Cardinals vs. Cowboys Odds, Best Bets & Player Props For MNF NFL Week 10

By Adam Thompson Nov 3rd, 2025 12:42 PM EST

Arizona Cardinals quarterback Jacoby Brissett (7)

NFC squads in need of a turnaround moment face off in the Week 9 edition of Monday Night Football, as Dak Prescott and the Dallas Cowboys host Kyler Murray and the Arizona Cardinals.

The Cowboys (3-4-1) were blown out by the Broncos last week, and have one more game before a bye to recharge. The Cardinals (2-5) have dropped five straight, all of them in heartbreaking fashion.

The latest Cardinals vs. Cowboys NFL Odds has Dallas at -3.5, a line that’s moved after Arizona QB Kyler Murray was deemed unlikely to play. The Over/Under for total points is at 53.5.

Bookies.com veteran NFL handicapper Adam Thompson – who has hit on a whopping 60.2% of his NFL picks five years running, reveals his plays for this important primetime matchup.

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Cardinals vs. Cowboys Betting Predictions

Cardinals vs. Cowboys Point Spread

Who do we trust less, a Cardinals team that’s lost five in a row by a combined 13 points, or a Dallas side that’s won games by 20 and 15 points and lost them by 17 and 20, with a 40-40 tie thrown in there?

The Cowboys’ offense ranks No. 2 in yards and in scoring, and that’s who we’ll trust here. Jacoby Brissett is under center again for Arizona, and frankly it’s not a big dropoff from Murray. But the team’s lack of a rush attack allows the Cowboys’ porous defense to put more resources to the pass attack. Dallas -3.5 is the better play.

Cardinals vs. Cowboys Over/Under

The Over has hit in the Cardinals’ last three games. The two Brissett starts, 50 and 58 points were scored.

Dallas scores and allows points with the best of them. Five straight Cowboys games have had at least 57 points, and that includes matchups with the punchless Jets and Panthers. We’ll side with the Over as our top MNF play.

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Cardinals vs. Cowboys Same Game Parlay

1. Over 53.5 Points: Arizona scores when Brissett plays and Dallas’ defense is a mess. The Cowboys have scored 37-plus points in half their games. The Cards can defend, but their D has given up their most points the last two weeks.

2. Jacoby Brissett, Over 250.5 Pass Yards: Cards coach Jonathan Gannon has shown more confidence in Brissett leading the air attack over Murray. In his two starts, he’s thrown it 36 and 44 times, and totaled 279 and 320 yards.

3. Zay Jones, Over 22.5 Receiving Yards: In four games with Murray as QB, Jones had five receptions for 37 yards. In two games with Brissett, he’s totaled seven receptions and 145 yards. The Cowboys rank 31st in pass defense.

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