Arguably the best game of the week will feature the undefeated Arizona Cardinals traveling to Cleveland to take on the Browns. Not only do both teams have playoff aspirations, they each view themselves as Super Bowl contenders.

Can the Cardinals go on the road and beat the Browns in their stadium? Can Cleveland bounce back after a thrilling loss to the Chargers in Los Angeles? This contest should be a lot of fun and will tell us a lot about both teams.

To get you ready for this big-time matchup, here is everything you need to know from an NFL betting perspective going into Week 6.

Take a look at Browns vs Cardinals odds, injury report, betting lines and more.

Cardinals vs. Browns Key Matchups

Cardinals WR DeAndre Hopkins vs. Browns CB Denzel Ward: This is best on best. Hopkins is having another great season and it will be up to Ward to try to slow him down.

Browns RB Nick Chubb vs. Cardinals LB Zaven Collins: Chubb remains the most efficient running back in the NFL. Can Collins and Isaiah Simmons keep him from dominating this game? Probably not.

Browns LT Jedrick Wills vs. Cardinals DE Chandler Jones: Jones has been held in check since his 5-sack Week 1 performance. But he could have a big day in Week 6 as the offensive line for the Browns is banged up.

RELATED: NFL Week 6 Odds For All Games On The Schedule

Cardinals vs. Browns Key Stats

187: The Browns average the most rushing yards per game (187 YPG) in the NFL.

128: The Cardinals allow the fifth-most rushing yards per game in the NFL (128 YPG).

6: The Browns have won five of their last six home games.

5 of 7: The Under has hit in five of the last seven games for the Cardinals.

6-0: The Browns are 6-0 ATS in their last six games against NFC opponents.

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Cardinals vs. Browns Moneyline

The Cardinals are 5-0 this season, but their last two wins have been highly impressive. They’ve defeated two good divisional opponents in the Rams and the 49ers. So what is different about this Arizona team compared to years past?

They have a defense that can actually get stops. With Chandler Jones and J.J. Watt on the defensive line, they make it nearly impossible for teams to pass on them.

The Browns have some major issues on the offensive line right now as they could be without their top three offensive tackles in this game. While it might not impact them on the ground, it could really hurt Baker Mayfield when he drops back to throw.

Considering the value, the Cardinals (+130) on DraftKings are a great bet in Week 6.

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Cardinals vs. Browns Point Spread

If you're planning wagers at Arizona sports betting sites and the moneyline makes you nervous, consider the point spread instead. This game feels very much like a tossup game, which makes betting the Cardinals even easier.

Arizona is getting a field goal in this game despite the much better record. Plus, they are far healthier than the Browns and their quarterback is playing at an MVP level. It’s one of the most confusing NFL spreads as this game feels more like a “pick’em” than Browns -3.

Be sure to shop around for the best line on your betting apps and sportsbooks as this line has shifted all week long. Take the Cardinals +3 (-110) on FanDuel but expect them to win outright.

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Cardinals vs. Browns Totals

The total for this game is set at 50 on BetMGM, which feels low considering how good each offense has been this season. The Cardinals rank fourth in points per game while the Browns rank sixth.

Both teams are averaging well over 28 points per game, but Arizona’s defense has really shut opponents down this season. With the Browns likely to utilize their rushing attack to protect Baker Mayfield and their defense, this could be a slow-paced game in Cleveland.

For that reason, the under feels like the better bet here, albeit less fun. Take the Under 50 (-110) on BetMGM and expect a 24-23 type of game in Cleveland.

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