Dolphins vs. Bills Odds, Best Bets & Player Props For TNF NFL Week 3

By Adam Thompson Sep 16th, 2025 6:01 PM EDT

Buffalo Bills helmets at Raymond James Stadium. (Photo by Marty Jean-Louis/Sipa USA)

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Josh Allen and the Buffalo Bills look to keep their torrid start to the 2025 NFL season going, as they host Tua Tagovailoa and the struggling Miami Dolphins in the Week 3 edition of Thursday Night Football.

The Bills (2-0) have scored 71 points through two games, while the Dolphins (0-2) have surrendered 66 to far less prolific offenses.

The latest Dolphins vs. Bills NFL Odds at the best sports betting sites have Buffalo favored by 11.5 points, a line that’s as high as 12.5 points at some online sportsbooks. The Over/Under for total points is at 49.5 points.

Bookies.com veteran NFL handicapper Adam Thompson – who has hit on a whopping 60.2% of his NFL picks five years running- reveals his plays for this AFC East showdown.

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Dolphins vs. Bills Betting Predictions

Dolphins vs. Bills Point Spread

Buffalo has the best offense in the NFL right now. It’s scored 41 and 30 points, and one of those games was a sleepy cakewalk. The Bills rank No. 1 in yards, too.

Still, as bad as Miami has been in its 0-2 start, this is a lot of points for a team with the weapons it possesses. The Dolphins scored 33 points in Week 2. Scoring somewhere in the mid-20s here should be enough to cover this spread. Back Miami at +12.5 as a secondary play for Thursday night.

Dolphins vs. Bills Over/Under

The Dolphins are coming off a 33-27 shootout loss to a Patriots team that managed only 13 points prior. Buffalo might hit 40 again on its own, or at least in the 30s. Let’s not forget, however, that Miami can put up points and hasn’t stopped anyone.

Miami isn’t Baltimore, but the Bills did surrender 40 in their season opener, also at night, also at home. Buffalo’s suspect front 7 offers hope that Miami can find a ground attack, opening up the play-action calls for Mike McDaniel. Back the Over as the top play for TNF.

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Dolphins vs. Bills Same Game Parlay

1. Over 49.5 Points (-110): The Bills have yet to score under 30, the Dolphins have yet to allow fewer than 33. Buffalo’s defense can certainly have lapses, and Miami has weapons. It has the feels of a 35-24 type of game.

2. DeVon Achane, Over 54.5 Rushing Yards (-110): The Dolphins’ lead RB rushed for 55 yards on only 11 carries in Week 1. He got 11 carries in Week 2 but managed just 30 yards. The Bills have given up 338 rushing yards through two weeks, and Miami’s offense functions far better when the run game is established.

3. James Cook, Over 8.5 Receiving Yards (-115): The Bills RB had only one catch for three yards last week vs. the Jets. The week prior, however, he had 5-for-58. Miami has given up 146 receiving yards to RBs through just two weeks.

Same Game Parlay Odds: +581

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