Your NFL Week 1 Complete Betting Guide

By Bookies.com | Aug 12th, 2025 12:02 PM EDT

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The NFL is back. Stretched out in front of us is glorious football action, week after week. It all starts on Thursday night when the Super Bowl champion Rams host the Bills.

And it continues on Sunday with our first main slate of action, including the Chiefs at the Cardinals and the new-look Raiders against the Chargers. Russell Wilson and his Denver Broncos wrap things up on Monday night when they visit Seattle. We can't wait.

To help get you ready for this football buffet, we've collected all our NFL betting content into one handy place for you. And that place is right here.

Each week, we'll update this article with all of our NFL content - including NFL picks, parlay bets to back, best player props, and more. So just bookmark this page and revisit it each week of the season to check in on our best picks and plays.

Everything You Need For NFL Week 1

Rams vs Bills Thursday Night Football

• Rams vs Bills Best Bets And Picks For 2022 NFL Kickoff Game

Week 1 NFL Picks & Betting Previews

• NFL Week 1 Best Bets, Predictions And Picks For All 16 Games
• NFL Week 1 Odds, Moneylines and Point Spreads
• Chiefs vs Cardinals Best Bets, Picks and Predictions
• Cowboys vs Buccanners Best Bets, Picks and Predictions for Sunday Night Football

NFL Week 1 Parlays

• Your Best Week 1 NFL Parlays To Back

NFL Week 1 Player Props

• Best NFL Player Prop Bets For Week 1

NFL Week 1 Teaser Bets

• Best NFL Week 1 Teaser Bets To Back

NFL Futures Bets To Back Now

• How To Bet The 8 Divisions Ahead of Week 1

Ranking Every NFL Starting Quarterback ATS

• Against the Spread Record For Every Starting QB in the NFL

Ranking Every NFL Head Coach ATS

• Against The Spread Record For Every Head Coach In the NFL

Super Bowl Odds Tracker

• Get the Latest Super Bowl Odds for All 32 Teams

NFC & AFC Conference Odds Tracker

• Get the Latest Conference Championship Odds for All 32 Teams

NFL Divisional Odds Tracker

• Get the Latest Divisional Odds For All 8 Divisions

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