• Bookies
  • NFL
  • NFL Picks
  • Sunday NFL Picks & Week 6 Predictions: 5 Must-Bets To Make Today
Most Valuable Offer

$1,000 First Bet on Caesars

Visit site
Must be 21+ to participate. T&Cs apply.

Sunday NFL Picks & Week 6 Predictions: 5 Must-Bets To Make Today

Adam Thompson for Bookies.com

Adam Thompson  | 7 mins

Sunday NFL Picks & Week 6 Predictions: 5 Must-Bets To Make Today

$1,000 First Bet on Caesars

Visit site
Used 74 Times Today
Popular in Virginia
Must be 21+ to participate. T&Cs apply.

There is only one undefeated team, and just two winless squads heading into Week 6 of the 2021 NFL season. There may not be any zeroes in the standings by Sunday night.

Kyler Murray and the Arizona Cardinals are the lone unbeaten team left, but they are a road underdog against Baker Mayfield and the Cleveland Browns. On the other side, Trevor Lawrence and the Jacksonville Jaguars have an opportunity to get win No. 1 vs. the 1-4 Miami Dolphins in London. Jared Goff’s Detroit Lions have come oh-so-close on two occasions, with another shot here at home against Joe Burrow and the Cincinnati Bengals.

Bookies.com NFL betting handicapper Adam Thompson has hit on 62.5% of his best bets at sportsbooks in the 2021 NFL season and finished over 60% the last three seasons. He’s poured through the NFL odds to deliver you his five best bets for NFL Week 6 Sunday games.

Sunday NFL Week 6 Best Bets

RELATED: NFL Week 6 Odds & Our Free NFL Picks

Jaguars ATS over Dolphins

Despite the lack of results, Jacksonville is progressing and finding out their strengths (run game). Last week vs. the Titans they had a season-high in yards and a season-low in yards allowed. They’re getting three at betting sites, and this is an opponent to get over the hump.

The Dolphins have no discernable strengths, the defense has been a huge disappointment and the offense has a QB that won’t throw downfield or a reliable runner to take the pressure off. (Locked in at +3.5 at Caesars Sportsbook)

$1,000 First Bet on Caesars

Visit site
Used 72 Times Today
Must be 21+ to participate. T&Cs apply.

Colts ATS over Texans

The Colts hopefully learned a lesson in their Monday night collapse vs. the Ravens. This is only the second non-playoff team they’ll have faced. They beat the first by 10 points, and that was on the road (at Miami). Houston nearly won at home vs. the Patriots last week but blew it. That was their only loss with Davis Mills at QB that was by less than 10. Indy has the matchups here and should cover the big line set by betting apps. (Locked in at -9.5 at DraftKings)

Bet $5, Get $150 in Bonus Bets Instantly

Visit site
Used 6 Times Today
Must be 21+ to participate. T&Cs apply.

Washington ATS over Chiefs

Patrick Mahomes and the Chiefs are going to bounce out of this rough spot (20 points in two of their last three games). But the concern with KC is it hasn’t stopped anyone.

Every opponent has put up at least 30. KC’s number is always inflated; it’s covered the spread just three times in its last 16 games. Washington is unbeaten when it gains 400-plus yards of offense and winless when it doesn’t. The Chiefs have allowed at least 435 yards in all but one game. (Locked in at +7 at BetMGM)

Up to $1,500 in Bonus Bets if Your First Bet Loses
Promo Code: BOOKIES

Visit site
Used 34 Times Today
Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate. Gambling problem? Call 1-800-GAMBLER (CO, DC, IL, IN, KY, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY) Call 877-8-HOPENY or text HOPENY (467369) (NY). Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.

Browns ATS over Cardinals

Cleveland’s defense was smashed by Justin Herbert and the Chargers for 47 points, but the Browns offense went off for 42. It was just one of those games. This is still a team that ranks fifth in total offense and fourth on defense.

The Cardinals have strengths but their weaknesses are glaring, especially this week. They’re not good vs. the run, which obviously plays right into the hands of the Chubb/Hunt Express. (Locked in at -2.5 at FOXBet)

Broncos ATS over Raiders

It’s the first game for a new Raiders coach who was the special teams coordinator before Tuesday. Not all players may be on board and there’s little chance Vegas can be totally prepared. But they had issues regardless of the coach.

The once-dominant offense has scored 11.5 ppg the last two weeks and things don’t get easier here in Denver vs. the third-ranked Broncos D. The steady Denver team with Teddy Bridgewater should win and cover. (Locked in at -3.5 with FanDuel)

Bet $5, Get $150 in Bonus Bets

Visit site
Used 49 Times Today
Gambling Problem? Call 1-800-GAMBLER. Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ and present in select states. FanDuel is offering online sports wagering in Kansas under an agreement with Kansas Star Casino, LLC. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, KY, MI, NJ, OH, PA, IL, TN, VA, VT), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), visit www.mdgamblinghelp.org (MD), 1-800-522-4700 (WY), or visit www.1800gambler.net (WV).

About the Author

Adam Thompson for Bookies.com
Adam Thompson
NFL writer and expert Adam Thompson joined Bookies.com in 2019 after a successful run as senior handicapper for SportsLine and CBSSports.com. He's long been established as one of the nation's premier handicappers, specializing in the NFL where he's hit on more than 60% over the past three years. Adam's NBA, PGA and horse racing picks have also produced major winners over the last 12 months. His customized NFL and NBA odds for players and teams have been picked up by hundreds of websites over the past year.