 2 Picks
Thur. Sept. 11	Washington Commanders at Green Bay Packers	Commanders ML (+130) DraftKings
Sun. Sept. 14	Chicago Bears at Detroit Lions	Lions -4.5 (-110) DraftKings
Sun. Sept. 14	Buffalo Bills at New York Jets	Under 44.5 Points (-110) DraftKings
Sun. Sept. 14	Jacksonville Jaguars at Cincinnati Bengals	Jaguars +5.5 (-110) DraftKings
Sun. Sept. 14	New York Giants at Dallas Cowboys	Under 44.5 Points (-110) DraftKings
Sun. Sept. 14	LA Rams at Tennessee Titans	Titans +5.5 (-110) DraftKings
Sun. Sept. 14	New England Patriots at Miami Dolphins	Under 45.5 Points (-110) DraftKings
Sun. Sept. 14	San Francisco 49ers at New Orleans Saints	49ers -7 (-110) DraftKings
Sun. Sept. 14	Seattle Seahawks at Pittsburgh Steelers	Over 42.5 Points (-110) Caesars
Sun. Sept. 14	Cleveland Browns at Baltimore Ravens	Ravens -12.5 (-110) DraftKings
Sun. Sept. 14	Denver Broncos at Indianapolis Colts	Broncos -3.5 (-110) DraftKings
Sun. Sept. 14	Carolina Panthers at Arizona Cardinals	Panthers +4.5 (-110) DraftKings
Sun. Sept. 14	Philadelphia Eagles at Kansas City Chiefs	Eagles ML (+105) DraftKings
Sun. Sept. 14	Atlanta Falcons at Minnesota Vikings	Falcons +4.5 (-110) DraftKings
Mon. Sept. 15	Tampa Bay Buccaneers at Houston Texans	Buccaneers ML (+110) DraftKings
Mon. Sept. 15	Los Angeles Chargers at Las Vegas Raiders	Chargers -3 (+110) DraftKings

2025-26 NFL Week 2 Best Bets: Game-By-Game Analysis

Thursday, September 11
Washington Commanders at Green Bay Packers, 8:15 p.m. (Amazon Prime)

Buzz: NFL sophomore QB Jayden Daniels draws a difficult road test in Week 2. But he’ll have a very rich and happy Terry McLaurin catching the ball. Both teams reached the playoffs last year. This is the sort of game that could well end up determining home field if these teams end up meeting as wild cards in the playoffs. The Commanders carry the oldest roster in the NFL this season and should be ready for a Packers team that is the youngest in the league – boosted my Micah Parsons. His acquisition moved this line a half-point in Green Bay’s favor.

Best Bet: Commanders ML (+130) at DraftKings via OddsJam

Sunday, September 14
Chicago Bears at Detroit Lions, 1 p.m. (FOX)

Buzz: This week’s schedule features 5 intra-divisional matchups among our Week 2 NFL picks. This one carries the most weight. If the Bears want to assert their claim on the NFC North – this is the place to start. Detroit swept Chicago last season straight up but split against the line. This number is significantly tighter than both games last season – a nod to the Bears’ offseason upgrades via the draft and free-agency. Chicago leans fully into QB Caleb Williams this season. He’ll have time more time throw or take off on his own, but he was 34^th last season in passing from a clean pocket. The Lions face their former OC Ben Johnson, now coaching the Bears. Lions DE Aidan Hutchinson returns from a season-ending injury suffered in Week 6 last year and aims to make Johnson’s return to Detroit miserable.

Best Bet: Lions -4.5 (-115) at DraftKings via OddsJam

Buffalo Bills at New York Jets, 1 p.m. (CBS)

Buzz: The bags may be out at MetLife given that this is the Jets’ second straight home game to open the season. The Bills, meanwhile, underperformed against the line last season regarding their overall record by 3 games (15-5 vs 12-8, including the playoffs. Even with a stout offensive line, Justin Fields and the Jets depleted receiving corps face doom if the Bills can get 28 points on the board. The Bills locked up James Cook and scored solid grades in both free-agency and the draft. It’s “Super Bowl Or Bust” time for Josh Allen and Buffalo this season. No. Seriously. We really mean it this time.

Best Bet: Under 44.5 Points at DraftKings via OddsJam

Jacksonville Jaguars at Cincinnati Bengals, 1 p.m. (CBS)

Buzz: These 2 fickle felines end up kicking kitty litter when playoff time arrives. The Bengals own a notorious reputation for terrible starts and late-but-unsuccessful surges in the season. This is the sort of game the Bengals need if they don’t want to be in a deep pit around Thanksgiving. The Jaguars put the “mid” in middle of the road. This time, Trevor Lawrence gets to target Travis Hunter and 2024 rookie star Brian Thompson. The Jags’ defense won’t be able to keep pace with Cincy if Joe Burrow finds any sort of rhythm against a porous secondary. But this is a “weather game.” The Jags play opponents tight in early-season home games thanks to Florida’s heat and humidity.

Best Bet: Jaguars -5.5 (-110) at DraftKings via OddsJam

 New York Giants at Dallas Cowboys, 1 p.m. (FOX)

Buzz: We won’t put Dallas coach Brian Schottenheimer in the hot seat yet – unless the Cowboys somehow struggle against Big Blue. At least Schottenheimer -  who is coaching the Cowboys this season after Mike McCarthy was finally put out of his misery after last season – doesn’t begin the season atop the “First Coach To Be Fired” list. That honor belongs to NY’s Brian Daboll. The Daniel Jones Show opened for Indy last week. QB Russell Wilson leads the Giants into Jerry World. The total on this game seems terribly overpriced here among our NFL Week 2 picks. It’s hard to see BOTH teams scoring 3 TDs here. Even with Micah Parsons in Green Bay.

Best Bet: Under 44.5 (-110) at DraftKings via OddsJam

LA Rams at Tennessee Titans, 1 p.m. (CBS)

Buzz: Tennessee QB and No. 1 overall draft pick Cam Ward makes his home debut and will be protected by an overhauled offensive line. He catches the Rams in an early-for-them start. The Titans’ defensive strength is up front. And Matt Stafford does struggle under pressure. He turned the ball over while pressured 14 times last season – tied for most in the league. Stafford carries the best assortment of wideouts in the NFL – given the arrival of Davante Adams and his in-home Taco Bell for Cooper Kupp. The Titans defense determines the outcome of this game. They’ll pressure Stafford just enough to keep and close and score the cover.  

Best Bet: Titans +5.5 (-110) at DraftKings via OddsJam

New England Patriots at Miami Dolphins, 1 p.m. (CBS)

Buzz: Another Week 2 “weather” game in the Sunshine State. The Patriots historically struggle in Miami in day games both early and late in the season due to hot and humid Florida weather and the sun on the visitors’ side of the field at Hard Rock Stadium. And the contrast it offers to the weather in New England. Mike Vrabel’s plan will focus on dominating both sides of the line, running the ball a lot, and taking away Miami’s run and Tua’s ability to produce with his feet. Miami’s deep speed will burn New England. How many times determines the winner. We’ll lean into the under here given New England’s focus on ball control and defense.

Best Bet: Under 45.5 Points (-110) at DraftKings via OddsJam

San Francisco 49ers at New Orleans Saints, 1 p.m. (FOX)

Buzz: The Saints rode the Drew Brees train for 15 years. In the 5 years since, they’ve used 8 different starting QBs.  Spencer Rattler emerged from the QB room wreckage to nab the QB 1 spot this season (he started 6 games last season). Injuries ravaged the 49ers in 2024. This year’s team eyes a return to the Super Bowl. The 49ers whiffed this offseason in terms of free-agency and the draft, but they’re happy to reload with the core that got hurt last season. The rest of the league caught up to Brock Purdy last season, his passing grade after Week 7 was 28^th in the NFL. Still, a healthy 49ers team should score a win and cover on the full touchdown line against the CFL Saints.

Best Bet: 49ers -7 (-110) at DraftKings via OddsJam

Seattle Seahawks at Pittsburgh Steelers, 1 p.m. (FOX)

Buzz: Aaron Rodgers makes his home debut for the Pittsburgh Steelers in another marquee game among our Week 2 NFL picks. The Acrisure Stadium crowd should be fully lubricated some kickoff. Sam Darnold gets his shot to silence the home crowd. Mike Tomlin wants keep A-Rod on a tight leash. But that won’t stop Rodgers from testing his limits and that of the Seahawks’ secondary. This may the surprise offensive shootout of the week. Especially with Pittsburgh WR D.K. Metcalf going up against his former teammates.

Best Bet: Over 42.5 Points (-110) at Ceasars Sportsbook via OddsJam

Cleveland Browns at Baltimore Ravens, 1 p.m. (CBS)

Buzz: Another Baltimore homecoming for Joe Flacco. The Ravens won’t be talking prisoners this season. Naturally, the Browns upset Baltimore in 2024, winning outright as 7.5-point underdogs. The Ravens found balance with a 25-point win home over Cleveland in Week 18, covering an improbable 19.5-point line. The Browns won’t be fooling anyone this season. Look for the home team to deliver a curb-stomping, possibly a shutout. Think 27-0 ish.

Best Bet: Ravens -12.5 (-110) at DraftKings via OddsJam

Denver Broncos at Indianapolis Colts, 4:05 p.m. (CBS)

Buzz: The Colts ride into Week 2 with Daniel Jones holding the QB reins. Anthony Richardson won’t miss the beating he would have taken at the hands of the Broncos defense. Bo Nix offers strong upside potential for the fantasy and/or prop crowd this week. These road dogs bark and bite.

Best Bet: Broncos -3.5 (-110) at DraftKings via OddsJam

Carolina Panthers at Arizona Panthers, 4:05 p.m. (CBS)

Buzz: This may be the least-watched NFL game since the merger. Not only is it limited to just the Carolina and Arizona markets, but it’s also going up against the Super Bowl rematch and Taylor Swift. Bettors can shake it off and take the Panthers and the points.

Best Bet: Panthers +4.5 (-110) at DraftKings via OddsJam

Philadelphia Eagles at Kansas City Chiefs, 4:25 p.m. (FOX)

Buzz: Our NFL Week 2 picks main event delivers the defending Super Bowl champions in a rematch at Kansas City, complete with Taylor Swift rooting for her betrothed Travis Kelce and Tom Brady breaking it down in the FOX booth. The Eagles remain stacked, despite being drained by free agency, especially on defense, and losing their OC to the Saints. The NFL scheduling this game in Week 2 – as opposed the prime spot on the Sunday before Thanksgiving – is a tell that Park Avenue has little faith in a Super Bowl rematch this season. KC went 12-0 in one-score games last season. We’ll know by 8 p.m. ET if the Mahomes Magic remains intact. This line matches the Super Bowl opening number – a game Philly won by 18.

Best Bet: Eagles ML (+105) at DraftKings via OddsJam

Atlanta Falcons at Minnesota Vikings, 8:20 p.m. (NBC)

Buzz: Two QBs taken in the first round of the 2024 NFL draft take center stage in prime time. Falcons QB Michael Penix Jr. continues his first season as the QB of the present and future. He’s got the skills and the skill position players to finally get the Falcons over the hump in the NFC South. The Falcons’ defense has even more to prove. The Vikings rode Sam Darnold as their Icarus last season. He took them straight into the postseason sun before melting and taking the Vikings’ ship with him crashing back to earth. Minnesota rides with J.J. McCarthy. His rookie campaign ended before it began in training camp last season. The Vikings defense behind Brian Flores tips the scales for the home team. But not at this price.  

Best Bet: Falcons +4.5 (-100) at DraftKings via OddsJam

Monday, September 15
Tampa Bay Buccaneers at Houston Texans, 7 p.m. (ABC/ESPN)

Buzz: Houston QB C.J. Stroud took the second-most sacks in the NFL last season and will be on the run again this week given the troubles that remain on the Texans’ offensive line. The Texans begin the season without Joe Mixon. Houston needs to get its special teams right if it hopes to compete against Tampa Bay this week and contend down the stretch. The Buccaneers have not missed the postseason since acquiring Tom Brady in 2020. Baker Mayfield leads a veteran Tampa Bay team that will go as far as its defense will allow. This week, that means an upset win on the road at Houston.

Best Bet: Buccaneers ML (+110) at DraftKings via OddsJam

Los Angeles Chargers at Las Vegas Raiders, 10 p.m. (ESPN)

Buzz: Tom Brady may be walking through the door in Las Vegas, but he won’t be in uniform. This one’s a must-win for LA if the Bolts want to avoid having to sweat a playoff berth come Week 18.

Best Bet: Chargers -3 (+110) at DraftKings via OddsJam