The fourth and final grand slam of the WTA calendar – the US Open – gets underway in Queens, New York, starting on Monday, Aug. 29. The world’s best players will be fighting for the trophy and for the honor of winning a major title.

All eyes will be on tennis betting favorite and World No. 1 Iga Swiatek, as well as 23-time grand slam champion Serena Williams and defending champion Emma Raducanu (to name a few) as they get their bids underway.

Arguably, the women’s game has never been so deep as it is for this year’s US Open. So, with that in mind, we highlight some of the best bets currently trading with top-rated betting apps such as BetMGM, DraftKings Sportsbook, FanDuel and more.

2022 U.S. Open Women’s Odds

Odds via DraftKings and current as of publication.

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2022 U.S Open Women's Betting Predictions

Iga Swiatek

Odds: +450 at BetMGM

With a career-high ranking of No.1, six titles spanning two surfaces (hard and clay) in 2022, including a second-career French Open title, and a record-setting 37-game unbeaten run, Swiatek has earned the right to be THE player to beat at this year’s US Open. The 21-year-old didn’t have the best US Open warmup with early exits in Toronto and Cincinnati, but she’s got the quality to bounce back strong at Flushing Meadows.

Swiatek’s draw is littered with stumbling blocks, Former US Open champion Sloane Stephens looms as a potential R64 opponent. Later, she could face dangerous floaters such as Ekaterina Alexandrova, Amanda Anisimova, former Aussie Open champion Sofia Kenin and/or Jelena Ostapenko on her path to the quarterfinals. In the quarters, she could face any number of seeded threats, including an in-form Petra Kvitova or American Jessica Pegula.

RELATED: U.S Open Men's Odds, Betting Tips & Best Bets

Simona Halep

Odds: +800 at FanDuel

Halep’s top betting odds are underscored by her recent win in Toronto, beating Haddad-Maia in three sets. The two-time grand slam champion is seeking to win her first ever US Open title. She headlines a tough third quarter of the draw that is flanked by last year’s semifinalist Maria Sakkari – should the draw fall in line with the seeding, the pair would collide in the quarters.

However, before Halep can look that far ahead, she’ll need to overcome several dangerous floaters. No.30 seed Jil Teichmann looms as a potential third-round challenge while Americans Madison Keys or Coco Gauff could emerge as R16 opponents.

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Carolina Garcia

Odds: +1600 at bet365

Garcia is coming off a dream run in Cincinnati where she emerged from the qualifying round to win the coveted WTA 1000 title. Garcia falls into the third quarter of the draw as the 17th seed. She’s in the same section as Haddad-Maia and Sakkari.

The former could be a difficult third-round opponent while the latter is a potential R16 opponent. Other dangerous floaters in this section include former US Open champion Bianca Andreescu and American hopeful Alison Riske-Amritraj.

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Emma Raducanu

Odds: +2300 at FanDuel

A year after soaring to great heights following her historic US Open title, Raducanu has come back down to earth with a thud. Injuries and a bout of Covid-19 set the No.1 Briton back in the first half of the season and she hasn’t quite recovered since. In fact, her fitness is a worry. She comes into the US Open with a subpar 13-15 record. What’s more, she hasn’t been able to string together more than two wins in a row since the start of 2022.

Raducanu’s title defense begins against veteran Alize Cornet. If she survives that first-round encounter (big if), then she could face American Taylor Townsend or Katerina Siniakova in the R16. Then, four-time grand slam champion Naomi Osaka or American Danielle Collins in the R32. After that, the R16 could set up a match against Venus Williams, Aryna Sabalenka or Wimbledon champion Elena Rybakina, to name a few.

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Naomi Osaka

Odds: +2500 at BetMGM

It’s no secret that Osaka is playing nowhere near the level that saw her pick up four grand slam titles between 2018 and 2021. She comes into the US Open with a 1-3 record on the American hard-court swing, marked by losses to Gauff, Kaia Kanepi and Shuai Zhang.

There’s no doubt that Osaka can win another grand slam title, but it’s hard to see her accomplishing the feat over the next fortnight given her questionable form and relatively tough third quarter of the draw.

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Serena Williams

Odds: +5000 at Caesars Sportsbook

This is likely Serena Williams’ final appearance at the US Open and her last chance to match Margaret Court in the history books with 24 grand slam titles. The sentimentalists will be cheering her on, but the tennis odds are stacked against her. Williams’ form is questionable since returning to the tour at the Wimbledon Championships. She’s 1-3 in her last three tournaments, including a first-round exit to Raducanu in Cincy.

Having said that, Williams falls into the fourth quarter of the draw that is flanked by top seeds Anett Kontaveit and Ons Jabeur. Other seeds in this section include Leylah Fernandez, Daria Kasatkina and Veronika Kudermetova, to name a few. Of all the sections, this is arguably the most wide-open. Could Serena capitalize?

Best Americans To Bet

The top three American bets are Jessica Pegula, Amanda Anisimova and Coco Gauff. The first two fall into the first quarter of the draw and could cancel each other out. Gauff, meanwhile, is in a loaded third quarter. A lot would have to fall Gauff’s way to pave her path to the title.

Long-shot American Bets

The top three American long shots on betting sites are Madison Keys, Sloane Stephens and Shelby Rogers. Keys is in the same quarter are Gauff. Stephens has a nightmare draw with a potential R64 clash with Swiatek. Rogers, the runner-up at the Silicon Valley Classic, falls into the wide-open fourth quarter.

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