One of the biggest games of the week features two AFC teams competing for a Wild Card berth in the conference. The Raiders are coming off back-to-back wins and control their own destiny in the AFC. If they win their final two games, they are in the playoffs. They’ll take on the red-hot Colts, who likely just need one more win to make the tournament. But can the Colts battle through their COVID-19 issues and get a win against a tough Las Vegas team?

To get you ready for this AFC matchup, here is everything you need to know from an NFL betting perspective along with our NFL picks going into Week 17.

Check out the latest Colts vs Raiders odds, betting lines, injury report and more.

Raiders vs. Colts Matchups

Colts LT Eric Fisher vs. Raiders DE Yannick Ngakoue: Fisher is dealing with multiple injuries and there is a chance he doesn’t play in Week 17. But if he does, look for him to see a ton of Ngakoue on the left side. The winner of this matchup will likely decide the game.

Colts WR Michael Pittman Jr. vs. Raiders CB Casey Hayward Jr.: Pittman is the leading receiver for the Colts and he will have a significant size advantage against Hayward. However, that has never bothered Hayward in the past. Assuming Hayward can clear COVID-19 protocols, this should be a fantastic battle on the outside.

Raiders WR Hunter Renfrow vs. Colts CB Kenny Moore II: Renfrow has been one of the league’s best slot receivers this season, but Moore has been the most dominant slot cornerback in the NFL for several years. This matchup should be a ton of fun to watch.

RELATED: NFL Week 17 odds & Betting Lines For All Games

Raiders vs. Colts Stats

21.1: The Raiders have the No. 17 scoring offense in the NFL, scoring only 21.1 PPG.

28.0: The Colts have the No. 5 scoring offense in the NFL, averaging 28 PPG.

6-1: The Colts are 6-1 in their last seven games straight up.

3-7: The Raiders are 3-7 ATS in their last ten games when playing on the road.

4-1: The Colts are 4-1 ATS in their last five games against AFC opponents.

Raiders vs. Colts Moneyline

If both teams were completely healthy, this game might be a blowout in favor of the Colts. They just have the far better roster and have played much better over the last month. But with the uncertainly at quarterback and offensive line for the Colts, this game is no longer a lock. The Colts are still -290 favorites at most sportsbooks, but there is no way you can bet on them at that price given that nearly 20 players are on the COVID-19 list.

If Carson Wentz and several starting offensive linemen return to the lineup before kickoff, that is when it’s okay to consider betting on Indianapolis on the moneyline. But until then, stay far away from the moneyline.

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Raiders vs. Colts Point Spread

Going into the week, the Colts were -7.5 point favorites over the Raiders on betting sites. That line moved to Colts -1 once it was announced that Carson Wentz had tested positive for COVID-19. However, with the changes to the reserve/COVID-19 list, it’s possible that Wentz could play on Sunday if he doesn’t show symptoms on Friday or Saturday.

That line has since moved back up to Colts -6.5 as sportsbooks and betting apps are assuming that Wentz will be on the field. Still, that feels like too many points as the Raiders are the far healthier team. Expect the Colts to win, but take the Raiders +6.5 (-110) on DraftKings.

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Raiders vs. Colts Totals

Much like the point spread, this is a line that has moved a ton over the week. It started at 46.5 at most sportsbooks, but dropped down to 41.5 after the Wentz news. Since then it’s climbed back up to 44.5. That still feels high as the Raiders are averaging only 16.6 points per game in their last eight contests.

Take the Under 44.5 (-110) on FanDuel and expect a low-scoring game as both teams try to run the ball and lean on their defense to win. A final score of 20-17 feels very likely in this playoff-like game.

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