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Denver Broncos vs San Francisco 49ers Odds, Best Bets & Picks

Adam Thompson for Bookies.com

Adam Thompson  | 6 mins

Denver Broncos vs San Francisco 49ers Odds, Best Bets & Picks

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Questions on offense highlight a Sunday Night Football clash of playoff contenders, as Jimmy Garoppolo and the San Francisco 49ers head to the Rockies to face Russell Wilson and the Denver Broncos. 

Garoppolo, who guided the Niners to two NFC Championship games and one Super Bowl berth, gets his first start since being benched this offseason for second-year QB Trey Lance. Lance (ankle) was lost for the season in Week 2. 

Wilson’s Broncos have yet to showcase the firepower expected when the team went all-in on a trade for the former Seahawks star. Denver has scored 16 points in both games so far. 

Oddsmakers on NFL betting sites favor San Francisco, who are at -1.5 on the spread in the latest 49ers vs. Broncos odds. The Over/Under is 45 points. Denver is +1.5 and even on the moneyline on betting apps

Bookies.com NFL handicapper Adam Thompson – who has hit on a whopping 62-64% of his NFL picks three years running – reveals his Broncos vs. 49ers best bets for the showdown at Empower Field at Mile High. 

49ers vs. Broncos Point Spread Picks

The Niners’ Super Bowl odds actually improved when their starting QB was lost for the season. Lance may have the higher upside, but the steady Garoppolo may be just what is needed to complement arguably the NFL’s toughest defense. 

The Broncos will get better with Wilson under center, but zero preseason action and a brand-new head coach steering the ship is providing growing pains. WR Jerry Jeudy and standout CB Patrick Surtain are both likely to miss this one – and the hopeful return of TE George Kittle pushes the advantage to the Niners, regardless of game location. It’s not our favorite play, but those looking to pick a side against the spread should lean 49ers for their best bets.

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49ers vs. Broncos Over/Under Picks

The Over/Under of 45 at top sportsbooks suggests an expected boost in offense for two sides that have potential but haven’t found rhythm so far this season. This may not be the game to expect such a breakthrough. For either team. 

It’s only been two games, but so far the Broncos rank No. 5 against both the run and the pass, and No. 3 in overall yards allowed. And that’s nothing compared to the 49ers, who are No. 2 and No. 1 vs. the run and pass, respectively. Combined, they’ve allowed just 43 points all year. The Under has hit in San Francisco’s last five games, including the last four on the road, and in Denver’s last six in September. The Under is the best bet for Sunday Night Football between the Broncos and 49ers. 


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49ers vs. Broncos Moneyline Picks

This game is tough to call, and the moneyline NFL odds back up that argument. San Francisco is a manageable -120 road favorite, while Denver is at even-money +100. 

Matchups across the board don’t show many advantages for either side. Each defense has dominated, and the offenses are figuring things out. Injury concerns offer an incentive to back the 49ers at -120 for your Broncos vs. 49ers best bets. 

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Best 49ers vs. Broncos Player Props

Deebo Samuel, Over 55.5 Receiving Yards

Odds: -120 at Caesars Sportsbook

Samuel has 52 and 53 yards rushing in the 49ers’ two games, getting eight carries in the opener and four in Week 2. He instead got the ball more in the pass game with Garoppolo back under center. 

Expect more of that in Week 3. Last year, Samuel got over 32 rushing yards once over the last four games, but averaged 94.3 receiving yards. He has only 58 receiving through two games. That number is about to go up with Jimmy G. Get the best odds for this prop at Caesars. 

Brandon McManus, Over 6.5 Points

Odds: -115 at DraftKings

As the Broncos offense has fizzled, it’s been McManus that has stepped up his game. He’s hit three field goals and one extra point in each game, 10 points for each. The lone miss was a 64-yarder at Seattle. 

Denver ranks seventh in total yards, yet dead-last in red zone success. Don’t expect a huge change of fortunes against the NFL’s top-ranked defense. Lock in the Over at DraftKings. 

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About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been established as one of the nation's premier handicappers, specializing in the NFL where he's hit on more than 60% over the past three years. Adam's NBA, PGA and horse racing picks have also produced major winners over the last 12 months. His customized NFL and NBA odds for players and teams have been picked up by hundreds of websites over the past year.