Dak Prescott and the Dallas Cowboys aim to keep pace in the rugged NFC East when they host Matt Ryan and the Indianapolis Colts in the NFL Week 13 matchup for Sunday Night Football. 

The Cowboys (8-3) are in a great spot to qualify for the postseason and are hitting their stride at the right time, winners of two straight. The Colts (4-7-1), on the other hand, have dropped two in a row and are 2.5 games out of the AFC Playoff picture at the start of the week. 

RELATED: NFL Week 13 Picks, Predictions and Best Bets

Dallas is a sizeable 10.5-point favorite on NFL betting sites in the latest Colts vs. Cowboys odds, with the Over/Under set at a more-modest 44 points. 

Bookies.com NFL handicapper Adam Thompson – who is hitting on 63% of his NFL best bets the last six weeks – reveals his picks for the interconference primetime game. 

Colts vs. Cowboys Point Spread Pick

The Cowboys are -10.5 on betting apps, which is a big number, but five of the team’s last six wins were by 12 or more points. The offense is averaging 30.8 ppg over the last month. Indy’s defense is good but it could be missing players at each level. 

The bigger concern for backing Indy is the offense. The team shocked the Raiders 25-20 in Jeff Saturday’s first game coaching and Matt Ryan’s first game back under center. But since then it’s managed 16 and 17 points – which is one point more than they were averaging before the moves. Expect Dallas to score near 30 yet again and for the Colts to be unable to keep up. Dallas -11 is the play. 

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Colts vs. Cowboys Over/Under Best Bet

The 44-point Over/Under seems low for a game that features a team scoring nearly 31 ppg lately. But we’re considering the opponent. Don’t expect Dallas to get over 30 points, but don’t expect Indianapolis to do even close to that. 

The Under has hit in six of the last eight Cowboys home games, and is on an 8-1 run in Colts road contests. Trends have a way of evening out, but not here. Expect both teams to run first, then expect Dallas to keep running as it builds an advantage. Back the Under on Monday night. 

Colts vs. Cowboys Moneyline Pick

Dallas is -490 on the moneyline on betting sites, meaning it would take a wager of $490 to win $100 in profit. Conversely, Indianapolis is +390 (bet $100 to win $390 in profit). 

This is going to sound counterintuitive, but Indianapolis appears to be the better play here. We’re not expecting it, but a small wager could be used as a hedge in case something wild happens. Three of their last four losses were decided by one possession. Laying a small number on Colts +390 is worth considering. 

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Best Colts vs. Cowboys Player Props

Jonathan Taylor, Over 75.5 Rushing Yards

Odds: -115 at DraftKings

October 23 was the last time Taylor finished with under 76 rushing yards in a game. It’s the way the Colts stay in games and it’s not going to stop vs. the Cowboys. The more handoffs, the faster the clock, the less time Dak has the ball. Also, Dallas ranks No. 3 vs. the pass, but 24th vs. the run, allowing 132 yards per game. Its 4.7 yards per carry allowed is 25th. Feed JT. 

Matt Ryan, Throw An INT

Odds: -160 at BetMGM

In 10 games, Ryan has 10 INTs, tossing a pick in 60% of the games he’s started. These odds aren’t full of value, but here’s what makes me believe that 60% number seems likely to rise. Through the first seven games, Ryan’s QB rating when pressured was a ghastly 32.7, with a league-high 10 turnover-worthy plays.

The Cowboys rank No. 1 in the NFL in QB pressures, causing havoc on over 30% of dropbacks. Ryan is going to make a few INT-worthy decisions. Dallas should convert one of them. 

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