Seahawks vs. Cardinals Odds, Best Bets & Player Props For TNF NFL Week 4

By Adam Thompson Sep 23rd, 2025 5:19 PM EDT

Kyler Murray (AP Photo/Butch Dill)

Tap for Promo Visit site

Bet $10, Get $100 In FanCash + Up To $100 Back in FanCash Every Football Gameday

Used 51 Times Today

21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

A pair of 2-1 NFC West teams look to gain an early edge in the standings, as Kyler Murray and the Arizona Cardinals host Sam Darnold and the Seattle Seahawks on Thursday Night Football for Week 4.

Arizona suffered a walk-off 17-15 loss to the 49ers last Sunday, while Seattle overpowered the Saints in a 44-13 rout.

The latest Seahawks vs. Cardinals NFL Odds has road-side Seattle favored by 1.5 points at the best sports betting sites. The Over/Under for total points is at 43.5 points.

Bookies.com veteran NFL handicapper Adam Thompson – who has hit on a whopping 60.2% of his NFL picks five years running- reveals his plays for this divisional matchup.

Tap for Promo Visit site

$1,500 Paid Back in Bonus Bets If You Don't Win
Promo Code: BOOKIES

Used 22 Times Today

Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR) 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.

Seahawks vs. Cardinals Betting Predictions

Seahawks vs. Cardinals Point Spread

Buffalo has the best offense in the NFL right now. It’s scored 41 and 30 points, and one of those games was a sleepy cakewalk. The Bills rank No. 1 in yards, too.

Still, as bad as Miami has been in its 0-2 start, this is a lot of points for a team with the weapons it possesses. The Dolphins scored 33 points in Week 2. Scoring somewhere in the mid-20s here should be enough to cover this spread. Back Miami at +12.5 as a secondary play for Thursday night.

Seahawks vs. Cardinals Over/Under

Lineup for lineup, there aren’t many key advantages for either offense to truly exploit. In fact, it might be the other way around. While Seattle doesn’t have a key spot, the Cardinals’ defense has edges vs. both the run and the pass of the Seahawks, but not enough to go all-in on a game outcome.

Seattle has yet to allow more than 17 points, and both Cardinals games that have posted O/U of below 45 points had finished with 33 and 31 total points. We’ll back the Under as the top play for TNF.

Tap for Promo Visit site

Bet $5, Get $200 in Bonus Bets Win or Lose
Promo Code: BOOKIES

Used 77 Times Today

Must be 21+ to participate. Gambling problem? Call 1-800-GAMBLER (CO, IL, IA, KY, KS, LA, MD, NC, NJ, OH, PA, TN, VA). Call 1-800-NEXT-STEP (AZ). Call 1-800-9-WITH-IT (IN). Deposit required. Paid in Bonus Bets. Bets wager excluded from returns. New Customer only. T&Cs, time limits and exclusions apply. Code is for marketing/tracking purposes.

Seahawks vs. Cardinals Same Game Parlay

1. Under 43.5 Points (-110): The trends through three weeks point to a closer game, one with limited scoring opportunities.

2. Trey Benson, Over 15.5 Rush Attempts (-104): Balance has been the goal for Jonathan Gannon’s Cardinals. Arizona is averaging 25.6 rush attempts per game but must move forward without James Conner, out for the season due to injury. As the RB1 last season, Conner had 15-plus carries 11 times.

3. Sam Darnold, Under 8.5 Rushing Yards (-116): Darnold isn’t going anywhere if he doesn’t have to. He has just two rush attempts all season, and none in the last two games. The Cardinals have seen just seven rush attempts to opposing QBs (fourth-fewest) for 30 yards (fifth-fewest).

Same Game Parlay Odds: +597

Tap for Promo Visit site

Bet $1, Double Your Winnings Your Next 20 Bets
Promo Code: BOOKIES20X

Used 8 Times Today

Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA). 21+ only. Please Gamble Responsibly. Terms and conditions apply. Subject to eligibility requirements. Bonus bets are non-withdrawable. This promotional offer is not available in Mississippi, Nevada, Ontario, or Puerto Rico.