By Adam Thompson | | 22 mins
NFL Preseason Odds, Moneylines & Point Spreads For Week 1 & Beyond
The 2022 NFL betting season won’t officially get under way until Sept. 8 with the NFL Kickoff Game. But the preseason action has already started, with the Las Vegas Raiders beating the Jacksonville Jaguars 27-11 in the NFL Hall of Fame Game in Canton, Ohio on Thursday.
The rest of the NFL hits the gridiron for the first time the following week, as fans get a glimpse at free agent additions and rookie draft picks getting their first taste of pro action.
Highlights include a battle for L.A. with the Chargers and Rams facing off, plus primetime matchups between the Packers and 49ers, and Russell Wilson in Broncos gear as Denver hosts the Dallas Cowboys.
NFL Preseason Week 1 Odds
Let's take a look at the latest NFL odds for Week 1 of the 2022 preseason. Don't forget to shop around the different sportsbooks for the best lines and promo codes before wagering. This table will be updated as more betting lines become available for NFL Week 1 preseason games.
Odds via DraftKings Sportsbook and accurate as of publication (Aug. 10, 2022).
New York Giants at New England Patriots, Aug. 11, 7 p.m. ET
The Giants are the one team that didn’t re-sign any players, instead going and adding 10 new players via free agency and up to 11 draft picks that could be on the two-deep depth chart by Week 1. Everyone associated with the Giants is excited to see edge rusher Kayvon Thibodeau, the No. 5 overall pick in the 2022 NFL Draft, and tackle Evan Neal, the No. 7 pick.
QB Mac Jones exceeded expectations in guiding New England to the postseason as a rookie. We may get to see his possible top target for 2022, WR DeVante Parker, in action for the first time since being traded from Miami to New England. New addition Jabrill Peppers joins Devin McCourty as one of the premier safety tandems in the league.
Tennessee Titans at Baltimore Ravens, Aug. 11, 7:30 p.m. ET
The Titans are replacing A.J. Brown and Julio Jones with Robert Woods (acquired from the Rams) and Treylon Burks (first-round pick from Arkansas), and they inked two solid tight ends, including Austin Hooper. This is the first chance for Ryan Tannehill to get real action with his new targets.
The Ravens would have made the playoffs last season if not for an injury to QB Lamar Jackson that cratered the team’s chances. He’s back for a squad that mostly held steady in the offseason, except for a big signing of safety Marcus Williams and a new D-line. All eyes in Ravens camp are on Lamar, who is heading into a contract year and expected to sign a monster deal. The Ravens are riding a 20-game preseason win streak heading into this clash. It's the longest winning run in NFL preseason history.
Atlanta Falcons at Detroit Lions, Aug. 12, 6 p.m. ET
Matt Ryan is out, Marcus Mariota is in for the Falcons, who signed 15 free agents, made two big trades and added massive extensions for OT Jake Matthews and DT Grady Jarrett. Mariota has former Raiders teammate Bryan Edwards to target, as well as first-round pick Drake London out of USC. We may also see some Desmond Ridder at quarterback, a third round pick by the Falcons out of Cincinnati.
Lions fans should be pumped to see what their first pick from the 2022 NFL Draft looks like in the silver and blue, especially after the recent premiere of Hard Knocks on HBO. Aidan Hutchinson of Michigan will line up on the edge, while fellow first-round pick Jameson Williams from Alabama should be a top target for Jared Goff. Williams (ACL) certainly won’t play here, but WR DJ Chark, an addition from the Jaguars, could.
Cleveland Browns at Jacksonville Jaguars, Aug. 12, 7 p.m. ET
No Baker Mayfield, but it’s possible Deshaun Watson could be eligible for the preseason. If not, Jacoby Brissett was brought on as under-center insurance, as was former Cardinals QB Josh Rosen. It will likely be Brissett here getting reps early. Browns fans also get to see the acquired Amari Cooper for the first time in his first action since being traded from Dallas.
This will be Jacksonville’s second preseason game as they opened the NFL preseason schedule against the Raiders in the Hall of Fame Game on Aug. 4, losing 27-11. The offense especially could use the extra work, as QB Trevor Lawrence is expected to get reps with new targets Zay Jones, Evan Engram and Christian Kirk, although the latter is dealing with a minor ankle injury. The Jags also have two new interior linemen and RB Travis Etienne is returning from a season-long injury.
Arizona Cardinals at Cincinnati Bengals, Aug 12, 7:30 p.m. ET
Ravens former WR1 Marquise Brown was acquired prior to the NFL Draft, giving Kyler Murray a top target heading into the season with DeAndre Hopkins sidelined through suspension. Everyone else was brought back, including RB James Conner and TE Zach Ertz on multi-year extensions. Colt McCoy is also returning; expect a big Colt presence for this one with Murray protected having inked his long-term extension to remain in the desert.
Cincy hits the field for the first time since shocking the world by representing the AFC in the Super Bowl. Joe Burrow will be shielded by three new O-linemen, a position of great importance and one that will be under the microscope starting here.
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New York Jets at Philadelphia Eagles, Aug. 12, 7:30 p.m. ET
Zach Wilson gets back on the field after a tumultuous rookie season, but he has far more help this time around. Rookie WR Garrett Wilson and rookie RB Breece Hall should each get first-team action from Day One, starting here. The loss of tackle Mekhi Becton was an early body-blow for the Jets. He could miss the entire season after fracturing his kneecap in camp.
Meanwhile, the Eagles may not have any rookies play regularly in Week 1 of the regular season. But they will have some new faces, led by WR A.J. Brown, who should be the top target for rising QB Jalen Hurts as Philly looks to get to the postseason for the fifth time in six seasons.
Green Bay Packers at San Francisco 49ers, Aug. 12, 8:30 p.m. ET
The Packers actually know Aaron Rodgers will be under center for 2022 though the likelihood of him playing much in the preseason isn’t high. So we should see more of Jordon Love, a possible trade target for teams still needing a QB. Whoever throws won’t have Davante Adams to find; instead, it’s Allen Lazard and Sammy Watkins as the top receiving targets. Second-round draft pick Christian Watson will not feature after undergoing knee surgery.
Trey Lance is seemingly the QB atop the depth chart, but high-priced veteran Jimmy Garoppolo remains on the roster, creating a preseason storyline in the Bay Area. The addition of CB Charvarius Ward was the top addition to a team that went 10-7 and made the playoffs for only the third time since 2013.
Carolina Panthers at Washington Commanders, Aug. 13, 1 p.m. ET
Baker Mayfield and Matt Corral could make their Panthers debuts in Washington. One was acquired via trade in July, the other was drafted in the third round, each hoping to challenge Sam Darnold for the incumbent QB spot. Don’t expect to see Christian McCaffrey, who has played 10 games in two years, get much preseason action.
Carson Wentz could make his debut here for his new team after being acquired in a trade with the Colts. He’ll get to match up with WR Terry McLaurin, who just signed a massive deal to remain in Washington, and Penn State product Jahan Dotson, who the Commanders used a first-round pick to bring in.
Kansas City Chiefs at Chicago Bears, Aug. 13, 1 p.m. ET
The Chiefs missed out on getting back to the Super Bowl and now Tyreek Hill is gone. But Patrick Mahomes is back and KC reloaded by signing JuJu Smith-Schuster and Marquez Valdes-Scantling, starters last year with the Steelers and Chiefs respectively. The Chiefs also get a first chance to see first-round picks George Karlaftis (DE) and Trent McDuffie (CB).
Justin Fields begins Year Two of his pro career with new receivers to target, including Byron Pringle from the Chiefs, N'Keal Harry from the Patriots and Equanimeous St. Brown from the Packers. Fields tossed just seven TDs in 12 games last year, but injury woe has already struck the new-look Bears WR corps, with Pringle struggling with a quad problem and recent trade acquisition Harry dealing with a high ankle sprain.
Indianapolis Colts at Buffalo Bills, Aug. 13, 4 p.m. ET
Matt Ryan could make his debut after a 14-year stint with the Falcons, one that included four Pro Bowls, an NFL MVP and Offensive Rookie of the Year honors. Indy fans also get to see rookie WR Alec Pierce for the first time; he presumably could be paired with Michael Pittman Jr. in the starting lineup right away.
Most online sportsbooks have the Bills as favorites in the latest Super Bowl 57 odds. The offense is stacked led by Josh Allen, and an already good defense could jump to great with the addition of All-Pro LB Von Miller. Don't expect to see much of Allen, with Case Keenum and Matt Barkley getting the reps.
Seattle Seahawks at Pittsburgh Steelers, Aug. 13, 7 p.m. ET
All eyes will be on Drew Lock this preseason after Seattle traded away future Hall of Famer Russell Wilson to the Broncos. He was 4-12 the last two seasons in Denver, but is in a real battle with last year’s backup, Geno Smith. The team also gets a first look at a couple of other immediate impact players acquired in the Wilson trade, TE Noah Fant and DT Shelby Harris.
All eyes are on the QB in the first action of the post-Ben Roethlisberger era in Pittsburgh. The Steelers signed former Bears starter Mitchell Trubisky then used a first-round pick on Kenny Pickett out of Pitt. Rookie WR George Pickens of Georgia could see his first action as he replaces JuJu Smith-Schuster. Early reports say Trubisky is winning the QB camp battle.
Miami Dolphins at Tampa Bay Buccaneers, Aug. 13, 7:30 p.m. ET
Starting QBs often don’t play in Week 1 of the preseason, which means the Dolphins should get a good look at Teddy Bridgewater, who went 7-7 as the Broncos’ starting QB last year. The real fun will be seeing a revamped rush attack with Chase Edmonds, Sony Michel, Raheem Mostert and Alec Ingold all new to the team.
Tampa’s biggest offseason move was getting Tom Brady back from retirement. But they were also able to keep RB Leonard Fournette and WR Chris Godwin while also re-signing C Ryan Jensen and CB Carlton Davis to extensions. This is the 33rd preseason meeting between Miami and Tampa Bay. The Bucs are among the preseason favorites to win Super Bowl 57 at +700 on betting apps. They signed Kyle Rudolph at TE to replace the retired Rob Gronkowski.
New Orleans Saints at Houston Texans, Aug. 13, 8 p.m. ET
Jameis Winston returns on a two-year deal but we’re likely to see more from Andy Dalton, signed this offseason. The Saints’ biggest move was spending $61.5M on new safeties Tyrann Mathieu and Marcus Maye to fix a 17th-ranked pass defense. We could see our first action from Ohio State WR Chris Olave in New Orleans black and gold but fellow receiver Michael Thomas will likely continue his rehab from a long-term ankle injury. Both have received glowing camp reports.
The Texans received a slew of draft picks for Deshaun Watson, and they should see what they have starting here at home. As many as four players drafted in the opening three rounds could start for Houston this season, including first-round CB Derek Stingley Jr.
Dallas Cowboys at Denver Broncos, Aug. 13, 9 p.m. ET
The Cowboys had one of the less-busy offseasons of any NFL team, resigning standouts such as WR Michael Gallup and DE DeMarcus Lawrence and two safeties, but not replacing WR Amari Cooper. Dallas remains favorites on NFL futures markets to win the NFC East after going 11-5 last season.
Russell Wilson should get his first action here. Most of the rest of the offseason was spent on improving the defense. Denver added three new linebackers and two new defensive linemen, including Cowboys star Randy Gregory.
Los Angeles Rams at Los Angeles Chargers, Aug. 13, 10 p.m. ET
Don’t expect much change for the Rams, hitting the field for the first time since taking the Super Bowl on their home field. Matthew Stafford, Cooper Kupp and Aaron Donald are back on massive extensions – it’s unlikely any of them see much preseason action, but new WR Allen Robinson and LB Bobby Wagner, also the recipients of big money, could get into the game.
The Chargers have Justin Herbert and an offense that should put up points. So L.A. improved the defense in the offseason, with LB Khalil Mack, DL Sebastian Joseph-Day and CB J.C. Jackson among the highlights.
Minnesota Vikings at Las Vegas Raiders, Aug. 14, 4:25 p.m. ET
Kirk Cousins is back and so are his top targets, including Dalvin Cook and Justin Jefferson. The big changes were made on the defensive side, including the addition of LBs Jordan Hicks and Za’Darius Smith, to shore up a defense that ranked bottom-six vs. the run and pass.
Derek Carr finally gets to throw to his longtime friend and former college teammate Davante Adams, the key acquisition this offseason for Las Vegas. The defense added several new contributors, led by Edge rusher Chandler Jones from Arizona.