The Thanksgiving Day NFL betting menu begins with the Buffalo Bills coming back to Detroit to play their second game in the Motor City in four days. Last Sunday, the Bills beat the Browns in a game originally scheduled for Orchard Park, New York. It was moved because of a massive blizzard. 

Thursday afternoon, the Bills get the Detroit Lions. When both of these teams are at their best, they score a lot of points. Expect the same with each coming off a short week. This should make anytime touchdown prop bets more enjoyable and profitable. 

Here are our best anytime TD scorer prop bets on sports betting apps for the Bills-Lions game on Thanksgiving Day. Kickoff is scheduled for 12:30 p.m. ET on CBS. 

RELATED: Thanksgiving Day NFL Picks, Best Bets and Predictions

Best TD Scorer Prop Bets for Bills-Lions

Bills RB Devin Singletary Anytime TD

Odds: +125 at BetMGM

The Lions have won three straight. Their defense has forced six turnovers in those three wins. The Bills won’t try to force anything and instead just use the weight of their offense to wear down the Lions. Singletary rushed for a season-high 86 yards last week and ran for a score against the Browns. Look for a similar use of Singletary this week, and another trip into the end zone. 

Up to $1,500 in Bonus Bets if Your First Bet Loses Promo Code: BOOKIES

Tap for Promo Activated! Visit site

Used 48 Times Today

Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate & present in OH. In partnership with MGM Northfield Park. Gambling problem? Call 1-800-GAMBLER. Visit BetMGM.com for T&Cs. US promotional offers not available in NY, NV, or Puerto Rico.

Josh Allen Anytime TD

Josh Allen Anytime TD & Bills Win

Anytime TD Odds: +125 at BetMGM

Anytime TD Odds & Win: +130 at BetMGM

Josh Allen is not afraid to run the ball, especially in the Red Zone. The Lions will be laying off and going for the turnover, rather than playing tight man. Allen will have room to roam and sort of loves it. He’s as hard-nosed as they come. Allen has 159 combined passing and rushing TDs, that’s the 3^rd most for any QB in his first five years in NFL history. He’s run for 9 TDs in his past 21 road starts. And he ran for a score in Sunday’s “home” game at Detroit against the Browns. Look for Allen to end up in the end zone with the ball in this one.

RELATED: Week 12 NFL Picks, Best Bets And Odds For Sunday

Gabriel Davis First Bills TD

Odds: +550 at BetMGM

The Bills would love to strike early and fast. Davis is the perfect player to do just that. The Bills will stretch the Lions secondary and load up on Stefon Diggs. Davis has had 5+ catches and 65+ receiving yards in his past 2 games. Allen is comfortable with going deep to Davis, who can accelerate with the ball as well as anyone. One slip in the Lions secondary, and you’ll be cashing on this one. 

Bet $5, Get $150 Instantly

Tap for Promo Activated! Visit site

Used 55 Times Today

21+ and present in most states. (18+ DC/KY/NH/WY). Void in IA/KS/KY/LA/MD/MI/NJ/NY/TN/VA/VT/ONT. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). 1 per new customer. Min. $5 deposit. Min. $5 bet. Max. $150 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: dkng.co/bball. Ends 1/5/25 at 11:59 PM ET. Sponsored by DraftKings. GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD).

Jamaal Williams First Lions TD

Odds: +350 at BetMGM

There’s no reason to fight the tide on this one. Williams ran for 3 TDs in the Lions’ 31-18 smackdown of the New York Giants on Sunday at MetLife Stadium. He leads the NFL with 12 rushing scores this season. The Lions will do their best to keep Allen and the Bills off the field by running the ball and running clock. When/if they reach the Red Zone, Jared Goff will play it safe. Williams will be the go-to ball carrier for the Lions close to the end zone.