The San Francisco 49ers come off their bye week looking to turn around a losing streak as they host the resurgent Indianapolis Colts on Sunday Night Football for Week 7. The Niners (2-3) dropped three in a row before getting Week 6 off, while the Colts (2-4) have won two of three, with the one loss at Baltimore in overtime. Jimmy Garoppolo is expected back under center for the 49ers.

Betting sites and most betting apps have San Francisco at -4 in the latest Colts vs. 49ers NFL spreads range, though the line opened at -5.5.

Check out the latest Colts vs. 49ers odds ahead of the matchup on Sunday Night Football.

Colts vs. 49ers Key Matchups

Ross Dwelley vs. Colts Defense: The Colts rank 29th in TDs allowed to tight ends this season, not to mention 26th in receptions and 24th in yards. George Kittle is out, so Dwelley is the player to take advantage.

Jonathan Taylor vs. 49ers LBs: Taylor has broken out lately and is averaging a solid 113.7 yards from scrimmage per game. The Niners are averaging 121.4 yards allowed to RBs.

Deebo Samuel vs. Indy Secondary: Samuel, the Niners’ top WR, has had two games with at least eight receptions and at least 156 yards, and two others with five or fewer catches and under 60 yards. Indy ranks 16th in yards allowed to WRs but dead-last in TDs allowed.

RELATED: NFL Week 7 Odds & Betting Lines For All Games

5 Key Colts vs. 49ers Stats

1: Interception by the 49ers defense through five games. Carson Wentz has thrown just one pick through six games.

15: Passing TDs allowed by the Colts defense; only Washington has allowed more. Garoppolo has just one TD in three of his four games, and two in the other.

18.5: The percent success rate over the last 28 games for the 49ers, against the spread, as a home favorite. They’re 5-22-1 in that span.

31.3: The average yards in penalties difference between Indy and San Fran. The Colts rank No. 2 in fewest penalty yards (41.3) while the 49ers rank 31st (72.6).

163.5: The average yards from scrimmage for Colts RB Jonathan Taylor the last two weeks. He’s gained 169 and 158, while adding two TDs in each game.

Colts vs. 49ers Weather Forecast

Sunday night in San Francisco is the third day in a seven-day stretch in which rain is in the forecast, to some extent. Temperatures for Sunday Night Football are expected to be steady in the 50s with rain chances of 50% for game-time precipitation. During the day, sustained winds of up to 30 mph will hopefully have come and gone.

Colts vs. 49ers Player Props

Elijah Mitchell, Over 1.5 Receptions

Odds: -120 at DraftKings

Mitchell has just four receptions this season, two of which were in the Niners’ last game helmed by Trey Lance. Jimmy Garoppolo has favored fullback Kyle Juszczyk in the pass game more, but Mitchell has established himself as the top back. He can steal the pass targets from Trey Sermon and get two (or more) again here.

Jimmy Garoppolo, Over 204.5 Pass Yards

Odds: -115 at DraftKings

Garoppolo averages over 231 pass yards per game, though inconsistency has been an issue with two under-200 games and two well above that mark. Beating Indy requires passing; opponents who throw for more than 230 yards are 3-0 vs. Indy, and 1-2 when they don’t.

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Carson Wentz, Over 1.5 Touchdowns

Odds: +150 at DraftKings

The 49ers rank seventh in pass yards allowed, but they’re also allowing 1.6 TDs through the air per game. Wentz has found his rhythm with these Colts, throwing for two TDs in each of the last three games.

Jonathan Taylor, 50 Rushing Yards and a TD

Odds: +137 at FOX Bet

After failing to score in the Colts’ first three games, Taylor has a ridiculous nine touchdowns in the last three games. He’s become an irreplaceable part of the Indy offense, on the ground and through the air. He hasn’t rushed for under 50 yards in a game this season. Let’s combine the two for plus odds.

Mohamed Sanu, Longest Reception Under 13.5 Yards

Odds: -105 at BetMGM

Sanu is on the field for roughly half of the 49ers’ snaps, and is averaging two receptions and 9.7 yards for each. On the year, he has just one reception longer than 13 yards – and it went for 16. The Colts are allowing 10.9 yards per catch to everyone this season, 13.1 to receivers.

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RELATED: NFL Week 7 Picks & Best Bets For Every Game

Colts vs. 49ers Moneyline

When it comes to NFL betting on the moneyline, the question mark at QB for the 49ers is pushing money toward the Colts. Indy is still +165 on the moneyline, while San Francisco is set at -195.

One can argue the 49ers haven’t played their best ball yet, that they’ve underachieved and the bye week came at a good time. But right now, Indy is the better team. For value, look no further than Indy at those odds. You can get the Colts at DraftKings here.

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Colts vs. 49ers Point Spread

The 49ers are favored by 4 points after opening at -5.5, meaning the money is backing Indianapolis. With San Francisco on a bye last week, the move is likely due to the improved play of the Colts. Indy took care of the Dolphins and Texans with ease, and should have beaten a strong Ravens squad before letting them off the hook in an OT Baltimore win.

These teams are too close to break apart. While the San Fran defense is better, the Indy offense has been better lately. The Niners are giving points for being at home, but they’re 0-2 in front of their own fans. When it comes to the point spread, the Colts and the points has more value. You can get the Colts +3.5 (-110) at BetMGM.

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Colts vs. 49ers Totals

NFL sportsbooks have posted an Over/Under of 45.5 points for Week 7 Sunday Night Football. It likely wasn’t too tough for oddsmakers to set; combined, these teams average 46.5 ppg and allow 45.6 ppg.

The Over has been the best bet for most Colts games lately. The Over is 5-1 in Indy’s last six road games and 5-2 in the last seven as the underdog. The Under has led the way lately for Niners games, but Garoppolo is expected back. In his four games before getting hurt, three of them totaled 49 or more points. I’ll stay clear of this total, but prefer the Over if I’m looking to add a prime-time total side to my NFL picks for Week 7.

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