Carolina Panthers at Arizona Cardinals Picks & Betting Predictions

When assessing the NFL betting choices for Sunday’s Arizona Cardinals-Carolina Panthers game, a good place to start is the respective injury reports.

The 8-1 Cardinals were missing quarterback Kyler Murray and receivers DeAndre Hopkins and AJ Green in Week 9. However, they didn’t miss a beat in toppling the 49ers with Colt McCoy under center. Murray and Hopkins are expected back this week. On the other hand, running back Chase Edmonds (high ankle sprain) won’t play.

For the 4-5 Panthers, a once-promising 3-0 start to the season seems a long-ago memory. QB Sam Darnold will undergo an MRI on his shoulder this week. Defensive lineman Brian Burns (ankle) is an uncertain starter and center Matt Paradis (ACL tear) is out. At NFL betting sites the Cardinals are 9.5-point home favorites.

Take a look at Cardinals vs. Panthers odds, injury report, betting lines and more.

Panthers vs Cardinals Key Matchups

Panthers Offensive Line vs Cardinals Defensive Front: Along with Paridis, tackle Cameron Erving is also out for Carolina. That’s 40% of the starting offensive line missing against an Arizona pass rush that sacked the QB five times in last week’s win over the 49ers.

Darnold vs His Demons: The old New York Jets version of Darnold has resurfaced and it’s not pretty. He’s thrown 7 TDs against 11 interceptions during Carolina’s 1-5 skid. Darnold was benched against the New York Giants. If he can’t go because of his shoulder, XFL star PJ Walker gets the start.

Arizona Offense vs Carolina Defense: It’s the old story of the irresistible force facing the immovable object. The Cardinals are the NFL’s No. 2 offense. The Panthers are the league’s No. 3 defense.

RELATED: NFL Week 10 Odds & Betting Lines For All Games

5 Key Panthers vs Cardinals Stats

65: Number of penalties assessed to the Panthers. That’s the most of any NFL team.

15: Amount of times the Cardinals have rushed for 150+ yards under coach Kliff Kingsbury (since 2019).

1: Total TDs scored by the Carolina offense in their last 36 possessions.

7: Number of games in which the Cardinals have scored 30+ points this season.

0-15: Panthers’ record since 2020 when allowing 22 or more points in a game

Panthers vs Cardinals Weather Forecast

The weather forecast for Sunday afternoon at State Farm Stadium is picture-perfect Arizona desert conditions. There will be clear skies above, negligible wind at 1 mph and a game-time temperature of 78 degrees. The Panthers are 3-1 straight up and against the spread in their last four games in the Pacific Time Zone.

Panthers vs Cardinals Player Props

Panthers QB PJ Walker, Under 207.5 Passing Yards

Odds: -115 at DraftKings

Hard to imagine Walker lighting it up against the NFL’s best team.

Arizona Defense Anytime TD

Odds: +400 at DraftKings

An XFL refugee making his second NFL start against the opportunistic Cardinals defense screams pick-six.

Bet $5, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 74 Times Today

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK.

Panthers RB Christian McCaffrey, Over 62.5 Rushing Yards

Odds: -120 at DraftKings

With backup QB Walker at the helm, expect Carolina to go with a conservative gameplan.

RELATED: NFL Week 10 Picks & Best Bets For Every Game

Panthers vs Cardinals Moneyline

The Cardinals are just a couple of missteps away from being 9-0 on the season. Arizona’s only loss this season was at home. Carolina is actually a better team on the road this season. The Panthers are 2-2 away from home. Carolina won 31-21 last season at Arizona during Week 4 of the regular season.

Overall, the Panthers have won five in a row against the Cardinals. Carolina is 5-2 all-time at Arizona. However, this Carolina team looks to be in utter disarray. The Panthers are 1-2 against teams with winning records. It might be tempting to take the Panthers at +330 in the NFL picks. But don’t do it. In fact, pass on moneyline wagering.

Bet $1, Double Your Winnings Your Next 10 Bets Promo Code: BOOKIESDYW

Tap for Promo Activated! Visit site

Used 69 Times Today

Must be 21+ to participate. T&Cs apply.

Panthers vs Cardinals Point Spread

Laying 9.5 points in the NFL spreads, as sportsbooks are offering on the Cardinals, is a lot of points. The last four times the Panthers were an underdog of 9.5 or more points, they went 3-1 against the spread. They’re also 5-0 ATS in the last five games against the Cardinals.

This season, though, the Panthers are 1-5 ATS in the last six games. These aren’t the Panthers of recent vintage. Arizona is 6-1 ATS over the past seven games. Lay the 9.5 points at DraftKings and go with the Cards.

Bet $5, Get $200 in Bonus Bets Instantly

Tap for Promo Activated! Visit site

Used 77 Times Today

GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/18/25 at 11:59 PM ET. Sponsored by DK.

Panthers vs Cardinals Totals

Almost every analytic on the Carolina side of the ledger is suggesting that bettors go with the under on NFL betting apps. The total has gone under in five of the last six road games played by the Panthers. As well, the under’s been the correct play in 10 of Carolina’s last 12, and four of the past five games.

Everything on the Arizona side of this equation is suggesting to go with the over. They’ve gone over in 12 of the Cardinals’ last 15 games against NFC South opposition. Most significantly, the total’s gone over in four of the past five Cardinals-Panthers games. And it’s set at 44.5. That’s remarkably low for an Arizona game. Bet the over and take Over 44.5 (-110) at BetMGM.

$1,500 Paid Back in Bonus Bets If You Don't Win Promo Code: BOOKIES

Tap for Promo Activated! Visit site

Used 48 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate. Gambling problem? Call 1-800-GAMBLER (CO, DC, IL, IN, KY, LA, MD, MS, NC, NJ, OH, PA, TN, VA, WV, WY) Call 877-8-HOPENY or text HOPENY (467369) (NY). Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.