The NFL betting season begins on Thursday, September 5 with a rematch of the AFC Championship Game. 

The two-time defending Super Bowl champion Kansas City Chiefs play host to the Baltimore Ravens. Both teams are expected to be stocked and reloaded for another deep run in the postseason. 

Taylor Swift’s never-ending Eras Tour takes a break from August until November. So Swifties should get their fill of T.S. throughout the first 10 weeks of the season. Expect Travis Kelce’s better half to be in attendance when the Chiefs raise their fourth Super Bowl championship banner. 

RELATED: Super Bowl 59 Odds

On Friday. September 6 – yes, we said Friday – the NFL plays its first-ever game in the Southern Hemisphere as the Philadelphia Eagles serve as the home team in Brazil against the Green Bay Packers. 

The national game of the week on Fox has the Dallas Cowboys visiting Cleveland. This one is notable because Tom Brady makes his debut as the network’s lead NFL in-game analyst. 

Monday night has the New York Jets at San Francisco. Aaron Rodgers will be making only his second start since 2022. Last season, he took just four snaps for the Jets before he was knocked out for the season with an injury. 

2024 NFL Week 1 Picks

Now it’s on to our Week 1 NFL picks to back on your favorite sports betting app. 

2024 NFL Week 1 Best Bets To Back Today

Thursday, September 5

Baltimore Ravens at Kansas City Chiefs, 8:20 p.m. (NBC)

Buzz: The Chiefs celebrate their second-straight Super Bowl title. Expect Taylor Swift to be in attendance along with a full house in Kansas City for this AFC Championship Game rematch.  The Chiefs opened the NFL season at home last year and lost to the Lions. The Ravens have seen multiple departures in free agency and on their coaching staff. But John Harbaugh has four months to prepare for this game. He’s 12-4 in Week 1 and is getting points. Lamar Jackson pocketed a 5-year, $260 million contract this offseason. He'll be fully healthy, something that’s always an issue in the postseason. And he’s 11-2 ATS as a starter as an underdog.

Best Bet: Ravens +3 (-110) with DraftKings Sportsbook

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Friday, September 6

Green Bay Packers vs. Philadelphia Eagles, 8:20 p.m. (Peacock)

Buzz: Jordan Love secured his job as the Packers franchise QB last season. He secured a 4-year, $220 million extension this offseason. Except the Packers offense to surprise here. Philadelphia has undergone some wholesale changes in the offseason. But the core of Jalen Hurts’ offense is still intact, including 4 of the 5 starters on the offensive line. It’s still a big ask for 48.5 points in a Week 1 game played on neutral turf in a foreign country after a long road trip for both teams. Viewers can begin their ranting now since the game will not be televised in the United States - outside of the Packers and Eagles home markets. It will streamed live via Peacock. 

Best Bet: Under 48.5 Points  (-110) with DraftKings Sportsbook

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Sunday, September 8

Pittsburgh Steelers at Atlanta Falcons, 1 p.m. (Fox)

Buzz: The Steelers and Falcons are two of the teams debuting new starting quarterbacks in Week 1. Rookies Michael Penix could go for the Falcons. Even after signing Kirk Cousins. That's been the big question in Atlanta since the NFL Draft. The Steelers acquired Russell Wilson in the offseason in a bid for some stability at the QB position to complement a stout defense. The Falcons are stacked with skill players, regardless of their QB. Both offenses in this game will still be in the "project" phase. We had the under here when the total opened at 43.5 points. It's now down to 40.5. That's too much of movement. We'll go with the road dog. 

Best Bet: Steelers +3 (-110) with DraftKings Sportsbook

Arizona Cardinals at Buffalo Bills, 1 p.m. (CBS)

Buzz: The Bills begin the post-Stefon Diggs Era at home. The Bills should enter the season stable and healthy. A welcomed change. The Cardinals have turned Kyler Murray and Marvin Harrison Jr. into the focus of their offense. This game is a big test for a Cardinals team that believes it can content for a playoff spot. An opening day road Eastern Time Zone start offers the most challenging of circumstances. The Bills underwent some major changes in the offseason. This has a prime "Week 1" upset potential. Especially at this number. This line has moved a point since opening at Buffalo -7. 

Best Bet: Cardinals +6 (-110) with DraftKings Sportsbook

Tennessee Titans at Chicago Bears, 1 p.m. (Fox)

Buzz: The Bears jettisoned Justin Fields and made No. 1 overall pick Caleb Williams their QB of the future. While Williams has the makings of a top-tier NFL QB, this is the sort of game in which the Bears and their fans will miss Fields. The Titans defense gets first crack at the first pick in the draft. Hope those fans in Chicago are patient. 

Best Bet: Titans +4.5 (-110) with DraftKings Sportsbook

New England Patriots at Cincinnati Bengals, 1 p.m. (CBS)

Buzz: The Patriots are on to Cincinnati in their first regular-season game not coached by Bill Belichick in 25 years. Jerod Mayo enters the NFL as a head coach. Jacoby Brissett will likely be his starting QB. The Patriots defense might keep things competitive for three quarters, but New England may well challenge its 12.9 PPG total from last season. New England is one of two teams - Carolina being the other - which is an underdog in all 17 games. Joe Burrow makes his first start since suffering a wrist injury in Week 11 last season. The Bengals are ready to roar. The Patriots are marking time until Drake Maye can assume the QB 1 spot. This is a big Week 1 number. Keep an eye on it for it to improve in the Bengals' favor. It's already moved a half-point since the open.

Best Bet: Bengals -9 (-110) with DraftKings Sportsbook

Houston Texans at Indianapolis Colts, 1 p.m. (CBS)

Buzz: Anthony Richardson returns as the Colts starting QB after an injury-shortened rookie season. He's still a largely unknown. Houston QB C.J. Stroud emerged during the second-half of last season to be the NFL's latest QB sensation. The Texans got a taste of the playoffs and have a shot in the wide-open AFC South. The Colts, not so much. 

Best Bet: Texans ML (-140) with DraftKings Sportsbook

Jacksonville Jaguars at Miami Dolphins, 1 p.m. (CBS)

Buzz: The "Battle of Florida - Trevor's Version" takes place in the heart of hurricane season at Hard Rock Stadium. The Jaguars collapsed in closing third of the season. After an 8-3 start, in which they held the No. 1 seed in the AFC, Jacksonville lost its final five games. And missed the postseason. Miami should be fully thawed from its playoff loss at Kansas City. And they added OBJ this offseason to bolster an already stellar receiving corps. Fun Fact Of The Week: Trevor Lawrence beat Tua Tagovailoa in the national championship game five years ago. No this time. 

Best Bet: Dolphins -3 (-110) with DraftKings Sportsbook

Carolina Panthers at New Orleans Saints, 1 p.m. (Fox)

Buzz: The Panthers are one of two teams - the Patriots being the other - who are underdogs in all 17 games this regular season. The Saints have won 5 straight season openers. The pushed and covered against Carolina last season. But they've otherwise struggled within the division. The Saints need to fix that if they hope to within the Falcons and Bucs at the end of the season. It starts here. At home. 

Best Bet: Saints -4 (-110) with DraftKings Sportsbook

Minnesota Vikings at New York Giants, 1 p.m. (Fox)

Buzz: The Giants have tried as hard as any NFL team in recent memory to shake their starting QB. But barring injury, Daniel Jones takes the first snap in his final season with Big Blue. The Vikings, meanwhile, have closed the Kirk Cousins Era and expected to go with rookie J.J. McCarthy as their QB of the present and he was lost in the preseason until 2025. The Vikings have penciled in Sam Darnold as their starting QB. This game is a contender for the fewest point total of the week. 

Best Bet: Under 41.5 Points (-110) with DraftKings Sportsbook

Las Vegas Raiders at Los Angeles Chargers, 4:05 p.m. (CBS)

Buzz: Welcome (back) to the NFL, Jim Harbaugh. The first-year Chargers coach will be in for a shock when SoFi Stadium is packed with Raiders fans, many of whom long for the day that team played in LA. Harbaugh's offense will be fun to watch and he's the most proficient offensive-minded coach Justin Herbert's had in his NFL career. Keep an eye on Herbert in the NFL's futures markets, BTW. The Raiders QB room is considered the worst in the NFL. This game could get out of hand early. 

Best Bet: Chargers -3.5 (-110) with DraftKings Sportsbook

Denver Broncos at Seattle Seahawks, 4:05 p.m. (CBS)

Buzz: For the first time since 2009, someone other than Pete Carroll will be coaching the Seahawks. But Geno Smith returns at QB. And that should be enough in Week 1. Former Oregon QB Bo Nix will make his NFL debut in the Great Northwest for the Broncos. It won't matter much in the case of the Broncos, whose offense is headed for anemia at best. 

Best Bet: Under 42 Points (-110) with DraftKings Sportsbook

Washington Commanders at Tampa Bay Buccaneers, 4:25 p.m. (Fox)

Buzz: The Buccaneers brought back much of the band this offseason. The Buccaneers have won the NFC South three straight seasons (Tom Brady had to settle for the wild card in his first year with the Bucs). Baker Mayfield had his best season as a starter last year and appears to have found a home and stability in Tampa Bay. Mike Evans got his bag and returns, as does Antoine Winfield. The Commanders will debut Heisman Trophy winner and rookies QB Jaylen Daniels (the No. 2 overall pick) against the Bucs defense. He might not recover. Yikes. 

Best Bet: Buccaneers -3.5 (-110) with DraftKings Sportsbook

Dallas Cowboys at Cleveland Browns, 4:25 p.m. (Fox)

Buzz: We could go on about the “The Clash Of What Might Have Been QB Titans” featuring Dak Prescott and Deshaun Watson. But the only quarterback who matters in this game – at least to the millions watching on TV – is Tom Brady. This game marks the debut of Brady as the lead in-game analyst for Fox. The GOAT has a 10-year deal with the network that pays him $37.5 million per year. Both the Cowboys and Browns made the playoffs last season, only to be crushed in the first round. But Watson and Prescott will be healthy for this match-up, which should be a fun one to watch. The Browns defense often rose to the moment last season. We liked the Browns ML when this game opened as a pick at -115, but it's move too far since to -140.

Best Bet: Over 43 Points (-110) with DraftKings Sportsbook

Los Angeles Rams at Detroit Lions, 8:20 p.m. (NBC)

Buzz: Jared Goff hit Powerball this offseason as he and the Lions agreed to a 4-year $212 million contract extension, with $170 million guaranteed. Say what you will about Goff, but it wasn't his fault the Lions didn't kick that field goal against San Francisco in the NFC championship game. This game is a sneaky good playoff rematch from last season. The Lions have the best record on the line of any NFL team over the past three seasons at 37-17 ATS. That's whopping 68.5%. No reason to stop now. This number has moved a half-point since it opened at Lions -3.

Best Bet: Lions -3.5 (-110) with DraftKings Sportsbook

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Monday, September 9

New York Jets at San Francisco 49ers, 8:20 p.m. (ESPN)

Buzz: Aaron Rodgers makes just his second start since leaving the Green Bay Packers after the 2022 season. He took four snaps for the Jets in 2023 before his ACL snapped and he was lost for the season. Rodgers should be fully reacquainted with his offense by Week 1. The 49ers are coming off an overtime Super Bowl loss. That takes a toll. The 49ers went 6-10 the season after losing Super Bowl 54. Expect the Jets defense to keep Brock Purdy off the pocket. Rodgers has 6 wins in his 9 starts against the 49ers, while throwing for 2.597 yards, 20 TDs and just 2 picks. This line has made the biggest move of Week 1, as Jets money has shaved 1.5 points off the number. We'll stick with Aaron Rodgers on his "home" turf of Northern California.

Best Bet: Jets +4 (-105) with DraftKings Sportsbook