Adam Thompson for

By Adam Thompson | | 16 mins

NFL Week 1 Odds, Lines and Analysis for All 16 NFL Games

NFL Week 1 Odds, Lines and Analysis for All 16 NFL Games

Up to $5,000 Risk-Free Bet Plus a FREE NFL Jersey - Promo Code: BOOKIESRF

Bet Now

For the seventh time in his Hall of Fame career, quarterback Tom Brady opens a new season as a defending Super Bowl champion. His Tampa Bay Buccaneers host the Dallas Cowboys on the opening night of the 2021 NFL season. The Thursday, Sept. 9 showdown offers the first action of a new 17-game, 18-week regular season.

Patrick Mahomes and the Kansas City Chiefs, who lost to Brady and the Bucs in Super Bowl 55, are preseason favorites in NFL futures to win the next edition, set for Feb. 13, 2022, in Los Angeles. Tampa Bay is No. 2 in those Super Bowl odds and the favorite to win the NFC.

CHECK OUT: NFL Week 2 Odds & Analysis For All 16 Games

Don’t think Week 1 matters? When you are scrolling through those matchups on your favorite sports betting app, consider that the eventual Super Bowl champion is 44-10-1 all-time in that season’s opening game. With that, let’s take a look at the NFL spreads for the opening week of the 2021 NFL season from the top sportsbooks.

Week 1 NFL Games

Odds Shortening
Odds Drifting
Best Odds
Click the Offer for Details
Week 1 Games
Bet %
- -
- -
- -
@Soldier Field - Chicago
@Lucas Oil Stadium - Indianapolis
@Tiaa Bank Field - Jacksonville
@Hard Rock Stadium - Miami
- -
@Heinz Field - Pittsburgh
- -
@Lincoln Financial Field - Philadelphia
@Bank of America Stadium - Charlotte, NC
- -
@Metlife Stadium - East Rutherford
- -
@Firstenergy Stadium - Cleveland, OH
You're viewing 10 out of 20 games

Bet $1 Get $200 NFL Special plus 20% Deposit Bonus up to $1,000

Bet Now

Thursday, Sept. 9

Dallas Cowboys (+8) at Tampa Bay Buccaneers, 8:20 p.m. ET

The Buccaneers bring back Brady for an encore of their title 2021 season. However, he’s not the only player they bring back – not by a long shot. Tampa Bay actually returns all 22 starters, the first time in more than 40 years the defending champion has done so (the 1977 Raiders were the last). That’s good news for a team that finished seventh in total offense and sixth in total defense.

Meanwhile, the new season couldn’t come quickly enough for the Cowboys, who lost star QB Dak Prescott in Week 5 to a season-ending ankle injury and slogged their way to a 6-10 record. Coach Mike McCarthy is a hot seat contender, but the team hopes it addressed its biggest need (a 31st-ranked run defense) by adding rookie LBs Micah Parsons and Kelvin Joseph with first- and second-round picks. The Cowboys went 0-4 in preseason, but Prescott didn't play. He's reportedly been great in practice and is expected to be under center Week 1 without limitations.

Take a look at Cowboys vs. Buccaneers odds, injury report, betting lines and more.

Sunday, Sept. 12

Seattle Seahawks (-2.5) at Indianapolis Colts, 1 p.m. ET

Carson Wentz makes his debut for the Colts, who found Philip Rivers’ replacement via the trade. Wentz had 16 TDs and a league-high 17 INTs for the Eagles last year, but Indy coach Frank Reich hopes to re-find the Wentz form from 2017, when they worked together and Carson had a 33/7 TD/INT ratio. The Colts ranked in the top 10 in both total offense and defense in 2020, so Wentz should have a great supporting cast, including RB Jonathan Taylor, who rushed for 1,169 yards and 11 TDs in his rookie campaign.

The Seahawks went 12-4 despite ranking in the bottom half of both offense and defense. That was due to the heroics of Russell Wilson, who led the team to a 7-3 mark in games decided by a TD or less. Wilson, along with RB Chris Carson and WRs DK Metcalf and Tyler Lockett form one of the top skill packages in the NFL.

Take a look at Colts vs. Seahawks odds, injury report, betting lines and more.


Risk Free Bet up to $1,000
To Claim: Click Bet Now

Bet Now

Jacksonville Jaguars (-2.5) at Houston Texans, 1 p.m. ET

No. 1 overall pick Trevor Lawrence opens the season with high individual expectations, but team success may be fleeting. Jacksonville went 1-5 last season thanks to a 31st-ranked defense. Lawrence gets an ideal Week 1 opponent, however; Houston ranked 30th last year and no longer has J.J. Watt. Betting sites still like them better than this Texans team.

Former Bills starter Tyrod Taylor gets the nod at QB over embattled Deshaun Watson. He may rely on a running game that has a plethora of options, with Mark Ingram, Phillip Lindsay and Rex Burkhead joining David Johnson. Whichever defense can make a stop should have a considerable edge.

Take a look at Texans vs. Jaguars odds, injury report, betting lines and more.

Philadelphia Eagles (+3) at Atlanta Falcons, 1 p.m. ET

Second-year QB Jalen Hurts gets the keys to the Eagles offense, at least to begin the season (the team traded for QB Gardner Minshew on Aug. 28). To add another big-time target, Philly drafted Heisman Trophy winning WR DeVonta Smith. There are just as many questions on the other side of the ball: The Eagles allowed 27 or more points nine times while scoring that many just twice (and lost in both instances).

Speaking of missed expectations, the Falcons won only four games in 2020, though they were more competitive than that record showed. Atlanta was a brutal 1-9 in games decided by a TD or less. Julio Jones is gone but Matt Ryan and the offense still have weapons, including budding star WR Calvin Ridley and rookie TE Kyle Pitts.

Take a look at Falcons vs. Eagles odds, injury report, betting lines and more.

Los Angeles Chargers (-1) at Washington Football Team, 1 p.m. ET

Justin Herbert set rookie records for the Chargers, who begins his sophomore pro season with new head coach Brandon Staley. L.A. ranked in the top 10 in offense and defense last year despite injuries dooming some efforts. It added left tackle anchor Rashawn Slater in the first round to give Herbert even more time.

Herbert and the offense will have hands full against a defense that ranked No. 2 in the NFL in yards allowed, led by Chase Young. Washington defied expectations by advancing to the playoffs on the grit and inspiration of QB Alex Smith. Smith is gone, but successful journeyman and playmaker Ryan Fitzpatrick takes over.

Take a look at Chargers vs. Washington odds, injury report, betting lines and more.


Bet $10 Win $200 If Your Team Scores a TD Plus Risk Free Bet up to $1,000 - Promo Code: BOOKIES

Bet Now

Pittsburgh Steelers (+6.5) at Buffalo Bills, 1 p.m. ET

Division champions face off in one of the marquee matchups of Week 1. The Bills, led by MVP runner-up Josh Allen, went 13-3 to snap Bill Belichick’s stranglehold on the AFC East. The Steelers went 12-4 to edge out the Ravens and Browns in the AFC North.

Buffalo ranked No. 2 in total offense and No. 3 in scoring, led by Allen who passed for 4,544 yards and 37 TDs and rushed for eight more scores. Stefon Diggs was brought over from Minnesota and was the next-level WR (1,535 yards) Allen needed. The Steelers were led by a defense that ranked No. 3 overall, led by T.J. Watt, who topped the NFL in sacks, QB hits and tackles for loss.

Take a look at Bills vs. Steelers odds, injury report, betting lines and more.

San Francisco 49ers (-7.5) at Detroit Lions, 1 p.m. ET

It’s a new era in Detroit, as Dan Campbell takes over as head coach and Jared Goff helms the offense after being traded for Matthew Stafford, who is now in Los Angeles. The Lions’ biggest issue was a defense that allowed more yards and points than anyone. The Lions used four draft picks in the opening four rounds on defensive players.

The Niners welcome a reboot after injuries decimated any hopes of a return trip to the Super Bowl. Jimmy Garoppolo will likely be under center in the opener, but first-round selection Trey Lance awaits. The San Fran defense ranked in the top 7 vs. both the run and pass, and 2019 NFL Defensive Rookie of the Year Nick Bosa is back to lead the unit.

Take a look at Lions vs. 49ers odds, injury report, betting lines and more.

Minnesota Vikings (-3.5) at Cincinnati Bengals, 1 p.m. ET

Joe Burrow returns from a season-ending knee injury. He had 13 TDs to just five INTs though the Bengals’ 2-7-1 mark in that span didn’t show the progress the offense made. They added another weapon in Burrow’s former LSU teammate, Ja’Marr Chase, and Joe Mixon is finally healthy in the backfield.

Minnesota had big expectations in 2020 but a 7-9 record and missed playoffs plunged the season into bust category. The offense ranked No. 4 and no less is expected with Kirk Cousins, Adam Thielen and Dalvin Cook in charge. The defense was bottom-10 vs. the pass and run but many prognostications have it jumping into the top 10.

Take a look at Bengals vs. Vikings odds, injury report, betting lines and more.


Up to $5,000 Risk-Free Bet Plus a FREE NFL Jersey - Promo Code: BOOKIESRF

Bet Now

New York Jets (+5.5) at Carolina Panthers, 1 p.m. ET

On April 5, the Jets traded starting QB and former No. 3 overall pick Sam Darnold to the Carolina Panthers. On May 12, the NFL schedule was announced, and this game helps get opening Sunday kicked off. Darnold gets to face his former team, which will have rookie Zach Wilson under center for his first pro game. Wilson, a statistical standout at BYU, was taken No. 2 overall in the 2021 NFL Draft.

QBs aside, both teams have other reasons for optimism. New York, which went 2-14 last year, overhauled last year’s dead-last offense, replacing over half its starting lineup. Carolina, which was 5-11, ranked between 16th and 21st in run offense and defense, and pass offense and defense – and that was mostly without star RB Christian McCaffrey, finally healed after playing just three games in 2020.

Take a look at Panthers vs. Jets odds, injury report, betting lines and more.

Arizona Cardinals (+3) at Tennessee Titans, 1 p.m. ET

It should be an electric offensive showdown in Nashville. Julio Jones joins last year’s No. 4 scoring offense. He and two-time rushing champion Derrick Henry make one of the premier RB/WR combos, perhaps of all-time. Tennessee went 11-5 last year despite a No. 28 overall defense. It might be more of the same for the Titans.

The Titans match up against dynamic dual-threat Kyler Murray, who has his own No. 1 in DeAndre Hopkins and a No. 2 looking for a fresh start in seven-time Pro Bowler A.J. Green. The Cardinals got a few offseason boosts, most notably three-time Defensive Player of the Year JJ Watt and first-round LB Zaven Collins. Arizona sports betting will be live in time for this one, which means a lot of action will be placed in the Grand Canyon State.

Take a look at Cardinals vs. Titans odds, injury report, betting lines and more.

Cleveland Browns (+6.5) at Kansas City Chiefs, 4:25 p.m. ET

Patrick Mahomes and the Chiefs had another record-setting season en route to a 14-2 2020 season. But the ultimate goal was missed in a thorough Super Bowl defeat at the hands of the Buccaneers. KC enters the new season as the Super Bowl betting favorite. Clyde Edwards-Helaire returns healthy after a banged-up second half of the season, adding firepower to an already tough-to-contain offense.

The Browns won’t sneak up on anyone this year. After finishing a disappointing 6-10 the previous season, Baker Mayfield and a refurbished supporting cast led Cleveland to an 11-5 mark and first playoff berth since 2002. The Browns’ stellar record was in spite of finishing 16th in total offense and 17th in defense.

Take a look at Browns vs. Chiefs odds, injury report, betting lines and more.


Two Risk-Free Bets up to $2,000 - Promo Code: BOOKIESB

Bet Now

Miami Dolphins (+3) at New England Patriots, 4:25 p.m. ET

The Patriots went 7-9 in their first year without Tom Brady, but no team added more pieces in an effort to get back on track. That includes nearly a half-dozen contributors who opted out prior to the 2020 season, free-agent additions TEs Hunter Henry and Jonnu Smith, two-time Pro Bowl Edge rusher Matt Judon and No. 1 draft pick QB Mac Jones, who will get the start after New England cut Cam Newton on Aug. 31.

Tua Tagovailoa is back for his second year with the Dolphins, who went 10-6 but just missed out on the postseason. Their offense and defense ranked 22nd and 20th, respectively, as the momentum-driven Dolphins only had five out of 16 games decided by a TD or less. Jaylen Waddle and Will Fuller were added to boost the pass offense.

Take a look at Dolphins vs. Patriots odds, injury report, betting lines and more.

Denver Broncos (-3) at New York Giants, 4:25 p.m. ET

Both the Broncos (5-11) and Giants (6-10) had disappointing 2020 seasons, but each has reason for immediate bouncebacks. Denver acquired Teddy Bridgewater to bring stability to the QB position, while the defense will get a boost from the return of LB Von Miller, who missed most of last season due to injury.

Speaking of returns, Giants RB Saquon Barkley played only two games in 2020. Daniel Jones will welcome a stable run game, in addition to Kenny Golladay, who had 65 catches and 11 TDs with the Lions in 2019. New York's defense ranked 12th in yards allowed in 2020. Denver strengthened its defense by adding Pro Bowl CB Kyle Fuller and using its first-round pick on Patrick Surtain, the nation’s top-rated corner.


$1,000 Risk-Free First Bet

Bet Now

Take a look at Broncos vs. Giants odds, injury report, betting lines and more.

Green Bay Packers (-4) vs. New Orleans Saints, 4:25 p.m. ET

This game was moved to Jacksonville due to the aftermath of Hurricane Ida, and the line jumped in Green Bay's favor. Aaron Rodgers is back for what may be his swan song in Green Bay. The Saints' final year with a legend was last year; Drew Brees officially retired following New Orleans’ 12-4 season. Jameis Winston, who led the NFL in passing yards in 2019 for the Buccaneers, helms the Saints' offense.

Each offense is a force to be reckoned with – the Packers still have RB Aaron Jones and WR Davante Adams; the Saints, RB Alvin Kamara. Each team also returns most contributors from a strong defense. The Saints return most of a defense that ranked No. 4. Same with the Packers, whose defense ranked No. 9.

Take a look at Packers vs. Saints odds, injury report, betting lines and more.

Chicago Bears (+7.5) at Los Angeles Rams, 8:20 p.m. ET

Andy Dalton will be QB1 in Week 1 for Chicago. He's likely a placeholder for rookie Justin Fields, who generally outplayed Dalton in the preseason. Regardless, the Bears will yet again be paced by a defense that last season ranked 11th in yards allowed. If the offense can start to hold its own, the team can rise from its 8-8 record in 2020.

The Rams have higher, more immediate goals. Matthew Stafford was acquired to lead a team that already had the NFL’s top-ranked defense. The hope is Stafford, who finally gets a strong supporting cast after years without it in Detroit, can get L.A. back to the Super Bowl – which happens to be at its home stadium.

Take a look at Bears vs. Rams odds, injury report, betting lines and more.

Monday, Sept. 13

Baltimore Ravens (-4) at Las Vegas Raiders, 8:15 p.m. ET

Lamar Jackson was a unanimous MVP in 2019, but his game fell back to earth last year. He threw for 400 fewer yards and rushed for 200 fewer, with 10 fewer TDs. Baltimore still ranked No. 1 in the NFL in rushing (and 32nd in passing), and the defense was No. 1 in fewest yards allowed. The addition of WRs Sammy Watkins, from the Chiefs, and Rashod Bateman in the first round of the NFL Draft, could shore up the top weakness to a team with Super Bowl hopes. Gus Edwards will be tasked with filling the shoes of second-year pro J.K. Dobbins, who was lost for the year (knee) in preseason.

The Raiders have been strong starters the past two seasons but lost five of seven last year and five of six the year prior to miss the playoffs. One more year of experience and the addition of free safety Trevon Moehrig to boost a questionable pass defense could be the difference. Week 1 will be a huge litmus test.

Take a look at Ravens vs. Raiders odds, injury report, betting lines and more.


Deposit $1000, Get a $1000 Risk Free Bet - Promo Code: BOOKIES1000

Bet Now

Opening Spreads vs Current Spreads

How have the Week 1 NFL spreads changed since they were released in the spring? Here are the opening and current NFL lines via DraftKings Sportsbook.

Game matchupOpening SpreadCurrent Spread
Dallas Cowboys at Tampa Bay BuccaneersBuccaneers -6Buccaneers -8
Philadelphia Eagles at Atlanta FalconsFalcons -3Falcons -3
Jacksonville Jaguars at Houston TexansJaguars -2Jaguars -2.5
LA Chargers at WashingtonWashington -1.5Chargers -1
Arizona Cardinals at Tennessee TitansTitans -2.5Titans -3
Seattle Seahawks at Indianapolis ColtsColts -1.5Seahawks -2.5
Pittsburgh Steelers at Buffalo BillsBills -4.5Bills -6.5
San Francisco 49ers at Detroit Lions49ers -6.549ers -7.5
Minnesota Vikings at Cincinnati BengalsVikings -2.5Vikings -3.5
New York Jets at Carolina PanthersPanthers -4.5Panthers -5.5
Green Bay Packers at New Orleans SaintsPackers -1Packers -4
Miami Dolphins at New England PatriotsPatriots -2.5Patriots -3
Denver Broncos at New York GiantsBroncos -1Broncos -3
Cleveland Browns at Kansas City ChiefsChiefs -6.5Chiefs -6.5
Chicago Bears at LA RamsRams -6Rams -7.5
Baltimore Ravens at Las Vegas RaidersRavens -4.5Ravens -4

Bet $1 Get $200 NFL Special plus 20% Deposit Bonus up to $1,000

Bet Now

About the Author

Adam Thompson for
Adam Thompson
NFL writer and expert Adam Thompson joined in 2019 after a successful run as senior handicapper for SportsLine and Previously the sports editor of the Green Bay Press-Gazette.