Best NFL Week 1 Betting Tips: How to Bet On the NFL at UK Betting Sites

By Mark Fordham Sep 3rd, 2025 12:18 PM EDT

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NFL fans in the UK can get ready to lose their Thursdays, Sundays and Mondays for a few months, as the 2025 season is here! With so many games each week, it can be easy to get lost when looking to place a bet on the NFL at top UK betting sites. That's why we have put together our experts' NFL betting tips to point you in the right direction.

We've got you covered with our NFL best bets, NFL bet builders, NFL acca tips and NFL player prop tips, with the best odds from UK betting sites. Keep reading for our best NFL betting tips for Week 1.

Best NFL Week 1 Betting Tips

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NFL Best Bets

Call it whatever you like - the NAP, the lock of the week, this week's banker. Every week, we'll pick out our best bet in the NFL. While our other selections will have juicier prices, our best bet will be the selection we're most confident in. With hundreds of markets to choose from at NFL betting sites, you'll be spoilt for choice. If you're having one bet on the NFL this week, this is what we would advise it should be.

Best NFL Betting Tip for Week 1

The Patriots struggled to score points last season, never really putting up the sort of performances worthy of the talent on the roster. However, with Josh McDaniels back as Offensive Coordinator we could see some life in the offense this season. They have been given a soft opening matchup against the Raiders and should have no trouble seeing off a team who are predicted to win fewer than half of their games this season.

Back the Patriots Half Time / Full Time at 8/5 with bet365

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21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

NFL Acca Tips

In any given week, there can be up to 16 games taking place in the NFL. That's a lot to get your head around at new betting sites. Every week, our team of experts will pick the best NFL acca tips. Most punters choose to do their NFL accas on moneyline, handicap and total points markets, but there's no limit to what you can choose. We advise choosing an acca insurance site to give yourself a chance of getting your stake back as a free bet if only one selection lets you down.

Best NFL Acca Tip - Week 1

So the saying goes: nothing is certain in life except death, taxes and the Colts losing their season opener. Indy haven’t won to start an NFL season for 12 years, and they probably won’t this season against the Dolphins. The Browns have three quarterbacks on their roster, and none of them are appealing options as they come up against a quietly confident Bengals even after their defensive disaster last season.

Aaron Rodgers swapped the Jets for the Steelers in the offseason, and here’s to hoping he can put on a show (or the Jets defense does) to secure the over when two relatively defensive-minded teams face each other. Spencer Rattler is really going to have to have improved greatly from Year 1 for the Saints to win many games and avoid him being replaced by rookie Tyler Shough. That improvement won’t come in Week 1.

Back Bengals ML, Dolphins ML, Cardinals -6.5 and Over 38.5 points in Pit vs NYJ at 177/20 with 10bet

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21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

NFL Bet Builder Tips

The NFL is always something to look out for when browsing the best bet builder sites. A lot of lines on NFL games are priced up as pick 'ems, which isn't much use for punters looking to back something at a bigger price. With NFL bet builders, you can combine multiple selections from a range of markets on the same game and combine them into one bet. Check out our best NFL bet builder tip below.

Best NFL Bet Builder Tip - Week 1

Two teams that are likely to improve on last season meet in Week 1 as the Carolina Panthers head south to face the Jacksonville Jaguars, and the visitors looks like strong value to keep it close. Although the NFC South side finished 5-12, they went 4-5 in an exceptionally tricky last nine weeks and were involved in seven one-score games during that stretch.

Adam Thielen has returned to Minnesota, but that only paves the way for Xavier Legette to improve as WR2 behind first-round pick Tetairoa McMillan. The eighth overall selection scored 26 touchdowns in three seasons in college and should benefit from the vast improvement that Bryce Young showed with his arm in the second half of last season.

The Jags should have no problem getting on the board themselves in the form of their own star receiver, Brian Thomas Jr, who recorded 1,282 receiving yards and 10 TDs in his debut year in 2024, and should feast on a Panthers team that gave up an average of 2.1 passing scores per game last season.

Back the Panthers +3.5, Brian Thomas Jr. and Tetairoa McMillan to score a touchdown at 7/1 with Betway

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21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

Best NFL Player Prop Bets

Player props have become one of the most popular NFL markets on betting apps. With these, you can back players to have over or under a set amount of yards, receptions, rushing attempts, tackles, sacks, interceptions or anything else you can think of. Some bookies on our list of betting sites also have player milestone betting, which offers higher lines and bigger odds as a result. Here's this week's best NFL player prop bet:

Best NFL Player Prop Tip - Week 1

Despite losing a lot more games than he won in his rookie season, Patriots quarterback Drake Maye showed some clear signs of promise. He did a lot of damage with his legs, picking up over 400 yards on the ground last season in only 10 starts.

His rushing lines throughout the season are likely to increase if he picks up from where he left off last season. With 30+ rushing yards in seven games last year, including a 95-yard game against the Titans and a 59-yard rushing performance against the Colts, we can expect more of the same in his second season.

Maye's line this week is set at 29.5, but we like the look of a milestone bet with BoyleSports. The Raiders don't appear to have the stingiest defence in the league, and that may well be something the Patriots can exploit.

Back Drake Maye 50+ rushing yards at 6/1 with BoyleSports

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21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

How to Bet on the NFL - Week 1

Our aim at Bookies.com is to give you everything you need in one place for betting on the NFL. On this page, we've provided our best NFL betting tips for the week, along with a list of new customer betting offers from top UK sites.

Once you have chosen your preferred betting site, click on the link on this page to be brought to the site. Doing this will link the welcome offer to your new account. Next, sign up by entering your details on the betting site, select a payment method and make your first deposit.

To place a bet, choose American football from the list of sports available. Go to the game you want to bet on and click on the odds beside your chosen selection. This will add it to a betslip, which will appear on the page. Enter your stake, confirm the bet and voila. All that's left to do is cheer your selection on and hopefully watch it win. Once your qualifying bet settles, you'll be eligible to receive any free bets that were part of the welcome offer.

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21+. New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, OH, PA, TN, VT, VA, WV, or WY. Must sign up by 9/30/25. Apply offer in bet slip; place $1+ American football cash wager w/ odds +300 or longer each Game Day. Wager must settle as loss to qualify for FanCash equal to the amount of losing wager (up to $100 FanCash per Game Day). Rewards expire 10/31/25. Terms, including FanCash terms apply-see Fanatics Sportsbook app. Gambling Problem? Call or Text 1-800-GAMBLER, 1-800-NEXT-STEP (AZ), 1-800-9-WITH-IT (IN), 1-888-532-3500 (VA).

About the Author

Mark Fordham

More About Mark

Mark spent over a decade as a sports reporter and editor with Goal.com and Bleacher Report. He is now a Content Editor at Bookies.com covering all manner of sports from the Premier League and cricket to the NBA and NFL, and is our resident EPL tipster. Mark also has years of experience working with all things online casino, and knows a good one from a bad one.

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