Thanksgiving is an NFL holiday, and 2024 offers juicy showdowns starting with the Detroit Lions hosting the Chicago Bears, followed by the Dallas Cowboys hosting the rival New York Giants, and capped off with a marquee matchup between the Miami Dolphins and Green Bay Packers at historic Lambeau Field. 

Bookies Plus handicappers Adam Thompson, Nick Whalen and Jim Coventry reveal their top plays for all the Thanksgiving NFL action. See all of their NFL Week 13 picks, plus picks for NFL, college football, NBA, college hoops, NHL and Premier League action at Bookies.com/picks. 

Thanksgiving NFL Betting Predictions

Bears vs. Lions Picks

Since the Bears changed offensive coordinators, Chicago lost to Green Bay on a missed field goal before taking the Vikings to overtime. Against a banged-up Detroit secondary, the Bears should be able to have success through the air. Of course, when the Lions have the ball, they should succeed on the ground, even if David Montgomery (shoulder) is limited or out. However, the Bears have one of the best pass defenses in the league. That could lead to Detroit scoring 24 or fewer points. In that scenario, the Bears can keep this game within 10 points. – Jim Coventry

NFL Pick: Bears +10.5

Bears vs. Lions Top Player Prop

DJ Moore

Since the Bears changed offensive coordinators, Moore has posted 62 and 106 yards. This week, he'll be facing a Lions defense that plays a high rate of man coverage combined with a high blitz rate. That should help Moore convert short passes into big yardage after the catch against a set of cornerbacks who are far from elite in coverage. In a game the Bears will need to score points, Moore will likely be targeted 7+ times. – Jim Coventry

NFL Odds: Over 55.5 Receiving Yards (-115) at ESPN Bet

Giants vs. Cowboys Picks

We saw what a Tommy DeVito-led Giants offense looked like in an ugly 30-7 loss to the Buccaneers. Things likely won’t get much better against a rejuvenated Cowboys defense and with a banged-up O-line trying to stop it. Dallas is playing with purpose and confidence, coming off an emotional win over the Commanders, while Giants players are playing like this season is over. – Bill Speros

Dolphins vs. Packers Picks

Tua Tagovailoa wants to end the stigma of the Dolphins and himself being unable to compete when it’s cold, but the stigma is there because it’s true. Tua is 1-5 ATS when it’s 50 or colder, Miami is 1-8 ATS when it’s 40 or under since 2017. Meanwhile, GB has won six of seven and its big-play offense is clicking in all phases. – Adam Thompson

NFL Pick: Packers -3

Dolphins vs. Packers  Top Players Prop

Tua Tagovailoa wants to end the stigma of the Dolphins and himself being unable to compete when it’s cold, but the stigma is there because it’s true. Tua is 1-5 ATS when it’s 50 or colder, Miami is 1-8 ATS when it’s 40 or under since 2017. Meanwhile, GB has won six of seven and its big-play offense is clicking in all phases. – Adam Thompson

Tucker Kraft

In 11 games, Kraft has gone Over this total in six of them. The Packers' tight end could be in line for a big evening at Lambeau Field. The Dolphins are elite at slowing wide receivers, forcing teams to incorporate TEs more. They allow six receptions to the position – only the Chiefs allow more – and 56.4 yards per game. – Adam Thompson

Jonnu Smith

NFL Odds: Over 30.5 Receiving Yards (-115)  at BetMGM

I know the elements are a big concern here for the Miami offense, but the Dolphins running game has struggled all season, so 25-degree-weather or not, they’re going to have to throw on the Green Bay defense. Smith has gone over this number in four straight — and six of his last seven — and the Packers’ defense has struggled against tight ends, allowing 8.4 yards per target and an 80.0% catch rate (third-highest in the NFL). – Nick Whalen

 NFL Odds: Over 41.5 Receiving Yards (-115) at DraftKings