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Dallas Cowboys vs San Francisco 49ers Odds, Picks & Predictions

Adam Thompson for Bookies.com

Adam Thompson  | 5 mins

Dallas Cowboys vs San Francisco 49ers Odds, Picks & Predictions

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Brock Purdy and the San Francisco 49ers look to keep a dominant string of wins rolling, as they host Dak Prescott and the Dallas Cowboys in a marquee Sunday evening NFL Playoffs Divisional Round matchup. 

San Francisco, the No. 2 seed in the NFC, hasn’t lost a game since Purdy, the No. 3 QB on the roster, took over for the offense. The team has won 11 in a row overall, while the Cowboys already have one road playoff win under their belts, ending Tom Brady’s season with a thorough 31-14 win in Tampa. 

The latest Cowboys vs. 49ers odds at NFL betting sites give San Francisco only a slight edge plus home-field advantage, favored by four points, with an Over/Under for total points set at 46 at sports betting apps

Bookies.com NFL handicapper Adam Thompson – focused on hitting over 60% of his NFL picks for a fourth-consecutive season – reveals his picks and props for the important rematch. 

Cowboys vs. 49ers Point Spread Pick

There isn’t much to pick on when it comes to the 49ers. Brock Purdy has obviously exceeded expectations, but the run game, the receivers and the defense are top shelf. If Purdy continues what he’s doing, San Francisco is going to the Super Bowl. 

But the Cowboys offense, when humming, rivals the Chiefs and Bills. Take away the season finale vs. Washington and the last 10 games Dak Prescott has started, Dallas is averaging 35.8 ppg. 

Only two offenses have put up 30 on the Niners, the Chiefs and the similarly built Raiders. The number is key; jump on the Cowboys at +4. 

Cowboys vs. 49ers Over/Under Best Bet

The 49ers defense might be best in the league, but San Francisco games are regularly hitting over. It’s cashed in four straight and in six of seven overall, and five straight at home. Dallas games have hit Under three straight times, but that’s due to a defense that’s allowed 17.6 ppg in those games. 

Dallas is unlikely to allow 14 points or less for a third time in four weeks. The Niners gave up 23 to Seattle, 34 to Vegas and 20 to Washington in three of their last four. The Cowboys are better versions of all those. This is the lowest total of the week but it shouldn’t be. Back the Over on Sunday night. 

Cowboys vs. 49ers Moneyline Pick

The host 49ers are -195 on the moneyline, while Dallas is at +165. These have been two of my favorite teams to back this season and, unfortunately, I like them both again here. 

It’s why the spread is so enticing, but it also makes the moneyline less so. Dallas is where the value is, but going against a team on an 11-game winning streak, at home, is a risk. Still, if you’re going to pick a side, getting the Cowboys at this price isn’t terrible. 

Best Cowboys vs. 49ers Player Props

Dak Prescott, Over 250.5 Passing Yards

Odds: -110 at BetMGM

Prescott has gone for at least 256 yards in all but two games since Week 1. Sure the 49ers defense is good overall, but it ranks a highly suspect 27th in yards allowed to wide receivers. 

Dallas lives on big plays and San Fran ranked 30th the last three weeks in yards per attempt. Look for Prescott to build momentum off last week’s 305-yard, four-TD performance. 

Brock Purdy, Under 241.5 Pass Yards

Odds: -110 at Caesars

Purdy has eclipsed this total only twice in his six starts, and this is not a good matchup for him. The Cowboys rank No. 6 in the NFL in fewest yards allowed to tight ends and No. 8 in receiving yards to running backs – and just one total TD allowed between the two positions. 

That presumably limits the effects of George Kittle and Christian McCaffrey, who are averaging 7.5 receptions and 86.5 yards in Purdy’s six starts. 

About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been established as one of the nation's premier handicappers, specializing in the NFL where he's hit on more than 60% over the past three years. Adam's NBA, PGA and horse racing picks have also produced major winners over the last 12 months. His customized NFL and NBA odds for players and teams have been picked up by hundreds of websites over the past year.